Mentorship and Research in HIV and Addiction Prevention Among Traumatized Youth

 描述（由申请人提供）：本K24提案的目的是以指数方式增强Carla Kmett Danielson博士在创新方法方面的指导和研究计划，以降低青少年感染艾滋病毒和成瘾的风险，特别关注创伤暴露人群。临床心理学家和科学家丹尼尔森博士是这种机制的理想人选。自2005年以来，她一直持续获得联邦政府对她的患者导向研究（POR）的资助，这为她指导19名初级研究人员提供了框架，这些研究人员为药物滥用与高风险性行为和创伤的科学研究做出了贡献。她的学员，包括早期职业教师，博士后研究员和博士前心理学实习生，通过高影响力的出版物和独立的NIH资助的研究，为艾滋病毒预防，药物滥用和创伤应激领域做出了重大贡献。丹尼尔森的长期奉献精神和成就POR导师进一步证明了她的领导作用作为美国国立卫生研究院资助的T32计划的PI致力于创伤应激及其后遗症的临床研究培训在整个生命周期，并作为共同主席的教师导师计划在MUSC的精神病学和行为科学系（目前在美国国立卫生研究院资助的国家排名第七）。拟议的K24奖将为候选人提供必要的时间和资源，以正式化，扩大和维持她的指导计划和能力，进一步刺激她的学员的研究计划（例如，通过拟议的实习生试点奖励计划和新的培训机会），并提高她的研究技能和不断增长的电子和移动卫生技术的研究计划，为有艾滋病毒感染和成瘾风险的创伤青少年。Danielson博士在K24下提出的创新研究涉及开发和评估一个动态的、基于技术的预防工具包（电子艾滋病毒性教育和创伤青少年成瘾风险; eHEARTT）。该工具包将提高针对接受创伤治疗的青少年的艾滋病毒风险和药物使用预防干预措施的质量、可及性和效力。该研究的具体目标是：1）开发eHEARTT工具包，以支持在提供以创伤为中心的治疗（TF-CBT）期间提供基于证据的艾滋病毒和药物使用预防干预措施; 2）与青少年，护理人员和临床医生一起进行eHEARTT工具包的可用性测试，以指导改进;和3）通过6个月的治疗后随访评估，对40个家庭进行随机对照可行性试验，以评价TF-CBT + eHEARTT与TF-CBT+风险行为电子资源列表的比较。这些目标与丹尼尔森博士提出的指导活动和目前联邦政府资助的艾滋病毒预防、减少药物使用风险和青少年创伤等领域的研究项目协调一致。拟议的研究为她的学员提供了丰富的培训机会（早期职业教师，博士后研究员和博士前心理学实习生，重点是来自临床科学中代表性不足的群体的学员），并将为青少年感染艾滋病毒和成瘾的青少年提供新的方向。拟议的工作直接符合NIDA的优先事项和资金公告，要求进行旨在评估新技术应用的研究，以提供针对药物和酒精使用以及预防艾滋病毒感染的适应性预防干预措施。

 DESCRIPTION (provided by applicant): The purpose of this K24 proposal is to enhance exponentially Dr. Carla Kmett Danielson's mentorship and research program in innovative approaches to risk reduction of HIV infection and addiction among adolescents, with a particular focus on trauma-exposed populations. Dr. Danielson, a clinical psychologist and scientist, is the ideal candidate for this mechanism. She has sustained continuous federal-funding of her patient oriented research (POR) since 2005, which has provided the framework for her mentorship of 19 junior investigators contributing to the science of substance abuse comorbidity with high-risk sexual behaviors and trauma. Her mentees, who have included early career faculty, postdoctoral fellows, and predoctoral psychology interns, have made significant contributions to the HIV prevention, substance abuse, and traumatic stress fields through high-impact publications and independent lines of NIH-funded research. Dr. Danielson's long-standing dedication and achievements in POR mentorship are further evidenced through her leadership roles as PI of an NIH-funded T32 Program dedicated to clinical research training in traumatic stress and its sequelae across the lifespan and as Co-Chair for the Faculty Mentorship Program in MUSC's Department of Psychiatry and Behavioral Sciences (currently ranked 7th in the country for NIH funding). The proposed K24 award will be essential in providing time and resources necessary for the candidate to formalize, expand, and sustain her mentoring program and capacity, further stimulate the research program of her mentees (e.g., through a proposed trainee pilot award program and new training opportunities) and augment her research skills and growing program of research in e- and m-health technologies for traumatized adolescents at risk for HIV infection and addiction. Innovative research proposed by Dr. Danielson under the K24 involves development and evaluation of a dynamic, technology-based prevention tool-kit (electronic HIV-sex Education and Addiction Risk for Traumatized Teens; eHEARTT). The toolkit will enhance the quality, accessibility, and efficacy of HIV- risk and substance use prevention interventions for adolescents receiving trauma-focused treatment. Specific aims of the research are to: 1) Develop the eHEARTT toolkit to support delivery of evidence-based HIV and substance use prevention interventions during the delivery of trauma-focused treatment (TF-CBT); 2) Conduct usability tests of the eHEARTT toolkit with teens, caregivers, and clinicians to guide refinements; and 3) Conduct a randomized controlled feasibility trial with 40 families to evaluate TF-CBT plus eHEARTT in comparison to TF-CBT plus a risk behavior electronic Resource List through a 6-month post-treatment follow- up assessment. These aims harmonize well with Dr. Danielson's proposed mentorship activities and current federally-funded research projects in the areas of HIV prevention, substance use risk reduction, and trauma among teens. The proposed research affords rich training opportunities for her mentees (early career faculty, postdoctoral fellows, and predoctoral psychology interns with an emphasis on trainees from groups under- represented in clinical science) and will invigorate new directions in POR with teens at risk for HIV infection and addiction. The proposed work is directly in line with NIDA priorities and funding announcements that call for research designed to evaluate the application of new technologies for delivering adapted prevention interventions targeting drug and alcohol use and prevention of HIV acquisition.