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The Neurobiology of Social Decision-Making: Social Inference and Context

社会决策的神经生物学：社会推理和背景

基本信息

批准号：
9475305
负责人：
RALPH ADOLPHS
金额：
$ 187.09万
依托单位：
CALIFORNIA INSTITUTE OF TECHNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-07-26 至 2022-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9475305
关键词：
Address Altruism Autistic Disorder Basic Science Behavior Belief Biological Brain Brain region Buffers Collaborations Communication Cues Data Decision Making Diagnosis Disease Dissection Electrophysiology (science)Enrollment Epilepsy Faculty Financial compensation Functional Magnetic Resonance Imaging Functional disorder Goals Human Implanted Electrodes Individual Differences International Intervention Investigation Learning Lesion Life Link Mental Health Mental disorders Modeling Monitor Monkeys Mood Disorders Neurobiology Participant Patient Recruitments Patients Persons Play Postdoctoral Fellow Prefrontal Cortex Process Psychological reinforcement Registries Resources Rewards Schizophrenia Science Series Structure System Testing Training Programs Work addiction autism spectrum disorder base behavioral study brain machine interface computer framework contextual factors data sharing experience fictional works human subject innovation insight multimodality neural prosthesis neurobiological mechanism neuroimaging novel outreach program preference recruit relating to nervous system senior faculty social social group social learning student training

项目摘要

OVERVIEW. Project Summary. This renewal application of a basic research Conte Center aims to elucidate the neurobiological mechanisms for social decision-making in humans. While our current Conte Center investigated the basic systems for decision-making, and did so in both humans and monkeys, this renewal now focuses only on humans, and on more translationally relevant questions. In particular, we now focus on how social inference and context come into play. How do we attribute internal states, such as values, beliefs, and intentions, to other people? How does this depend on the context in which we observe those other people? How does it influence how we can learn from others, how we make altruistic decisions about them, how we deal with social threat? This set of new questions builds directly on our current Conte Center, and is of critical translational importance for understanding deficits in social decision-making such as those that occur in autism spectrum disorders and other psychiatric illnesses. Three cores provide administrative, neuroimaging, and participant recruitment and assessment resources for five Projects that are each directed by internationally renowned leaders, all of whom have a track record of scientific collaboration, student training, and expertise in the topic of the planned studies. Unique innovative strengths of this application are the combination of neuroimaging, intracranial electrophysiology, and lesion studies in human subjects. Cross-cutting questions can be addressed with this multimodal approach, which includes neuroimaging in the very same subjects from whom we record electrophysiologically, and in lesion subjects. Project 1 begins by investigating how social inference and context guides social learning. Projects 2 and 3 examine how social inference modulates social decision-making, in either prosocial, altruistic contexts (Project 2) or under social threat (Project 3). Project 4 examines these questions in relation to how we represent other people and ourselves, using single-unit recordings. Project 5 focuses on lesion studies of the prefrontal cortex, which is the brain region most closely involved in the processes under investigation. This science is woven into a training and outreach program emphasizing dissemination and diversity; and all data are made available for data sharing. The uniform recruitment and assessment of participants, the tight integration and communication between Projects, and the collaborative track record of the team will leverage these studies to a systematic and coordinated investigation of the largest outstanding questions in social decision-making. Progress on this topic will be an essential component for better diagnoses and treatments for a range of psychiatric disorders, including autism, addiction, and mood disorders.

概述。项目总结。