REVERSAL OF MUCOSITIS BY GMSC-BASED THERAPY
基于 GMSC 的疗法逆转粘膜炎
基本信息
- 批准号:8169526
- 负责人:
- 金额:$ 0.21万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-04-01 至 2011-03-31
- 项目状态:已结题
- 来源:
- 关键词:Adverse effectsBody WeightBone Marrow TransplantationCaliforniaCell TherapyCellsClinicalColitisComputer Retrieval of Information on Scientific Projects DatabaseCoupledDisease modelDoseExhibitsFundingGastrointestinal tract structureGingivaGrantHeadHomingImmuneIn VitroInflammationInflammatoryInflammatory InfiltrateInjuryInstitutionInterleukin-17LaboratoriesMediator of activation proteinMicroscopyMolecular BiologyMucositisMusOptical Coherence TomographyPatientsRadiationRecruitment ActivityRegulatory T-LymphocyteResearchResearch PersonnelResourcesSchool DentistrySeveritiesSiteSourceStem cellsT-LymphocyteTechnologyTestingTissuesUnited States National Institutes of HealthUniversitiesbasecancer therapychemotherapycraniofacialcytokinehuman stem cellsin vivoself-renewalstem cell population
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California
Mucositis of the alimentary tract (AT) is a debilitating side effect of cancer therapies in a high percentage of patients receiving chemotherapy, bone marrow transplantation, and high-dose radiation to the head and neck.Recent studies from our laboratory have isolated a new population of stem cells from human gingiva, an easily accessible tissue source, namely GMSC, which exhibit not only multipotent differentiation and self-renewal capacities, but also possess distinct immunomodulatory functions. Cell-based therapy with GMSC significantly ameliorated both clinical and histopathological severities of the colonic inflammation in the experimental murine colitis, presumably by suppressing inflammatory infiltrates, specifically interleukin-17 (IL-17) secreting cells, and a myriad of inflammatory cytokines/mediators, and recruiting regulatory T cells (Tregs) at the colonic sites. In another disease model of mucosal inflammation induced by chemotherapy, we observed a significant reversal of AT mucositis and regain of body weight in nearly 100% of mice undergoing an exploratory one dose treatment with GMSC
Experimental Approaches: We will examine the immunomodulatory effects of GMSC on Treg and Th17 functions and how they contribute to mucositis using both in vitro and in vivo studies. Optical coherence tomography (OCT) coupled with multiphoton microscopy (MMP) technology will be utilized to decipher stem cell homing to mucositic sites. We will test whether adaptive transfer with Pan-T cells, ex vivo expanded Tregs, and pharmacologic immune boosting therapies can reverse mucosal injuries.
这个子项目是许多研究子项目中的一个
由NIH/NCRR资助的中心赠款提供的资源。子项目和
研究者(PI)可能从另一个NIH来源获得了主要资金,
因此可以在其他CRISP条目中表示。所列机构为
研究中心,而研究中心不一定是研究者所在的机构。
美国南加州大学牙科学院颅面分子生物学中心
