DNA DAMAGE RECOGNITION AND REPAIR DURING CELL DIVISION

细胞分裂过程中 DNA 损伤的识别和修复

• 批准号: 8362645
• 负责人: Michael W. Berns
• 金额: $ 0.51万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362645
• 关键词: Affect; Biotechnology; Cell division; Cells; Chromosome Segregation; DNA Damage; DNA Double Strand Break; Funding; Generations; Grant; Lasers; Mitosis; National Center for Research Resources; Principal Investigator; Research; Research Infrastructure; Resources; Source; United States National Institutes of Health; Work; cost; daughter cell; repaired; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The aim is to characterize the cellular response to DNA double strand break damage during mitosis in mamalian cells. The scope of this work will include affects on spindle checkpoint, proper segregation of chromosomes and generation of daughter cells.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 目的是研究哺乳动物细胞在有丝分裂过程中对DNA双链断裂损伤的反应。这项工作的范围将包括对纺锤体检查点的影响，适当的染色体分离和子代细胞的产生。