T1? MRI OF PATIENTS WITH ALZHEIMER?S DISEASE

T1？

• 批准号: 8361953
• 负责人: ARI BORTHAKUR
• 金额: $ 3.08万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361953
• 关键词: Age; Alzheimer' s Disease; Biological; Brain; Brain Neoplasms; Cartilage; Chemicals; Development; Diagnosis; Discrimination; Disease; Early Diagnosis; Environment; Funding; Grant; Image; Magnetic Resonance; Magnetic Resonance Imaging; Measurement; Methods; Monitor; National Center for Research Resources; Patients; Principal Investigator; Process; Proteins; Protons; Relaxation; Research; Research Infrastructure; Resources; Role; Source; Techniques; Time; Tissues; United States National Institutes of Health; base; cohort; cost; interest; malignant breast neoplasm; nervous system disorder; novel; optical imaging; outcome forecast

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. There is significant interest in the development of novel non-invasive techniques for the early diagnosis of Alzheimer disease (AD). The increasing demand for a noninvasive measurement has driven the development of imaging based methods. Magnetic resonance imaging (MRI) is non-invasive and routinely performed in the setting of neurological disease, implementation of new MRI-based techniques for the diagnosis and prognosis of AD is especially advantageous. An alternate MR contrast mechanism is T1¿, the spin lattice relaxation time constant in the rotating frame, which generates a different type of contrast than that seen with conventional relaxation times (T1 and T2). T1¿ relaxation phenomena in biological tissues have been extensively studied and shown to be sensitive to physio-chemical processes (e.g. spin-spin interaction, chemical exchange). In proteins and biological tissues, exchange between protons in different environments contributes to T1¿ relaxation. T1¿ MRI has been widely used to characterize breast cancer tissue, monitor the level of cartilage degeneration and delineate brain tumors. The current study deal with the measurement of T1¿ in the brain of AD, MCI and age matched control, and determine the role of T1¿ in discrimination of these three cohorts.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 人们对开发用于早期诊断的新型非侵入性技术非常感兴趣 阿尔茨海默病（AD）。对无创测量日益增长的需求推动了 开发基于成像的方法。磁共振成像 (MRI) 是一种非侵入性且 在神经系统疾病的情况下常规进行，实施新的基于 MRI 的 技术对于AD的诊断和预后尤其有利。备用 MR 对比机制是T1¿，旋转框架中的自旋晶格弛豫时间常数，其中 产生与传统弛豫时间（T1 和 T2）不同类型的对比度。 生物组织中的 T1 弛豫现象已被广泛研究并证明 对物理化学过程敏感（例如自旋相互作用、化学交换）。在蛋白质中 和生物组织，不同环境中质子之间的交换有助于 T1¿ 松弛。 T1¿ MRI已广泛用于表征乳腺癌组织、监测水平 软骨退化和描绘脑肿瘤。 目前的研究涉及 AD、MCI 和年龄匹配对照大脑中 T1¿ 的测量， 并确定 T1¿ 在区分这三个群体中的作用。