The Neurobiology of Social Decision-Making

社会决策的神经生物学

基本信息

批准号：
8286488
负责人：
RALPH ADOLPHS
金额：
$ 194.77万
依托单位：
CALIFORNIA INSTITUTE OF TECHNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-07-26 至 2017-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8286488
关键词：
Accounting Amygdaloid structure Architecture Autistic Disorder Basic Science Behavior Blood Brain Brain imaging Brain region Charities Child Collaborations Collection Communication Communities Competence Data Data Storage and Retrieval Decision Making Disease Dissection Education and Outreach Electric Stimulation Electrophysiology (science)Emotional Face Food Functional Magnetic Resonance Imaging Future Genetic Hospitals Human Human Resources Impairment Individual Differences Intervention Investigation Juice Learning Lesion Life Maps Mental Health Mind Monkeys Mood Disorders Neurobiology Neurosciences Outcome Participant Patients Persons Prefrontal Cortex Price Process Recruitment Activity Research Research Personnel Resources Rewards Sales Saliva Sampling Schizophrenia Science Social Functioning Staging Structure Students System Techniques Training Training Programs Work addiction base data sharing developmental disease experience human subject information processing insight neuroimaging neuropsychological nonhuman primate outreach program relating to nervous system research study reward processing social social neuroscience theories

项目摘要

This Conte Center resubmission will use a multi-modal, multi-species approach to investigate the neurobiological underpinnings of social decision-making. Three cores provide administrative, neuroimaging, and participant recruitment and assessment resources for four Projects that are each directed by internationally renowned leaders in social neuroscience and decision neuroscience, all of whom have a track record of scientific collaboration, student training, and expertise in the topic of the planned studies. The Projects constitute a cohesive set of experiments in humans and monkeys that will use the resources of the Caltech Brain Imaging Center for fMRI studies of the brain, existing collaborations with three hospitals for intracranial recordings in neurosurgical patients, together with the resources of labs at Caltech and at Cambridge for electrophysiological recordings in nonhuman primates. Project 1 provides a foundational investigation of basic social reward processing (e.g., representing the value of emotional faces), and how this compares with nonsocial reward processing (e.g., the value of juice). Project 2 investigates how we can learn choices by observing other people's decisions. Project 3 investigates how we can make decisions that are based on another person's value (such as in altruistic behaviors). Project 4 investigates the connectivity of the brain structures revealed by the other Projects to underlie social decision-making, such as the amygdala and parts of the prefrontal cortex. Each Project includes both fMRI and electrophysiology, and studies in both humans and monkeys. This science is woven into a training and outreach program emphasizing dissemination and diversity; and all data are made available for data sharing. The uniform recruitment and assessment of participants, the tight integration and communication between Projects, and the collaborative track record of the team will leverage these studies to a systematic and coordinated investigation of the largest outstanding questions in social decision-making, an enterprise that only a Conte Center mechanism could make possible.

此孔戴中心重新提交将使用多模式的多物种方法来研究社会决策的神经生物学基础。三个核心为四个项目提供了行政，神经影像学和参与者的招聘和评估资源，这些项目由国际知名的社会神经科学和决策神经科学领域的领导者指导，所有这些项目都有科学合作，学生培训以及计划研究主题的科学合作，学生培训和专业知识的记录。这些项目构成了人类和猴子的一系列凝聚力实验，这些实验将利用Caltech脑成像中心的资源进行大脑的fMRI研究中心，与三家医院合作，用于神经外科患者的颅内记录，以及在Caltech和Caltech的资源以及在剑桥和剑桥的资源中用于非杂志的剑桥唱片。项目1提供了基本的社会奖励处理（例如代表情感面孔的价值）的基本调查，以及如何将其与非社会奖励处理（例如果汁的价值）进行比较。项目2调查了我们如何通过观察他人的决定来学习选择。项目3调查了我们如何根据他人的价值做出决定（例如利他行为）。项目4调查了其他项目揭示的大脑结构的连通性，这些项目是社会决策基础的基础，例如杏仁核和前额叶皮层的一部分。每个项目都包括fMRI和电生理学，以及对人类和猴子的研究。该科学被编织成一个培训和推广计划，强调传播和多样性。并且所有数据均可用于数据共享。参与者的统一招聘和评估，项目之间的紧密整合和沟通以及团队的协作记录将利用这些研究来对社会决策中最大的杰出问题进行系统和协调的调查，这是一家只有孔戴中心机制才能实现的企业。