CHARACTERIZATION OF BLOOD FLOW IN DENTAL PULP

牙髓中血流的表征

• 批准号: 8362688
• 负责人: PETRA E WILDER-SMITH
• 金额: $ 0.31万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362688
• 关键词: Biotechnology; Blood flow; Data; Dental; Dental Pulp; Diagnosis; Funding; Grant; Health; Image; In Vitro; Lasers; Measurement; Monitor; National Center for Research Resources; Periodontal Diseases; Principal Investigator; Research; Research Infrastructure; Resources; Source; Techniques; Tooth structure; United States National Institutes of Health; cost; in vivo; instrument; prototype; pulpal blood flow; treatment planning; treatment response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Periodontal disease: Characterization of dental pulp, with Petra Wilder-Smith, UC-Irvine The ability to monitor pulpal vitality is crucial for accurate diagnosis and optimal treatment planning. Currently, there exists no accurate means of clinically assessing pulpal health and treatment response. The aim of this study is to develop and validate a non-invasive technique for non-invasively determining pulpal blood flow. In vitro studies have shown that laser speckle imaging using a 633 nm HeNe laser can detect blood flow values within the pulpal chambers of teeth. The ability to detect and semi-quantify different flow rates in the dental pulp has been clearly demonstrated. The data show that with higher flow rates, high speckle flow values are given. We currently are performing in vivo measurements with a prototype dental LSI instrument

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 牙周病：牙髓的表征，与Petra Wilder-Smith，UC-Irvine 监测牙髓活力的能力对于准确诊断和最佳治疗计划至关重要。目前，临床上还没有准确的方法来评估牙髓健康和治疗反应。本研究的目的是开发和验证一种非侵入性的技术，用于非侵入性地确定牙髓血流量。体外研究表明，使用633 nm HeNe激光的激光散斑成像可以检测牙齿牙髓室内的血流值。已经清楚地证明了检测和半定量牙髓中不同流速的能力。数据显示，随着更高的流速，给出了高的散斑流值。我们目前正在进行体内测量与原型牙科LSI仪器