A Low-Cost Simple Oral Cancer Screening Device for Low-Resource Settings

描述（由申请人提供）：我们的长期目标是开发一种廉价，简单，便携式的口腔癌筛查方法，由低资源环境中的基层卫生保健工作者在现场进行。筛查将确定一个人是否需要前往具有更高水平口腔癌专业知识的中心进行进一步检查和潜在的癌症治疗。本申请的目的是重新设计现有技术，以提供一种基于光学相干断层扫描（OCT）和简单诊断算法的廉价、非常小、坚固的便携式口腔癌诊断系统，该诊断系统指示每个个体的进一步诊断和治疗需求。简而言之，根据第一个具体目标，将在欧文市的加州大学建造一个基于光学相干断层扫描（OCT）的强大便携式口腔癌诊断系统，并进行临床测试。根据具体 目标2，微型OCT设备和简单的诊断算法将在印度的一家专业头颈癌诊所进行测试，并由该领域的低级别医护人员进行测试。加州尔湾大学和班加罗尔Mazumdar-Shaw癌症中心的研究人员之间拟议的合作工作直接响应PAR 11-044，因为拟议的设备将由基层医疗保健工作者提供即时癌症筛查。低成本，便携式，强大的成像系统将有潜力集成到一个联网的移动的诊断网络。本案无关全球每年发生275，000例口腔癌（OC）和125，000例因OC而死亡，OC占印度癌症病例的50%。由于超过2/3的OC病变被发现较晚，治疗结果和预后极差。目前还没有便携式，低成本，强大的，廉价的简单手段，在现场的口腔癌筛查的基层卫生保健工作者。我们建议开发和验证一种诊断方法，克服这一关键障碍，在低资源环境中广泛筛查高危人群。这种低成本、便携式的终端产品将为未来的网络化和移动的技术提供基础，以便通过现场受过最低限度教育的医护人员进行远程癌症诊断。 公共卫生相关性：全世界每年发生275，000例口腔癌（OC）和125，000例因OC而死亡，2/3的OC病变在治疗效果极差时被发现。没有便携式、低成本、简单的口腔癌筛查方法。我们建议开发和验证一种诊断模式，用于在低资源环境中广泛筛查高风险人群，这将为未来网络化和移动的技术提供基础，通过该领域受过最低教育的医护人员进行远程癌症诊断。

DESCRIPTION (provided by applicant): Our long-term goal is to develop an inexpensive, simple, portable means of screening for oral cancer in the field by basic level healthcare workers in low-resource environments. Screening will identify whether a person needs to travel to a center with higher levels of expertise in oral cancer for further tests and potential cancer therapy. The objective of this application is to re- engineer existing technology to provide an inexpensive very small, robust portable diagnostic system for oral cancer based on Optical Coherence Tomography (OCT) and a simple diagnostic algorithm that indicates further diagnostic and treatment needs for each individual. Briefly, under the first Specific Aim a robust portable diagnostic system for oral cancer based on Optical Coherence Tomography (OCT) will be constructed and undergo clinical testing at the university of California, Irvine. Under Specific Aim 2, the mini-OCT device and a simple diagnostic algorithm will be tested in India in a specialty Head and Neck Cancer Clinic, and by low-level healthcare workers in the field. The proposed collaborative work between researchers at the University of California Irvine and the Mazumdar-Shaw Cancer Center in Bangalore is directly responsive to PAR 11-044 as the proposed device will provide point-of-care cancer screening by basic level healthcare workers. The low-cost, portable, robust imaging system will have the potential for integration into a networked mobile diagnostic network. Relevance. Annually 275,000 oral cancers (OC) and 125,000 deaths due to OC occur worldwide, and OC accounts for up to 50% of cancer cases in India. Because over 2/3 of OC lesions are detected late, treatment outcomes and prognoses are extremely poor. Currently there exists no portable, low-cost, robust, inexpensive simple means of screening for oral cancer in the field by basic-level healthcare workers. We propose to develop and validate a diagnostic modality that will overcome this critical barrier to widespread screening of high-risk populations in low-resource environments. The low-cost, portable end product will provide the basis for future networked and mobile technology for remote cancer diagnostics via minimally educated healthcare workers in the field. PUBLIC HEALTH RELEVANCE: Annually 275,000 oral cancers (OC) and 125,000 deaths due to OC occur worldwide, and 2/3 of OC lesions are detected late when treatment prognoses are extremely poor. There exists no portable, low-cost, simple means of screening for oral cancer. We propose to develop and validate a diagnostic modality for widespread screening of high-risk populations in low-resource environments that will provide the basis for future networked and mobile technology for remote cancer diagnostics via minimally educated healthcare workers in the field.