T1? MRI AS A QUANTITATIVE BIOMARKER OF DISC DEGENERATION IN VIVO

T1？

• 批准号: 8361988
• 负责人: ARI BORTHAKUR
• 金额: $ 2.31万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361988
• 关键词: Aging; Biochemical; Biological Markers; Blood Vessels; Collagen Fiber; Diffusion; Disease; Disease Progression; Failure; Funding; Gel; Goals; Gold; Grant; Height; Individual; Intervertebral disc structure; Low Back Pain; Magnetic Resonance; Magnetic Resonance Imaging; Measurement; Measures; National Center for Research Resources; Needles; Nutrient; Pain; Patient Care; Patients; Perception; Principal Investigator; Proteoglycan; Research; Research Infrastructure; Resources; Source; Staging; Techniques; Tissues; United States National Institutes of Health; Waste Products; Water; Width; age related; cost; improved; in vivo; intervertebral disk degeneration; nucleus pulposus; optical imaging

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Healthy intervertebral discs rely on diffusion to transport nutrients and waste products between the surrounding blood vessels and the ordered collagen fibers of the annulus fibrosus (AF), to the central gel-like nucleus pulposus (NP). Age related degradation is marked by a loss of the gel-like consistency of the NP including decreased proteoglycan (PG) content and decreased water concentration. Degenerated intervertebral discs are marked by structural failure and accelerated aging, and when painful, are considered to have degenerate disc disease (DDD). The later stages of DDD are characterized by an NP indistinguishable from AF and a collapsed disc space. DDD is a common cause of lower back pain (LBP). Due to the lack of a proper gold standard, the presence of pain in each disc is currently determined by provocative discography. The technique relies on the patients' subjective perception of pain as a needle is inserted into the disc. We believe a more reliable, objective, and non-invasive determinant of pain in degenerate discs will improve patient care. Towards this goal, we evaluated the predictability of disc pain in LBP patients by fusing T1¿ with disc height ratio (DHR) measurements. The DHR, the average disc height normalized by the width of the disc, can be measured from conventional MRI, and provides a measure of disease progression. While disc height (to width) ratio is a measure of disc quality, it may also be a potential predictor of individual disc pain. The non-invasive technique of T1¿ MRI may be advantageous in objectively detecting DDD at an earlier stage than the DHR, since it is sensitive to biochemical changes in the tissue that precede disc height changes.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 健康的椎间盘依靠扩散来运输营养物质和废物 在周围血管和纤维环的有序胶原纤维之间 纤维核（AF）至中央凝胶样髓核（NP）。年龄相关的退化是 以NP的凝胶样稠度丧失为特征，包括蛋白聚糖减少 (PG)含量和水浓度降低。退变的椎间盘是 以结构破坏和加速老化为特征，当疼痛时，被认为是 椎间盘退行性疾病（DDD）DDD的后期阶段的特征是 NP无法与AF和椎间隙塌陷区分。DDD是一种常见的 下背痛（LBP）由于缺乏适当的金本位制， 在每一个光盘是目前确定的挑衅discography。该技术依赖 对患者的主观疼痛感的影响。我们 我相信一个更可靠，客观，非侵入性的决定疼痛的退化 光盘将改善病人护理。 为了实现这一目标，我们通过融合腰椎间盘突出症患者的椎间盘疼痛， T1 <$和椎间盘高度比（DHR）测量值。DHR，平均椎间盘高度 通过椎间盘的宽度标准化，可以从常规MRI测量， 提供了疾病进展的量度。当圆盘高度（与宽度）比为 作为椎间盘质量的指标，它也可能是个体椎间盘疼痛的潜在预测因素。 T1 <$MRI的无创技术在客观上可能是有利的， 在比DHR更早的阶段检测DDD，因为它对生物化学敏感 椎间盘高度变化之前的组织变化。