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INTERNAL FUSION PEPTIDE OF THE SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS

INTERNAL FUSION PEPTIDE OF THE SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS
严重急性呼吸系统综合症冠状病毒的内部融合肽
批准号:
8364059
负责人:
MAOCHEN GE
金额:
$0.08万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2011
资助国家:
美国
项目状态:
已结题
起止时间:
2011-09-01 至 2012-08-31

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中文摘要
翻译
这个子项目是利用这些资源的众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We have initiated a study of lipid interactions of a synthetic peptide corresponding to the internal fusion peptide from SARS-CoV (IFP18). Fusion peptide can be classified as an N-terminal or internal, depending on their location relative to the cleavage site of the viral fusion protein. The coronavirus spike protein (S) protein is known to be cleaved at the S1/S2 boundary. This cleavage site is not closely linked to a fusion peptide. It was reported that a synthetic peptide, consisting of 18 resides, immediately C-terminal to a second S2 cleavage site of SARS-CoV (IFP18), promotes lipid mixing. Mutagenesis studies showed that some conserved residues in this sequence of SARS-CoV are critical in viral fusion mediated by SARS-Cov. Thus, this peptide was suggested to be an internal fusion peptide [1]. [1] Madu, I.G., S.L. Roth, S. Belouzard, and G.R. Whittaker. 2009. Characterization of highly conserved domains within the severe acute respiratory syndrome coronavirus spike protein S2 domain with characteristics of a viral fusion peptide. J. Virol. 83:7411-7421.
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FUSION PORE DYNAMICS IN INFLUENZA HEMAGGLUTININ-MEDIATED MEMBRANE FUSION
  • 批准号:
    8364088
  • 项目类别:
  • 资助金额:
    $0.16万
  • 财政年份:
    2011
  • 负责人:
    MAOCHEN GE
  • 依托单位:
STRUCTURAL AND DYNAMIC STUDIES OF MEMBRANE DOMAINS IN MAST CELLS
  • 批准号:
    8364067
  • 项目类别:
  • 资助金额:
    $0.37万
  • 财政年份:
    2011
  • 负责人:
    MAOCHEN GE
  • 依托单位:
ESR STUDIES OF PHASE STRUCTURES IN DSPC/POPC/CHOL AND DSPC/DOPC/CHOL MIXTURES
  • 批准号:
    8364041
  • 项目类别:
  • 资助金额:
    $0.05万
  • 财政年份:
    2011
  • 负责人:
    MAOCHEN GE
  • 依托单位:
ESR STUDIES OF DYNAMIC STRUCTURES OF PLASMA MEMBRANE VESICLES FROM SF9 CELLS
  • 批准号:
    8364042
  • 项目类别:
  • 资助金额:
    $0.05万
  • 财政年份:
    2011
  • 负责人:
    MAOCHEN GE
  • 依托单位:
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