A Low-Cost Simple Oral Cancer Screening Device for Low-Resource Settings

适用于资源匮乏环境的低成本简单口腔癌筛查设备

基本信息

批准号：
8475596
负责人：
PETRA E WILDER-SMITH
金额：
$ 10.89万
依托单位：
UNIVERSITY OF CALIFORNIA-IRVINE
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-06-01 至 2016-09-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8475596
关键词：
Accounting Affect African Age Algorithms Area Biomedical Engineering Biopsy California Cancer Center Cancer Diagnostics Caring Cessation of life Clinic Complex Consultations Data Devices Diagnosis Diagnostic Diagnostic Neoplasm Staging Disease Early Diagnosis Engineering Environment Feedback Female Future Goals Head and Neck Cancer Health Personnel Image Incidence India Individual Institutes Ionizing radiation Lasers Lesion Light Localized Disease Malignant Neoplasms Medical Modality Operative Surgical Procedures Optical Coherence Tomography Optics Oral Diagnosis Oral cavity Patients Persons Population Principal Investigator Process Research Personnel Resources Screening for Oral Cancer Screening for cancer Staging Survival Rate System Technology Testing Time Tissues Travel Treatment outcome Universities Visual Work base cancer therapy cost design experience high risk in vivo innovation malignant mouth neoplasm medical specialties oral premalignancy outcome forecast outreach point of care programs research clinical testing screening tool trend

项目摘要

DESCRIPTION (provided by applicant): Our long-term goal is to develop an inexpensive, simple, portable means of screening for oral cancer in the field by basic level healthcare workers in low-resource environments. Screening will identify whether a person needs to travel to a center with higher levels of expertise in oral cancer for further tests and potential cancer therapy. The objective of this application is to re- engineer existing technology to provide an inexpensive very small, robust portable diagnostic system for oral cancer based on Optical Coherence Tomography (OCT) and a simple diagnostic algorithm that indicates further diagnostic and treatment needs for each individual. Briefly, under the first Specific Aim a robust portable diagnostic system for oral cancer based on Optical Coherence Tomography (OCT) will be constructed and undergo clinical testing at the university of California, Irvine. Under Specific Aim 2, the mini-OCT device and a simple diagnostic algorithm will be tested in India in a specialty Head and Neck Cancer Clinic, and by low-level healthcare workers in the field. The proposed collaborative work between researchers at the University of California Irvine and the Mazumdar-Shaw Cancer Center in Bangalore is directly responsive to PAR 11-044 as the proposed device will provide point-of-care cancer screening by basic level healthcare workers. The low-cost, portable, robust imaging system will have the potential for integration into a networked mobile diagnostic network. Relevance. Annually 275,000 oral cancers (OC) and 125,000 deaths due to OC occur worldwide, and OC accounts for up to 50% of cancer cases in India. Because over 2/3 of OC lesions are detected late, treatment outcomes and prognoses are extremely poor. Currently there exists no portable, low-cost, robust, inexpensive simple means of screening for oral cancer in the field by basic-level healthcare workers. We propose to develop and validate a diagnostic modality that will overcome this critical barrier to widespread screening of high-risk populations in low-resource environments. The low-cost, portable end product will provide the basis for future networked and mobile technology for remote cancer diagnostics via minimally educated healthcare workers in the field.

描述（由申请人提供）：我们的长期目标是开发一种廉价，简单，便携式的，可通过低资源环境中的基本级别的医护人员在现场筛查该野外口腔癌的方法。筛查将确定一个人是否需要前往具有更高水平的口腔癌专业知识的中心，以进行进一步的测试和潜在的癌症治疗。该应用的目的是根据现有的技术来基于光学相干断层扫描（OCT）和一种简单的诊断算法，为口腔癌提供非常廉价的便携式诊断系统，以表明每个人的进一步诊断和治疗需求。简而言之，在第一个特定的目标下，将在加利福尼亚大学尔湾分校建造基于光学相干断层扫描（OCT）（OCT）基于光学相干断层扫描（OCT）的稳健便携式诊断系统。在具体下 AIM 2，Mini-OCT设备和简单的诊断算法将在印度的专业头和颈部癌诊所以及该领域的低级医疗保健工人进行测试。加利福尼亚大学尔湾分校的研究人员与班加罗尔的Mazumdar-shaw癌症中心之间的拟议合作工作直接响应PAR 11-044，因为拟议的设备将通过基本水平的医疗保健工人提供治疗癌症的筛查。低成本，便携式，健壮的成像系统将有可能集成到网络移动诊断网络中。关联。全球每年275,000个口服癌症（OC）和125,000人死亡，OC在印度占癌症病例的50％。由于较晚检测到超过2/3的OC病变，因此治疗结果和预后非常差。目前，没有基本级别的医疗保健工人在野外筛查该野外口腔癌的便携式，低成本，廉价的简单方法。我们建议开发和验证一种诊断方式，以克服在低资源环境中广泛筛查高风险人群的关键障碍。低成本，便携式最终产品将通过该领域的最低限制的医疗保健工人为将来的网络和移动技术提供基础。