T1? MRI OF PATIENTS WITH ALZHEIMER?S DISEASE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 有显着的兴趣在发展新的非侵入性技术的早期诊断 阿尔茨海默病（AD）。对非侵入性测量的日益增长的需求推动了 发展基于成像的方法。磁共振成像（MRI）是非侵入性的， 在神经系统疾病的情况下常规进行，实施新的基于MRI的 用于AD的诊断和预后的技术尤其有利。替代MR 对比机制是T1 <$，旋转坐标系中的自旋晶格弛豫时间常数， 产生与常规弛豫时间（T1和T2）不同类型的对比度。 生物组织中的T1？弛豫现象已被广泛研究，并表明 对物理化学过程敏感（例如自旋-自旋相互作用、化学交换）。蛋白质中 和生物组织，质子在不同环境中的交换有助于T1？ 放松. T1 <$MRI已被广泛用于表征乳腺癌组织，监测水平 软骨退化和脑肿瘤的特征 目前的研究涉及AD、MCI和年龄匹配对照的脑中T1 <$的测量， 并确定T1 <$在区分这三个队列中的作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There is significant interest in the development of novel non-invasive techniques for the early diagnosis of Alzheimer disease (AD). The increasing demand for a noninvasive measurement has driven the development of imaging based methods. Magnetic resonance imaging (MRI) is non-invasive and routinely performed in the setting of neurological disease, implementation of new MRI-based techniques for the diagnosis and prognosis of AD is especially advantageous. An alternate MR contrast mechanism is T1¿, the spin lattice relaxation time constant in the rotating frame, which generates a different type of contrast than that seen with conventional relaxation times (T1 and T2). T1¿ relaxation phenomena in biological tissues have been extensively studied and shown to be sensitive to physio-chemical processes (e.g. spin-spin interaction, chemical exchange). In proteins and biological tissues, exchange between protons in different environments contributes to T1¿ relaxation. T1¿ MRI has been widely used to characterize breast cancer tissue, monitor the level of cartilage degeneration and delineate brain tumors. The current study deal with the measurement of T1¿ in the brain of AD, MCI and age matched control, and determine the role of T1¿ in discrimination of these three cohorts.