消化道粘膜炎(AT)是癌症治疗的一种使人衰弱的副作用,在接受化疗、骨髓移植和头颈部高剂量放疗的患者中,AT的比例很高。我们实验室最近的研究从人类牙龈中分离出一种新的干细胞群,即GMSC,它不仅表现出多能分化和自我更新能力,还具有明显的免疫调节功能。基于细胞的GMSC治疗显著改善了实验性小鼠结肠炎中结肠炎症的临床和组织病理学严重程度,推测是通过抑制炎性浸润,特别是白介素-17(IL-17)分泌细胞和无数炎性细胞因子/介质,并在结肠部位募集调节性T细胞(TCFs)。在另一种由化疗诱导的粘膜炎症的疾病模型中,我们观察到AT粘膜炎的显著逆转和体重的恢复,几乎100%的小鼠经历了GMSC的探索性单剂量治疗
实验方法:我们将研究GMSC对Treg和Th 17功能的免疫调节作用,以及它们如何通过体外和体内研究促进粘膜炎。光学相干断层扫描(OCT)与多光子显微镜(MMP)技术相结合,将用于破译干细胞归巢粘膜网站。我们将测试是否适应性转移与泛T细胞,离体扩增的T细胞,和药理学免疫增强疗法可以逆转粘膜损伤。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
PETRA E WILDER-SMITH其他文献
PETRA E WILDER-SMITH的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('PETRA E WILDER-SMITH', 18)}}的其他基金
Mobile oral cancer screening system for low-resource settings
适用于资源匮乏环境的移动口腔癌筛查系统
- 批准号:
10323692 - 财政年份:2021
- 资助金额:
$ 0.21万 - 项目类别:
A Low-Cost Simple Oral Cancer Screening Device for Low-Resource Settings
适用于资源匮乏环境的低成本简单口腔癌筛查设备
- 批准号:
8267452 - 财政年份:2012
- 资助金额:
$ 0.21万 - 项目类别:
A Low-Cost Simple Oral Cancer Screening Device for Low-Resource Settings
适用于资源匮乏环境的低成本简单口腔癌筛查设备
- 批准号:
8475596 - 财政年份:2012
- 资助金额:
$ 0.21万 - 项目类别:
FLUORESCENCE BASED DETECTION AND DIAGNOSIS OF MALIGNANCY
基于荧光的恶性肿瘤检测和诊断
- 批准号:
6378039 - 财政年份:2000
- 资助金额:
$ 0.21万 - 项目类别:
FLUORESCENCE BASED DETECTION AND DIAGNOSIS OF MALIGNANCY
基于荧光的恶性肿瘤检测和诊断
- 批准号:
6188984 - 财政年份:2000
- 资助金额:
$ 0.21万 - 项目类别:
相似海外基金
Effects of probiotics on the postoperative body weight and skeletal muscle mass according to the operative methods for gastric cancer
益生菌对胃癌手术方式术后体重和骨骼肌质量的影响
- 批准号:
23K08118 - 财政年份:2023
- 资助金额:
$ 0.21万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Linking insufficient sleep with body weight in Black emerging adults.
将睡眠不足与黑人新生成年人的体重联系起来。
- 批准号:
10665139 - 财政年份:2023
- 资助金额:
$ 0.21万 - 项目类别:
The Role of IRX3 Neurons in the Regulation of Body Weight Homeostasis
IRX3 神经元在体重稳态调节中的作用
- 批准号:
10752469 - 财政年份:2023
- 资助金额:
$ 0.21万 - 项目类别:
Role of Central Neurotensin Signaling in the Ventral Tegmental Area for Ingestive Behavior and Body Weight
中枢神经降压素信号在腹侧被盖区对摄入行为和体重的作用
- 批准号:
10536558 - 财政年份:2022
- 资助金额:
$ 0.21万 - 项目类别:
Role of Central Neurotensin Signaling in the Ventral Tegmental Area for Ingestive Behavior and Body Weight
中枢神经降压素信号在腹侧被盖区对摄入行为和体重的作用
- 批准号:
10665597 - 财政年份:2022
- 资助金额:
$ 0.21万 - 项目类别:
Brainstem GABA neurons orchestrate feeding and body weight
脑干 GABA 神经元协调进食和体重
- 批准号:
BB/V016849/1 - 财政年份:2022
- 资助金额:
$ 0.21万 - 项目类别:
Research Grant
Effects of Time-restricted Eating versus Daily Continuous Calorie Restriction on Body Weight and Colorectal Cancer Risk Markers among Adults with Obesity
限时饮食与每日持续热量限制对肥胖成人体重和结直肠癌风险标志物的影响
- 批准号:
10304332 - 财政年份:2021
- 资助金额:
$ 0.21万 - 项目类别:
The role of regulator of G protein signaling Gbeta5-R7 in neuronal control of body weight
G蛋白信号调节剂Gbeta5-R7在神经元控制体重中的作用
- 批准号:
10539336 - 财政年份:2021
- 资助金额:
$ 0.21万 - 项目类别:
Time restricted feeding versus daily calorie restriction: Effect on body weight, metabolic risk, and the gut microbiome
时间限制喂养与每日热量限制:对体重、代谢风险和肠道微生物组的影响
- 批准号:
10488263 - 财政年份:2021
- 资助金额:
$ 0.21万 - 项目类别: