Physically-Based Biodosimetry for Triage After a Large Radiation Incident

大型辐射事件后基于物理的生物剂量测定

基本信息

  • 批准号:
    8310087
  • 负责人:
  • 金额:
    $ 321.86万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2010
  • 资助国家:
    美国
  • 起止时间:
    2010-08-15 至 2015-07-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): We propose to establish a center focused on the development of field deployable physical biodosimetry utilizing EPR measurements of teeth and nails through three synergistic projects and highly integrated cores based on prior progress. The rationale for our approach we believe is compelling though relatively simple. 1. In order to respond adequately to a radiation incident in which large numbers of individuals potentially have received doses of radiation that could lead to the acute radiation syndrome it is essential to determine the dose to individuals rapidly and accurately. 2. The current capabilities and guidelines are not adequate for doing this. 3. The dosimetry system should be based on radiation induced changes within the individual so that a "dosimeter" is always in place, i.e. biodosimetry is needed. 4. Biologically based biodosimetry, while potentially very valuable, inherently must have ambiguity because it depends on the activation of responses to injury that are not specific for ionizing radiation, must vary in time as the responses are developed and later attenuated, and are very likely to be affected by both pre-existing conditions and concurrent perturbations such as stress, wounds, and burns. 5. Physical biodosimetry does not have the potential limitations of the biologically based biodosimetry. 6. EPR dosimetry based on radiation-induced changes in teeth and nails is the most advanced physical biodosimetric technique and has been shown to be capable of resolving doses in the range of interest with immediate readout. 7. Our group has led the development of such EPR dosimetry and is poised to make it into a field deployable technique that can be implemented by non-expert operators without any prior training. We will complete the development of the techniques and construct field-deployable prototypes of instruments based on three different and complimentary approaches: measurements in vivo in teeth, measurements in vivo in nails, and measurements in vitro on clipped fingernails. We expect these applications to be part of a multimodality approach to field dosimetry, complementing biological biodosimetry. We have potential commercial partners, especially General Electric, who is prepared to use the prototypes to carry out rapid FDA-compliable production of fully deployable versions as soon as the prototypes are available from the proposed center.
描述(由申请人提供):我们建议建立一个中心,通过三个协同项目和基于先前进展的高度集成的核心,利用牙齿和指甲的EPR测量来开发现场可部署的物理生物剂量学。我们认为,我们采取这种做法的理由是令人信服的,尽管相对简单。1.为了对可能导致急性辐射综合症的大量个人可能受到辐射剂量的辐射事件作出适当反应,必须迅速和准确地确定个人受到的剂量。2.目前的能力和指导方针不足以做到这一点。3.剂量学系统应以辐射引起的个体内变化为基础,以便始终有“剂量计”,即需要生物剂量学。4.基于生物的生物剂量测定虽然潜在非常有价值,但本质上必须具有模糊性,因为它依赖于对伤害的反应的激活,而这些反应不是电离辐射所特有的,必须随着反应的发展和后来的减弱而随时间变化,并且很可能受到预先存在的条件和同时存在的扰动(如应激、创伤和烧伤)的影响。5.物理生物剂量学不具有基于生物的生物剂量学的潜在局限性。6.基于辐射引起的牙齿和指甲变化的EPR剂量测定是最先进的物理生物剂量测定技术,已被证明能够在感兴趣的范围内立即读出剂量。7.我们小组领导了这种EPR剂量测量的开发,并准备使其成为一项可现场部署的技术,非专家操作员无需任何事先培训即可实施。我们将完成这些技术的开发,并基于三种不同和互补的方法构建可现场展开的仪器原型:在体牙齿测量、在体指甲测量和修剪指甲的体外测量。我们期望这些应用成为野外剂量学多模式方法的一部分,补充生物剂量学。我们有潜在的商业合作伙伴,特别是通用电气,一旦原型从拟议的中心获得,他们就准备使用原型进行符合FDA要求的完全可部署版本的快速生产。

项目成果

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HAROLD M SWARTZ其他文献

HAROLD M SWARTZ的其他文献

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{{ truncateString('HAROLD M SWARTZ', 18)}}的其他基金

Core 1: Scientific/Administrative Support Shared Resource
核心 1:科学/行政支持共享资源
  • 批准号:
    8795072
  • 财政年份:
    2015
  • 资助金额:
    $ 321.86万
  • 项目类别:
Direct and Repeated Clinical Measurement of pO2 for Enhancing Cancer Therapy
直接和重复的 pO2 临床测量可增强癌症治疗
  • 批准号:
    8795071
  • 财政年份:
    2015
  • 资助金额:
    $ 321.86万
  • 项目类别:
Project 3: Direct & Repeated Measurement of pO2 in Deep-seated Tumors using EPR O
项目3:直接
  • 批准号:
    8795077
  • 财政年份:
    2015
  • 资助金额:
    $ 321.86万
  • 项目类别:
Physically-Based Biodosimetry for Triage After a Large Radiation Incident
大型辐射事件后基于物理的生物剂量测定
  • 批准号:
    8705999
  • 财政年份:
    2010
  • 资助金额:
    $ 321.86万
  • 项目类别:
Biodosimetry based on EPR measurements of nails in vivo: Dartmouth Medical School
基于体内指甲 EPR 测量的生物剂量测定:达特茅斯医学院
  • 批准号:
    8013158
  • 财政年份:
    2010
  • 资助金额:
    $ 321.86万
  • 项目类别:
Physically-Based Biodosimetry for Triage After a Large Radiation Incident
大型辐射事件后基于物理的生物剂量测定
  • 批准号:
    8522138
  • 财政年份:
    2010
  • 资助金额:
    $ 321.86万
  • 项目类别:
Physically-Based Biodosimetry for Triage After a Large Radiation Incident
大型辐射事件后基于物理的生物剂量测定
  • 批准号:
    8009575
  • 财政年份:
    2010
  • 资助金额:
    $ 321.86万
  • 项目类别:
Physically-Based Biodosimetry for Triage After a Large Radiation Incident
大型辐射事件后基于物理的生物剂量测定
  • 批准号:
    8127903
  • 财政年份:
    2010
  • 资助金额:
    $ 321.86万
  • 项目类别:
Scientific and Administrative Core: Dartmouth Medical School
科学和行政核心:达特茅斯医学院
  • 批准号:
    8013159
  • 财政年份:
    2010
  • 资助金额:
    $ 321.86万
  • 项目类别:
BioDose-08 Conference
BioDose-08 会议
  • 批准号:
    7486040
  • 财政年份:
    2008
  • 资助金额:
    $ 321.86万
  • 项目类别:

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