T1? MRI AS A QUANTITATIVE BIOMARKER OF DISC DEGENERATION IN VIVO

T1？

• 批准号: 8169082
• 负责人: ARI BORTHAKUR
• 金额: $ 1.73万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169082
• 关键词: Biochemical; Biological Markers; Biomedical Research; Cell Nucleus; Computer Retrieval of Information on Scientific Projects Database; Development; Disease; Disease Progression; Funding; Future; Gold; Grant; Health; Height; Institution; Intervertebral disc structure; Liquid substance; Magnetic Resonance Imaging; Measures; Methods; Osmotic Pressure; Pain; Patients; Perception; Proteoglycan; Recruitment Activity; Research; Research Personnel; Resources; Selection for Treatments; Source; Staging; Techniques; Technology; Tissues; United States National Institutes of Health; Vertebral column; Width; in vivo; intervertebral disk degeneration; normal aging; pressure

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Degenerative disc disease (DDD) of the intervertebral disc (IVD) in its early stage is caused in part by the loss of proteoglycan in the nucleus pulpous (NP) of the IVD. Degenerate discs eventually have decreased height but are confounded with changes that occur in disc height as a result of normal aging. The Pfirrmann grade determined from T2 MRI is currently the gold standard to determine disc degeneration. This method, however, relies on subjective observer-scored morphologic features of the disc. A quantitative assessment of disc health is essential for selection of treatment options and to the future of biomedical research in the development of new spine technologies. A potential quantitative indicator of degeneration is the opening pressure (OP), defined as the pressure where injected fluid first overcomes the internal osmotic pressure and enters the disc. However, this method is invasive and relies on the patient's perception of pain. The disc height ratio (DHR), the average disc height normalized by the width of the disc, can be measured from conventional MRI, and provides a measure of disease progression. The non-invasive technique of T1¿ MRI may be advantageous in objectively detecting DDD at an earlier stage than the DHR, since it is sensitive to biochemical changes in the tissue that precede disc height changes. The objective of this study is to evaluate T1¿ MRI as quantitative biomarker of disc degeneration in patients being treated for LBP. These patients, and others still being recruited to the study, will be followed over the next several years to determine the change in NP T1¿ of adjacent non-operative levels and thus evaluate for potential progression of disc degeneration

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 椎间盘（IVD）的退行性椎间盘疾病（DDD）在其早期阶段部分由以下原因引起： IVD的髓核（NP）中蛋白多糖的损失。退化的椎间盘最终 高度降低，但与正常椎间盘高度变化混淆 衰老根据T2 MRI确定的Pfirrmann分级目前是确定椎间盘突出的金标准。 退化然而，这种方法依赖于患者的主观评分形态学特征。 disc.椎间盘健康的定量评估对于治疗方案的选择和患者的康复至关重要。 生物医学研究的未来在新的脊柱技术的发展。潜在的定量 退化的指标是打开压力（OP），其被定义为注入的流体在打开时的压力。 首先克服内部渗透压并进入椎间盘。然而，这种方法是侵入性的。 并依赖于病人对疼痛的感知。椎间盘高度比（DHR），平均椎间盘高度 通过椎间盘的宽度标准化，可以从常规MRI测量，并提供了一个 衡量疾病进展。T1 <$MRI的非侵入性技术可能有利于 在比DHR更早的阶段客观地检测DDD，因为它对生物化学敏感 椎间盘高度变化之前的组织变化。本研究的目的是评估 T1 <$MRI作为接受LBP治疗的患者椎间盘退变的定量生物标志物。这些 在接下来的几年里， 确定相邻非手术节段的NP T1 <$的变化，从而评估 椎间盘退变的潜在进展