T1? MRI OF PATIENTS WITH PARKINSON?S DISEASE WITH AND WITHOUT DEMENTIA

T1？

• 批准号: 8361980
• 负责人: ARI BORTHAKUR
• 金额: $ 0.77万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361980
• 关键词: Affect; Age; Brain; Clinical; Dementia; Development; Disease; Funding; Grant; Hippocampus (Brain); Magnetic Resonance; Magnetic Resonance Imaging; Measures; National Center for Research Resources; Neurodegenerative Disorders; Parkinson Disease; Patients; Principal Investigator; Research; Research Infrastructure; Resources; Source; Substantia nigra structure; Time; United States National Institutes of Health; cohort; cost; disorder risk; dopaminergic neuron; optical imaging; outcome forecast; treatment strategy

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Parkinson's disease (PD) is a neurodegenerative disorder that affects an estimated 1 million people in the US and tens of millions worldwide and is associated with the loss of dopaminergic neurons in the substantia nigra. Dementia is common and affects approximately 40% of PD patients during the course of the disease, the risk for the development of dementia in PD being 6 times higher than in non-PD age-matched controls. Operationalized criteria to define the clinical boundaries between PD and PD with dementia (PDD) are also lacking, although this distinction may have profound clinical implications for prognosis and treatment strategies. In this study we measure T1¿ in hippocampus in the brain of PD, and PDD patients and age matched control, and to determine whether T1¿ values can be used in differentiating these cohorts.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 帕金森氏病（PD）是一种神经退行性疾病，在美国约有100万人受到影响。 美国和全世界数千万人，并与多巴胺能神经元的损失有关， 黑质痴呆是常见的，并且在治疗期间影响大约40%的PD患者。 在病程中，PD患者发生痴呆的风险是PD患者的6倍， 非PD年龄匹配对照。定义PD之间临床界限的可操作标准 和PD痴呆（PDD）也缺乏，尽管这种区别可能具有深刻的临床意义。 对预后和治疗策略的影响。 在这项研究中，我们测量了PD患者和年龄匹配的PDD患者大脑海马中的T1 <$。 对照，并确定T1？值是否可用于区分这些队列。