Mentorship and Research in HIV and Addiction Prevention Among Traumatized Youth

 描述(由申请人提供)：这份K24提案的目的是成倍地加强Carla Kmett Danielson博士在创新方法方面的指导和研究计划，以降低青少年中艾滋病毒感染和成瘾的风险，特别是关注创伤暴露人群。丹尼尔森博士是一位临床心理学家和科学家，他是这一机制的理想人选。自2005年以来，她的以患者为导向的研究(POR)一直得到联邦政府的持续资助，这为她指导19名初级调查人员提供了框架，这些调查人员对药物滥用与高危性行为和创伤的共病科学做出了贡献。她的指导对象包括早期职业教师、博士后研究员和博士后心理学实习生，他们通过高影响力的出版物和NIH资助的独立研究项目，在艾滋病毒预防、药物滥用和创伤应激领域做出了重大贡献。Danielson博士在POR指导方面的长期奉献和成就进一步得到了证明，她在NIH资助的T32项目中担任PI，该项目致力于创伤应激及其终生后遗症的临床研究培训，并担任MUSC精神病学和行为科学系教师指导计划的联合主席(目前在NIH资助的国家中排名第7)。拟议的K24奖项将是至关重要的，为候选人提供必要的时间和资源，以正规化、扩展和维持她的指导计划和能力，进一步刺激她的受训者的研究计划(例如，通过建议的实习生试点奖励计划和新的培训机会)，并增强她的研究技能，以及为面临艾滋病毒感染和成瘾风险的创伤青少年提供电子和移动健康技术研究的不断增长的计划。Danielson博士在K24下提出的创新研究涉及开发和评估一种动态的、以技术为基础的预防工具--工具包(电子艾滋病毒-性教育和创伤青少年成瘾风险；eHEARTT)。该工具包将提高接受创伤治疗的青少年艾滋病毒风险和药物使用预防干预的质量、可及性和有效性。这项研究的具体目的是：1)开发eHEARTT工具包，以支持在提供以创伤为重点的治疗期间提供循证艾滋病毒和药物使用预防干预措施(TF-CBT)；2)与青少年、护理者和临床医生一起对eHEARTT工具包进行可用性测试，以指导改进；以及3)对40个家庭进行随机对照可行性试验，通过为期6个月的治疗后跟踪评估，评估TF-CBT+eHEARTT与TF-CBT+eHEARTT的比较。这些目标与丹尼尔森博士提出的导师活动和目前联邦政府资助的在艾滋病毒预防、减少物质使用风险和青少年创伤领域的研究项目很好地协调。拟议的研究为她的导师(早期职业教师、博士后研究员和博士后心理学实习生，重点是来自临床科学中代表性不足的群体的实习生)提供了丰富的培训机会，并将为面临艾滋病毒感染和成瘾风险的青少年的POR提供新的方向。拟议的工作与NIDA的优先事项和资金公告直接一致，这些优先事项和资金公告呼吁进行研究，以评估新技术的应用，以提供针对毒品和酒精使用和预防艾滋病毒感染的适当预防干预措施。

 DESCRIPTION (provided by applicant): The purpose of this K24 proposal is to enhance exponentially Dr. Carla Kmett Danielson's mentorship and research program in innovative approaches to risk reduction of HIV infection and addiction among adolescents, with a particular focus on trauma-exposed populations. Dr. Danielson, a clinical psychologist and scientist, is the ideal candidate for this mechanism. She has sustained continuous federal-funding of her patient oriented research (POR) since 2005, which has provided the framework for her mentorship of 19 junior investigators contributing to the science of substance abuse comorbidity with high-risk sexual behaviors and trauma. Her mentees, who have included early career faculty, postdoctoral fellows, and predoctoral psychology interns, have made significant contributions to the HIV prevention, substance abuse, and traumatic stress fields through high-impact publications and independent lines of NIH-funded research. Dr. Danielson's long-standing dedication and achievements in POR mentorship are further evidenced through her leadership roles as PI of an NIH-funded T32 Program dedicated to clinical research training in traumatic stress and its sequelae across the lifespan and as Co-Chair for the Faculty Mentorship Program in MUSC's Department of Psychiatry and Behavioral Sciences (currently ranked 7th in the country for NIH funding). The proposed K24 award will be essential in providing time and resources necessary for the candidate to formalize, expand, and sustain her mentoring program and capacity, further stimulate the research program of her mentees (e.g., through a proposed trainee pilot award program and new training opportunities) and augment her research skills and growing program of research in e- and m-health technologies for traumatized adolescents at risk for HIV infection and addiction. Innovative research proposed by Dr. Danielson under the K24 involves development and evaluation of a dynamic, technology-based prevention tool-kit (electronic HIV-sex Education and Addiction Risk for Traumatized Teens; eHEARTT). The toolkit will enhance the quality, accessibility, and efficacy of HIV- risk and substance use prevention interventions for adolescents receiving trauma-focused treatment. Specific aims of the research are to: 1) Develop the eHEARTT toolkit to support delivery of evidence-based HIV and substance use prevention interventions during the delivery of trauma-focused treatment (TF-CBT); 2) Conduct usability tests of the eHEARTT toolkit with teens, caregivers, and clinicians to guide refinements; and 3) Conduct a randomized controlled feasibility trial with 40 families to evaluate TF-CBT plus eHEARTT in comparison to TF-CBT plus a risk behavior electronic Resource List through a 6-month post-treatment follow- up assessment. These aims harmonize well with Dr. Danielson's proposed mentorship activities and current federally-funded research projects in the areas of HIV prevention, substance use risk reduction, and trauma among teens. The proposed research affords rich training opportunities for her mentees (early career faculty, postdoctoral fellows, and predoctoral psychology interns with an emphasis on trainees from groups under- represented in clinical science) and will invigorate new directions in POR with teens at risk for HIV infection and addiction. The proposed work is directly in line with NIDA priorities and funding announcements that call for research designed to evaluate the application of new technologies for delivering adapted prevention interventions targeting drug and alcohol use and prevention of HIV acquisition.