Mentorship and Research in HIV and Addiction Prevention Among Traumatized Youth

对受创伤青少年进行艾滋病毒和成瘾预防的指导和研究

• 批准号: 8923700
• 负责人: CARLA KMETT DANIELSON
• 金额: $ 16.21万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8923700
• 关键词: AIDS prevention; Achievement; Address; Adolescent; Aftercare; Alcohol or Other Drugs use; Area; Award; Behavioral Sciences; Caregivers; Caring; Child Abuse and Neglect; Childhood; Clinical; Clinical Research; Clinical Sciences; Comorbidity; Country; Data; Dedications; Development; Drug usage; Education; Educational Curriculum; Electronics; Evaluation; Evidence based treatment; Exposure to; Faculty; Family; Feasibility Studies; Feeling; Funding; Glean; Goals; HIV; HIV Infections; HIV risk; Health; Health Technology; Human immunodeficiency virus test; Individual; Institutional National Research Service Award; Interview; Leadership; Learning; Life Experience; Longevity; Mental Depression; Mentors; Mentorship; Methods; Mid-Career Clinical Scientist Award (K24); Modeling; National Institute of Drug Abuse; Oral cavity; Outcome; Population; Post-Traumatic Stress Disorders; Postdoctoral Fellow; Preparation; Prevention; Preventive Intervention; Procedures; Process; Protocols documentation; Psychiatry; Psychologist; Psychology; Public Health; Publications; Randomized; Reaction; Reporting; Research; Research Design; Research Personnel; Research Project Grants; Research Training; Resources; Risk; Risk Behaviors; Risk Factors; Risk Reduction; Role; Science; Scientist; Sex Education; Sexual abuse; Signal Transduction; Specific qualifier value; Stress; Substance Use Disorder; Substance abuse problem; Surveys; Swab; Tablets; Technology; Teenagers; Test Result; Testing; Time; Training; Trauma; United States National Institutes of Health; Update; Violence; Vulnerable Populations; Work; Youth; addiction; base; career; checkup examination; condoms; cost; design; deter alcohol use; early onset substance use; effective intervention; evidence base; experience; follow-up; handheld mobile device; high risk; high risk behavior; high risk sexual behavior; innovation; interest; lifetime risk; mHealth; new technology; patient oriented; patient oriented research; physical abuse; pre-doctoral; programs; public health priorities; public health relevance; sex risk; sexual trauma; skills; stem; substance use prevention; tool; traumatic event; usability; web-accessible

 DESCRIPTION (provided by applicant): The purpose of this K24 proposal is to enhance exponentially Dr. Carla Kmett Danielson's mentorship and research program in innovative approaches to risk reduction of HIV infection and addiction among adolescents, with a particular focus on trauma-exposed populations. Dr. Danielson, a clinical psychologist and scientist, is the ideal candidate for this mechanism. She has sustained continuous federal-funding of her patient oriented research (POR) since 2005, which has provided the framework for her mentorship of 19 junior investigators contributing to the science of substance abuse comorbidity with high-risk sexual behaviors and trauma. Her mentees, who have included early career faculty, postdoctoral fellows, and predoctoral psychology interns, have made significant contributions to the HIV prevention, substance abuse, and traumatic stress fields through high-impact publications and independent lines of NIH-funded research. Dr. Danielson's long-standing dedication and achievements in POR mentorship are further evidenced through her leadership roles as PI of an NIH-funded T32 Program dedicated to clinical research training in traumatic stress and its sequelae across the lifespan and as Co-Chair for the Faculty Mentorship Program in MUSC's Department of Psychiatry and Behavioral Sciences (currently ranked 7th in the country for NIH funding). The proposed K24 award will be essential in providing time and resources necessary for the candidate to formalize, expand, and sustain her mentoring program and capacity, further stimulate the research program of her mentees (e.g., through a proposed trainee pilot award program and new training opportunities) and augment her research skills and growing program of research in e- and m-health technologies for traumatized adolescents at risk for HIV infection and addiction. Innovative research proposed by Dr. Danielson under the K24 involves development and evaluation of a dynamic, technology-based prevention tool-kit (electronic HIV-sex Education and Addiction Risk for Traumatized Teens; eHEARTT). The toolkit will enhance the quality, accessibility, and efficacy of HIV- risk and substance use prevention interventions for adolescents receiving trauma-focused treatment. Specific aims of the research are to: 1) Develop the eHEARTT toolkit to support delivery of evidence-based HIV and substance use prevention interventions during the delivery of trauma-focused treatment (TF-CBT); 2) Conduct usability tests of the eHEARTT toolkit with teens, caregivers, and clinicians to guide refinements; and 3) Conduct a randomized controlled feasibility trial with 40 families to evaluate TF-CBT plus eHEARTT in comparison to TF-CBT plus a risk behavior electronic Resource List through a 6-month post-treatment follow- up assessment. These aims harmonize well with Dr. Danielson's proposed mentorship activities and current federally-funded research projects in the areas of HIV prevention, substance use risk reduction, and trauma among teens. The proposed research affords rich training opportunities for her mentees (early career faculty, postdoctoral fellows, and predoctoral psychology interns with an emphasis on trainees from groups under- represented in clinical science) and will invigorate new directions in POR with teens at risk for HIV infection and addiction. The proposed work is directly in line with NIDA priorities and funding announcements that call for research designed to evaluate the application of new technologies for delivering adapted prevention interventions targeting drug and alcohol use and prevention of HIV acquisition.

