A Low-Cost Simple Oral Cancer Screening Device for Low-Resource Settings

描述(申请人提供)：我们的长期目标是开发一种廉价、简单、便携的方法，供基层医务人员在低资源环境中现场筛查口腔癌。筛查将确定一个人是否需要前往口腔癌专业水平较高的中心进行进一步测试和潜在的癌症治疗。该应用程序的目标是对现有技术进行重新设计，以提供一种基于光学相干断层扫描(OCT)的廉价、非常小巧、功能强大的便携式口腔癌诊断系统和一种简单的诊断算法，该算法可指示每个个体的进一步诊断和治疗需求。简而言之，在第一个特定目标下，将构建一个基于光学相干断层扫描(OCT)的强大的便携式口腔癌诊断系统，并在加州大学欧文分校进行临床测试。在特定项下 AIM 2，迷你OCT设备和简单的诊断算法将在印度的一家头颈部癌症专科诊所进行测试，并由现场的低水平医护人员进行测试。加州大学欧文分校的研究人员和班加罗尔的Mazumdar-Shaw癌症中心之间拟议的合作工作直接响应了PAR 11-044，因为拟议的设备将提供由基层医护人员进行的点式癌症筛查。这种低成本、便携、坚固的成像系统将有可能集成到联网的移动诊断网络中。关联性。全球每年发生275,000例口腔癌和125,000例口腔癌死亡，在印度，口腔癌占癌症病例的50%。由于超过2/3的OC病变发现较晚，治疗结果和预后极差。目前，基层医护人员尚无便携、低成本、健壮、廉价的口腔癌现场筛查简单手段。我们建议开发和验证一种诊断模式，该模式将克服在低资源环境中广泛筛查高危人群的这一关键障碍。这种低成本的便携式终端产品将为未来的网络和移动技术提供基础，通过受过最低程度教育的现场医护人员进行远程癌症诊断。

DESCRIPTION (provided by applicant): Our long-term goal is to develop an inexpensive, simple, portable means of screening for oral cancer in the field by basic level healthcare workers in low-resource environments. Screening will identify whether a person needs to travel to a center with higher levels of expertise in oral cancer for further tests and potential cancer therapy. The objective of this application is to re- engineer existing technology to provide an inexpensive very small, robust portable diagnostic system for oral cancer based on Optical Coherence Tomography (OCT) and a simple diagnostic algorithm that indicates further diagnostic and treatment needs for each individual. Briefly, under the first Specific Aim a robust portable diagnostic system for oral cancer based on Optical Coherence Tomography (OCT) will be constructed and undergo clinical testing at the university of California, Irvine. Under Specific Aim 2, the mini-OCT device and a simple diagnostic algorithm will be tested in India in a specialty Head and Neck Cancer Clinic, and by low-level healthcare workers in the field. The proposed collaborative work between researchers at the University of California Irvine and the Mazumdar-Shaw Cancer Center in Bangalore is directly responsive to PAR 11-044 as the proposed device will provide point-of-care cancer screening by basic level healthcare workers. The low-cost, portable, robust imaging system will have the potential for integration into a networked mobile diagnostic network. Relevance. Annually 275,000 oral cancers (OC) and 125,000 deaths due to OC occur worldwide, and OC accounts for up to 50% of cancer cases in India. Because over 2/3 of OC lesions are detected late, treatment outcomes and prognoses are extremely poor. Currently there exists no portable, low-cost, robust, inexpensive simple means of screening for oral cancer in the field by basic-level healthcare workers. We propose to develop and validate a diagnostic modality that will overcome this critical barrier to widespread screening of high-risk populations in low-resource environments. The low-cost, portable end product will provide the basis for future networked and mobile technology for remote cancer diagnostics via minimally educated healthcare workers in the field.