The Neurobiology of Social Decision-Making

社会决策的神经生物学

• 批准号: 8841000
• 负责人: RALPH ADOLPHS
• 金额: $ 192.23万
• 依托单位: CALIFORNIA INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-26 至 2016-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8841000
• 关键词: Accounting; Altruism; Amygdaloid structure; Architecture; Autistic Disorder; Basic Science; Behavior; Blood; Brain; Brain imaging; Brain region; Charities; Child; Collaborations; Collection; Communication; Communities; Competence; Data; Data Storage and Retrieval; Decision Making; Disease; Dissection; Education and Outreach; Electric Stimulation; Electrophysiology (science); Emotional; Face; Food; Functional Magnetic Resonance Imaging; Future; Genetic study; Hospitals; Human; Human Resources; Impairment; Individual Differences; Intervention; Investigation; Juice; Learning; Lesion; Life; Maps; Mental Health; Mind; Monkeys; Mood Disorders; Neurobiology; Neurosciences; Outcome; Participant; Patients; Persons; Prefrontal Cortex; Price; Process; Recruitment Activity; Research; Research Personnel; Resources; Rewards; Sales; Saliva; Sampling; Schizophrenia; Science; Social Functioning; Staging; Structure; Students; System; Techniques; Training; Training Programs; Work; addiction; base; data sharing; developmental disease; experience; human subject; information processing; insight; neuroimaging; neuropsychological; nonhuman primate; outreach program; relating to nervous system; research study; reward processing; social; social learning; social neuroscience; theories

This Conte Center resubmission will use a multi-modal, multi-species approach to investigate the neurobiological underpinnings of social decision-making. Three cores provide administrative, neuroimaging, and participant recruitment and assessment resources for four Projects that are each directed by internationally renowned leaders in social neuroscience and decision neuroscience, all of whom have a track record of scientific collaboration, student training, and expertise in the topic of the planned studies. The Projects constitute a cohesive set of experiments in humans and monkeys that will use the resources of the Caltech Brain Imaging Center for fMRI studies of the brain, existing collaborations with three hospitals for intracranial recordings in neurosurgical patients, together with the resources of labs at Caltech and at Cambridge for electrophysiological recordings in nonhuman primates. Project 1 provides a foundational investigation of basic social reward processing (e.g., representing the value of emotional faces), and how this compares with nonsocial reward processing (e.g., the value of juice). Project 2 investigates how we can learn choices by observing other people's decisions. Project 3 investigates how we can make decisions that are based on another person's value (such as in altruistic behaviors). Project 4 investigates the connectivity of the brain structures revealed by the other Projects to underlie social decision-making, such as the amygdala and parts of the prefrontal cortex. Each Project includes both fMRI and electrophysiology, and studies in both humans and monkeys. This science is woven into a training and outreach program emphasizing dissemination and diversity; and all data are made available for data sharing. The uniform recruitment and assessment of participants, the tight integration and communication between Projects, and the collaborative track record of the team will leverage these studies to a systematic and coordinated investigation of the largest outstanding questions in social decision-making, an enterprise that only a Conte Center mechanism could make possible.

这次Conte中心的重新提交将使用多模式，多物种的方法来调查社会决策的神经生物学基础。三个核心为四个项目提供行政，神经成像和参与者招募和评估资源，每个项目都由社会神经科学和决策神经科学的国际知名领导者指导，他们都有科学合作，学生培训和专业知识的跟踪记录。这些项目包括一系列在人类和猴子身上进行的实验，这些实验将利用加州理工学院脑成像中心的资源对大脑进行功能磁共振成像研究，与三家医院合作对神经外科患者进行颅内记录，以及利用加州理工学院和剑桥实验室的资源对非人类灵长类动物进行电生理记录。项目1提供了一个基本的社会奖励处理的基础调查（例如，表示情绪面孔的价值），以及这与非社会奖励处理（例如，果汁的价值）。项目2研究我们如何通过观察别人的决定来学习选择。项目3研究我们如何根据他人的价值做出决定（例如利他行为）。项目4研究了其他项目揭示的大脑结构的连通性，以支持社会决策，如杏仁核和部分前额叶皮层。每个项目都包括fMRI和电生理学，以及对人类和猴子的研究。这门科学被纳入一个强调传播和多样性的培训和推广计划;所有数据都可用于数据共享。参与者的统一招募和评估，项目之间的紧密整合和沟通，以及团队的协作记录将利用这些研究来系统和协调地调查社会决策中最大的突出问题，只有Conte中心机制才能使之成为可能。