 描述（由申请人提供）：本 K24 提案的目的是大幅加强 Carla Kmett Danielson 博士在减少青少年 HIV 感染和成瘾风险的创新方法方面的指导和研究计划，特别关注遭受创伤的人群。临床心理学家和科学家丹尼尔森博士是这种机制的理想人选。自 2005 年以来，她一直持续为她的以患者为导向的研究 (POR) 提供联邦资助，该研究为她指导 19 名初级研究人员提供了框架，这些研究人员致力于药物滥用与高风险性行为和创伤共存疾病的科学研究。她的学员包括早期职业教师、博士后研究员和博士前心理学实习生，他们通过高影响力的出版物和 NIH 资助的独立研究领域，为艾滋病毒预防、药物滥用和创伤性应激领域做出了重大贡献。 Danielson 博士在 POR 指导方面的长期奉献和成就通过她作为 NIH 资助的 T32 项目的 PI 的领导角色得到了进一步证明，该项目致力于创伤性应激及其终生后遗症的临床研究培训，以及作为 MUSC 精神病学和行为科学系教师指导项目的联合主席（目前在 NIH 资助中排名全国第七）。拟议的 K24 奖项对于为候选人提供必要的时间和资源至关重要，以正式确定、扩大和维持她的指导计划和能力，进一步刺激其学员的研究计划（例如，通过拟议的实习生试点奖励计划和新的培训机会），并增强她的研究技能和不断发展针对面临艾滋病毒感染和成瘾风险的受创伤青少年的电子和移动医疗技术研究计划。 Danielson 博士在 K24 下提出的创新研究涉及开发和评估动态的、基于技术的预防工具包（针对创伤青少年的电子艾滋病毒性教育和成瘾风险；eHEARTT）。该工具包将提高针对接受创伤治疗的青少年的艾滋病毒风险和药物使用预防干预措施的质量、可及性和有效性。该研究的具体目标是： 1) 开发 eHEARTT 工具包，以支持在以创伤为中心的治疗 (TF-CBT) 期间提供基于证据的艾滋病毒和药物使用预防干预措施； 2) 与青少年、护理人员和临床医生一起进行 eHEARTT 工具包的可用性测试，以指导改进； 3) 对 40 个家庭进行随机对照可行性试验，通过 6 个月的治疗后随访评估来评估 TF-CBT 加 eHEARTT 与 TF-CBT 加风险行为电子资源列表的比较。这些目标与丹尼尔森博士提议的指导活动以及当前联邦政府资助的艾滋病毒预防、减少药物使用风险和青少年创伤等领域的研究项目非常吻合。拟议的研究为她的学员（早期职业教师、博士后研究员和博士前心理学实习生，重点是来自临床科学领域代表性不足的群体的学员）提供了丰富的培训机会，并将为处于艾滋病毒感染和成瘾风险的青少年的 POR 领域注入新的方向。拟议的工作直接符合 NIDA 的优先事项和资助公告，这些优先事项和资助公告呼吁开展旨在评估新技术应用的研究，以提供针对吸毒和酗酒以及预防艾滋病毒感染的适应性预防干预措施。