STRUCTURE OF FLAGELLA COMPLEX

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 在趋化过程中，细菌的运动由鞭毛的旋转方向决定。鞭毛的旋转方向由位于细胞膜中的转子控制，这些转子由超过25种不同的蛋白质组成。蛋白质FliM、FliN和FliG形成鞭毛组装的组成部分，并且它们中的每一个的多个拷贝形成转子的C环。目前的努力是为了了解这些蛋白质之间的相互作用，并预测其复合物的结构。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. During chemotaxis, the motion of the bacteria is determined by the sense of rotation of the flagella. The direction of rotation of flagella is controlled by rotors located in the cell membrane which are composed of more than 25 different proteins. Proteins FliM, FliN and FliG form integral part of flagella assembly and multiple copies of each of them form the C-ring of the rotor. Current efforts are directed to understand the interactions between these proteins and predict the structure of their complex.