GLYCAN EXPRESSION ON CARBOHYDRATE ASSOCIATED EPITOPE CA215

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 糖链相关表位(S)(CA215)主要存在于多种组织来源的癌细胞表达的Ig SF蛋白中。癌细胞中可以检测到CA215，既有分泌型的，也有膜结合型的。监测血清CA215在癌症患者中被用作泛癌生物标志物。为了确定这个碳水化合物表位的一级结构，我们研究了糖链的表达和蛋白质上的糖基化位点。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Carbohydrate associated epitope(s) (CA215) is mainly present in the IgSF proteins expressed by cancer cells of many human tissue origins. CA215 could be detected in cancer cells, both in secreted and membrane-bound forms. Monitoring of serum CA215 was used in cancer patients as the pan cancer biomarker. To identify the primary structure of this carbohydrate epitope, we characterized glycan expression and site of glycosylation on the protein.