The Neurobiology of Social Decision-Making

社会决策的神经生物学

• 批准号: 8841000
• 负责人: RALPH ADOLPHS
• 金额: $ 192.23万
• 依托单位: CALIFORNIA INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-26 至 2016-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8841000
• 关键词: Accounting; Altruism; Amygdaloid structure; Architecture; Autistic Disorder; Basic Science; Behavior; Blood; Brain; Brain imaging; Brain region; Charities; Child; Collaborations; Collection; Communication; Communities; Competence; Data; Data Storage and Retrieval; Decision Making; Disease; Dissection; Education and Outreach; Electric Stimulation; Electrophysiology (science); Emotional; Face; Food; Functional Magnetic Resonance Imaging; Future; Genetic study; Hospitals; Human; Human Resources; Impairment; Individual Differences; Intervention; Investigation; Juice; Learning; Lesion; Life; Maps; Mental Health; Mind; Monkeys; Mood Disorders; Neurobiology; Neurosciences; Outcome; Participant; Patients; Persons; Prefrontal Cortex; Price; Process; Recruitment Activity; Research; Research Personnel; Resources; Rewards; Sales; Saliva; Sampling; Schizophrenia; Science; Social Functioning; Staging; Structure; Students; System; Techniques; Training; Training Programs; Work; addiction; base; data sharing; developmental disease; experience; human subject; information processing; insight; neuroimaging; neuropsychological; nonhuman primate; outreach program; relating to nervous system; research study; reward processing; social; social learning; social neuroscience; theories

This Conte Center resubmission will use a multi-modal, multi-species approach to investigate the neurobiological underpinnings of social decision-making. Three cores provide administrative, neuroimaging, and participant recruitment and assessment resources for four Projects that are each directed by internationally renowned leaders in social neuroscience and decision neuroscience, all of whom have a track record of scientific collaboration, student training, and expertise in the topic of the planned studies. The Projects constitute a cohesive set of experiments in humans and monkeys that will use the resources of the Caltech Brain Imaging Center for fMRI studies of the brain, existing collaborations with three hospitals for intracranial recordings in neurosurgical patients, together with the resources of labs at Caltech and at Cambridge for electrophysiological recordings in nonhuman primates. Project 1 provides a foundational investigation of basic social reward processing (e.g., representing the value of emotional faces), and how this compares with nonsocial reward processing (e.g., the value of juice). Project 2 investigates how we can learn choices by observing other people's decisions. Project 3 investigates how we can make decisions that are based on another person's value (such as in altruistic behaviors). Project 4 investigates the connectivity of the brain structures revealed by the other Projects to underlie social decision-making, such as the amygdala and parts of the prefrontal cortex. Each Project includes both fMRI and electrophysiology, and studies in both humans and monkeys. This science is woven into a training and outreach program emphasizing dissemination and diversity; and all data are made available for data sharing. The uniform recruitment and assessment of participants, the tight integration and communication between Projects, and the collaborative track record of the team will leverage these studies to a systematic and coordinated investigation of the largest outstanding questions in social decision-making, an enterprise that only a Conte Center mechanism could make possible.

这次孔特中心的重新提交将使用多模式、多物种的方法来调查社会决策的神经生物学基础。三个核心为四个项目提供行政、神经成像、参与者招募和评估资源，每个项目都由社会神经科学和决策神经科学领域的国际知名领导者指导，他们都有在计划研究主题方面的科学合作、学生培训和专业知识的记录。这些项目构成了一套连贯的人类和猴子实验，将利用加州理工学院脑成像中心的资源进行大脑的功能磁共振研究，现有的与三家医院合作的神经外科患者的颅内记录，以及加州理工大学和剑桥大学的实验室资源，用于非人类灵长类动物的电生理记录。项目1提供了对基本的社会奖励处理(例如，代表情绪面孔的价值)的基础调查，以及这与非社会奖励处理(例如，果汁的价值)的比较。项目2调查了我们如何通过观察别人的决定来学习选择。项目3调查了我们如何根据他人的价值(例如在利他行为中)做出决定。项目4调查了其他项目揭示的作为社会决策基础的大脑结构的连通性，如杏仁核和部分前额叶皮质。每个项目都包括功能磁共振成像和电生理学，以及对人类和猴子的研究。这一科学被编织到一个强调传播和多样性的培训和推广计划中；所有数据都可用于数据共享。参与者的统一征聘和评估、项目之间的紧密整合和沟通以及团队的协作记录将利用这些研究对社会决策中最大的悬而未决的问题进行系统和协调的调查，这是一个只有孔特中心机制才能实现的企业。