IMPROVING AUTOMATION AND KINETICS CAPABILITIES AT BIOCAT

提高 BIOCAT 的自动化和动力学能力

• 批准号: 8361285
• 负责人: Tobin R Sosnick
• 金额: $ 0.59万
• 依托单位: ILLINOIS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361285
• 关键词: Automation; Biophysics; Equilibrium; Funding; Grant; Kinetics; Measurement; National Center for Research Resources; Principal Investigator; Pump; Research; Research Infrastructure; Resources; Source; Syringes; Testing; United States National Institutes of Health; beamline; cost; data acquisition; improved; protein folding

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Automation is essential for increasing the thoughput of the BioCAT SAXS beamline. We proposed to implement automated SAXS measurements in both equilibrium and kinetic modes at BioCAT. Test applications were on protein folding. We integrated the control of syringe pumps with shutters and data acquisition.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其他NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 自动化对于增加BioCAT SAXS光束线的吞吐量至关重要。 我们建议在BioCAT实现平衡和动力学模式下的自动SAXS测量。 测试应用程序是在蛋白质折叠。 我们将注射泵的控制与快门和数据采集集成在一起。