RESOURCE CORE 2: APPLIED PHYSIOLOGY AND TISSUE MECHANISMS

RC-2 心血管失调，慢性炎症和内分泌代谢功能障碍是固有的， 老年人身体损伤的病理生理学， 衰老肌肉减少症、体能差、炎症、代谢综合征和残疾相关急性事件， 例如中风和髋部骨折，随着年龄增长而发生，并可能使活动性恶化， 心血管疾病（CVD）和代谢异常。RC-2的中心假设是， 包括有氧和阻力训练在内的康复可以改善多个生理系统， 老年人、行动受限的个体，导致功能表现改善，心脏代谢风险降低， 预防功能衰退。该核心侧重于以下具体目标： 1)提供学习支持，指导和培训OAIC学者，初级教师和OAIC研究人员， 与运动相关的应用运动生理学和组织机制研究 恢复患有慢性致残性疾病的老年人的功能并预防其功能下降; 2)促进进行肌肉骨骼和组织机械运动康复和预防 UM-OAIC试点项目中的老龄化和残疾医学研究，RCDC学者的研究和 外部NIH和VA资助的研究。 我们已经结合了两个核心，从我们以前的胡椒中心到一个更全面的核心，在这个 在整个身体和组织水平上整合实验室和临床研究的应用。RC-2领导层 研究人员代表了一个由基础科学家和临床老年病学家组成的多学科团队， 一起工作了15年这个核心与其他核心和研究工作协同工作 团体，以促进我们的基本理解的机制，行使康复 恢复功能，降低代谢风险，防止残疾人的功能下降，以及 运动康复增强身体机能和组织代谢的机制。

RC-2 Cardiovascular deconditioning, chronic inflammation, and endocrine-metabolic dysfunction are inherent to the pathophysiology of the physical impairments in older persons hindered by disabling chronic diseases of aging. Sarcopenia, poor fitness, inflammation, metabolic syndrome, and acute events related to disability, such as stroke and hip fracture, occur with advancing age and may worsen mobility and increase risk for cardiovascular disease (CVD) and metabolic abnormalities. The central hypothesis of RC-2 is that exercisefocused rehabilitation including aerobic and resistive training can improve multiple physiological systems in older, mobility limited individuals leading to improved functional performance, reduced cardiometabolic risk, and prevention of functional decline. This core focuses on the following specific aims: 1) To provide study support, mentor and train OAIC scholars, junior faculty and OAIC researchers in the performance of applied exercise physiology and tissue mechanisms research relevant to exercise-based restoration of function and prevention of functional declines in older people with chronic disabling diseases; 2) To facilitate the conduct of musculoskeletal and tissue mechanistic exercise rehabilitation and preventive medical research in aging and disability across the UM-OAIC pilot projects, RCDC Scholars' research and external NIH and VA funded research. We have combined two cores from our prior Pepper Centers into one more comprehensive core in this application that integrates bench and clinical research at the whole body and tissue level. RC-2 leadership and investigators represent a multidisciplinary team of basic scientists with clinical geriatricians who have worked together for 15 years. This core works synergistically with the other cores and research working groups to contribute to our fundamental understanding of the mechanisms by which exercise rehabilitation restores function, reduces metabolic risk and prevents functional decline in disabled individuals, as well as the mechanisms by which exercise rehabilitation enhances physical function and tissue metabolism.