RC5 STRESS-INDUCED DRINKING IN EMERGING ADULTS: THE ROLE OF TRAUMA HISTORY

在生活中的任何时候暴露于创伤事件的个体，特别是那些发展为创伤后应激障碍（PTSD）的人，有更高的酗酒问题发生率。然而，很少有人知道创伤，创伤后应激障碍和饮酒之间的关系，在“新兴的成年人”（年龄21 - 30岁），尽管这个年龄组是在最高的风险，发展随后的饮酒问题。拟定的临床实验室项目将采用三组设计。目标人群将无创伤暴露[对照组]、无创伤暴露而无PTSD [TE组]和创伤暴露伴PTSD [PTSD组]。的 包括的创伤事件暴露史类型将限于人际创伤。本项目将使用一个完善的临床实验室范式的压力诱导在当前的中心资助期间，特里尔社会压力测试（TSST），调查的作用，暴露于创伤的历史上的反应TSST和压力诱导的自愿饮酒。受试者将不符合酒精依赖的诊断标准。每组中的一半将接受TSST，另一半将随机分配至无强制降解条件。使用主观的以及生物指标的压力，第一个具体的目的是检查创伤史的压力反应性的影响，使用主观的，神经内分泌和生理措施的压力。第二个具体目标将使用临床实验室范例中的既定程序来检查创伤史对随后的饮酒行为和对酒精的主观反应的影响。此外，亦将进行探索性分析，以探讨创伤史组与主观应激反应，以及创伤史组与饮酒之间的相关性。两个额外的探索性分析将评估痛苦耐受性的人格特质（高和低）的影响，以及携带5-HTTLPR多态性的"S"或罕见的"L {G}"等位基因对应激反应和应激诱导后自愿饮酒的影响。 这项研究将促进我们对人际创伤史、压力和饮酒之间关系的理解。这一系列研究的最终目标是在不健康的饮酒习惯和/或依赖发展之前，在饮酒生涯的早期确定"高危"群体。这些信息有可能为预防和干预酒精研究提供信息。

Individuals exposed to a traumatic event at any time in their life, particularly those who develop posttraumatic stress disorder (PTSD), have a higher incidence of problematic drinking. However, little is known about the relationship between trauma, PTSD, and drinking in "emerging adults" (ages 21-30 years), in spite of this age group being at highest risk of developing subsequent drinking problems. The proposed clinical laboratory project will use a three group design. The target population will have no trauma exposure [Control group], trauma exposure without PTSD [TE group], and trauma exposure with PTSD [PTSD group]. The type of traumatic event exposure history included will be limited to interpersonal trauma. This project will use a well-established clinical laboratory paradigm of stress induction employed during the current Center funding period, the Trier Social Stress Test (TSST), to investigate the role of a history of exposure to trauma on reactivity to the TSST and on stress-induced voluntary drinking. Subjects will not meet diagnostic criteria for alcohol dependence. Half of each group will receive the TSST and the other half will be randomized to the no stress condition. Using subjective as well as biological indices of stress, the first specific aim examines the effect of trauma history on stress reactivity, using subjective, neuroendocrine, and physiological measures of stress. The second specific aim will examine the effect of trauma history on subsequent drinking behavior and subjective response to alcohol using established procedures in a clinical laboratory paradigm. Exploratory analyses will also be conducted to examine the correlation between trauma history group and subjective response to stress, and trauma history group and drinking. Two additional exploratory analyses will evaluate the effect of the personality trait of distress tolerance (high and low), and the effect of carrying the 'S' or the rare 'L{G}' allele of the 5-HTTLPR polymorphism on the stress response and on voluntary drinking following stress induction. This study will advance our understanding of the relationship between a history of interpersonal trauma, stress, and drinking. The ultimate goal of this line of research is to identify "at risk" groups early in their drinking careers, before unhealthy drinking practices and/or dependence develop. This information has the potential to inform prevention and intervention alcohol research.