RESOURCE CORE 3: MOBILITY FUNCTION AND NEUROMOTOR PLASTICITY

资源核心 3：活动功能和神经运动可塑性

• 批准号: 8381752
• 负责人: ANDREW P GOLDBERG
• 金额: $ 15.18万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-15 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8381752
• 关键词: Affect; Aging; American; Area; Balance training; Behavioral; Biomechanics; Brain; Brain Stem; Chronic; Chronic Disease; Clinic; Cognitive; Communities; Community Practice; Complex; Computer Simulation; Coupled; Deterioration; Development; Disability phenotype; Disease; Elderly; Electroencephalography; Engineering; Equilibrium; Event; Exercise; Faculty; Functional disorder; Gait; Hip Fractures; Impairment; Individual; Instruction; Intervention; Joints; Laboratories; Lead; Learning; Life; Link; Locomotion; Measures; Mediating; Mentors; Metabolic syndrome; Methodology; Modeling; Morbidity - disease rate; Motor; Movement; Musculoskeletal Equilibrium; Neuronal Plasticity; Outcome; Parkinson Disease; Performance; Physiological; Process; Quality Control; Recovery of Function; Rehabilitation Research; Rehabilitation therapy; Research; Research Personnel; Resources; Robotics; Services; Spinal Cord; Stroke; System; Technology; Testing; Training; Translating; Upper Extremity; Validation; arm; base; clinically relevant; design; disability; functional gain; functional loss; improved; improved mobility; innovation; mortality; motor control; motor learning; multidisciplinary; neuroimaging; neuromuscular system; next generation; novel; prevent; rehabilitation strategy; response; sedentary; sensory feedback; tool; working group

The Mobility Function and Neuromotor Plasticity Core (RC-3) provides expertise and investigator resources to assess the multi-system neuromotor, blomeehanical, and motor behavioral factors affecting functional movement performance. RC-3 will assist and train RCDC Scholars and OAIC investigators in the design of novel rehabilitation interventions, conduct and interpretation of quantitative movement performance outcomes that are coupled to methodologies delineating the mechanisms of brain plasticity to advance the neuroscientific basis of functional recovery in older people with functional limitations. The Core supports: 1) a development project that examines the hypothesis that stabilizing responses to balance disturbances due to volitional movements primarily engage predictive and motor planning processes involving cortical and subcortical brain areas, while responses to reflexive balance disturbances due to unexpected external events primarily engage sensory feedback in the brainstem and spinal cord; 2) a PES that decodes the cortical electrophyslology of gait in stroke and older controls to characterize the dynamic neuromotor plasticity of locomotion, and another that investigates effects of split belt treadmill on locomotor re-learning after stroke; and 3) RCDC Scholar who will be mentoring in biomechanics, EEG and neuroimaging methodologies to study mechanisms of balance and mobility dysfunction in older people. RC-3 collaborates across OAIC cores in nresearch working groups to advance the next generation of interventions to the community that will enhance mobility function in older adults with chronic disability. It performs quality controlled tests of gait, balance, postural control, upper limb activities, and functional tasks (Toolbox) that characterize the processes of neuromotor control and plasticity that underlie motor learning and exercise derived functional gains across OAIC interventions. During the last 5 years, RC-3 provided core services to five PES, one DP and 6 external projects, mentored 2 RCDC Scholars and advanced testing methodology in neuromotor control and neuroimaging as well as developing new intervention methodologies.

移动功能和神经运动可塑性核心（RC-3）提供专业知识和研究人员资源，以评估影响功能性运动表现的多系统神经运动，生物力学和运动行为因素。RC-3将协助和培训RCDC学者和OAIC调查人员设计新的康复干预措施，进行和解释定量运动表现 这些结果与描绘大脑可塑性机制的方法相结合，以推进功能受限老年人功能恢复的神经科学基础。核心支持：1）一个研究假设的发展项目，即稳定对平衡干扰的反应， 意志运动主要涉及涉及皮质和皮质下脑区的预测和运动规划过程，而对由于意外外部事件引起的反射性平衡障碍的反应主要涉及脑干和脊髓中的感觉反馈; 2）解码中风和老年对照中步态的皮层电生理学以表征运动的动态神经运动可塑性的PES，另一个是研究分裂带跑步机对中风后运动再学习的影响; 3）RCDC学者，他将指导生物力学，脑电图和神经成像方法学，以研究老年人平衡和运动功能障碍的机制。RC-3在研究工作组的OAIC核心之间进行合作，以推进下一代社区干预措施，这将增强慢性残疾老年人的行动功能。它对步态、平衡、姿势控制、上肢活动和功能任务（工具箱）进行质量控制测试，这些测试表征了神经运动控制和可塑性的过程，这些过程是OAIC干预中运动学习和运动衍生功能增益的基础。在过去5年中，RC-3为5个PES、1个DP和6个外部项目提供了核心服务，指导了2名RCDC学者和神经运动控制和神经成像方面的先进测试方法，并开发了新的干预方法。