MACCHESS PROGRAM FOR NEW STATION FOR LONG WAVELENGTH CRYSTALLOGRAPHY

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 Crane小组(康奈尔大学)将光化学和X射线结晶学相结合，研究生物钟蛋白质和负责产生这种蛋白质的酶机制 活性氮的种类。这两个系统都具有重要的生理作用和生物医学意义，都涉及含血红素蛋白的结构-功能研究[134]。在铁吸收边缘收集的结晶学数据无疑将提供关于这些蛋白质如何在生物信息传输中发挥作用的更多知识。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The Crane group (Cornell) combines photochemistry and X-ray crystallography to study circadian clock proteins and the enzymatic machinery responsible for the generation of reactive nitrogen species. Both of these systems, which have important physiological roles and biomedical implications, involve structure-function studies of heme-containing proteins [134]. Crystallographic data collected at the iron absorption edge will undoubtedly provide enhanced knowledge of how these proteins function in biological information transfer.