Core 1: Scientific/Administrative Support Shared Resource

核心1摘要 所有这三个项目和PPG的核心将得到行政和科学部门的支持。 支助核心，其主要职能是促进和协调三个地点的工作， 统一的方式，以促进最大的科学有效性，临床意义， 测量结果的适用性。这种协调尤其重要 考虑到测量程序和肿瘤类型的潜在差异， 不同的地理位置和不同的项目。这也将促进资源共享， 跨站点传播信息。每个项目PI将负责 协调和科学规划，但预计将作出反应， 来自总体PI、其他项目和核心的PI的建议和其他输入， 和咨询委员会。核心1的具体任务是： 管理和协调三个项目的科学计划。核心 将实施有效的规划，实施和科学的管理计划 在项目和项目现场的项目。这将由管理团队完成， 包括PI（Swartz）、项目PI和核心PI，以及 咨询委员会。这包括组织和举办项目规划小组的年度会议。我们 将建立有效的沟通机制，包括每周、每月和每年 现场内和现场间参加的会议。将定期报告进展情况和计划， 预计每3个月进行一次，总结结果，未来几个月的计划，以及潜在的 已发现的障碍或问题。 支持临床研究，包括协调和保证定性 测量程序的标准化，特别是 人类受试者，以及保证血氧测定材料的标准制备/处理。 核心小组将在协调和协调联合国系统各机构的复杂任务方面提供具体的专门知识和协助。 促进临床层面的合作研究。其目的是让结果从 每个项目内部和项目之间的不同研究具有足够的共性， 它们有助于实现PPG和项目的总体目标。我们将建立 在与各研究中心合作时，制定测量的通用SOP，以确保 满足当地条件所需的资源已经到位，并与联合国的总体目标保持一致。 PPG。我们将为参与的人员提供必要的教育和培训， 项目/现场的测量和程序。核心还将建立 执行操作的程序，以确保测量数据的质量和完整性。 核心还将建立和维护一个中央数据档案。 后勤支援。这包括全面的财务管理，行政支持， 项目和核心，并定期向NCI提供进度报告。它还将支持 为演讲和出版物准备材料。核心将协调旅行使用 中央差旅预算，用于支付所有项目和核心活动的差旅费，包括年度会议的差旅费。

ABSTRACT FOR CORE 1 All three projects and the cores of the PPG will be supported by an administrative and scientific support core, whose main function is to facilitate and coordinate the work at the three sites in a unified manner to facilitate maximal scientific validity, clinical significance, and clinical applicability of the results of the measurements. Such coordination is particularly important considering the potential differences in the measurement procedures and tumor types at different geographic sites and in different projects. This also will facilitate resource sharing and dissemination of information across sites. Each project PI will have responsibility for the coordination and scientific planning at the level of their projects, but will be expected to respond to the suggestions and other input from the overall PI, the PIs of the other projects and cores, and the advisory committee. The specific tasks of Core 1 are: Management and coordination of the scientific programs of the three projects. The core will implement a plan for effective planning, implementation, and management of scientific programs across the projects and project sites. This will be done by the management team that includes the PI (Swartz), and Project PIs, and Core PIs, with input from members of the advisory committees. This includes organizing and running the annual meetings of the PPG. We will establish effective communication mechanisms including weekly, monthly, and annual meetings with intra- and inter-site participation. Periodic reports of progress and pans will be expected at 3 month intervals, summarizing results, plans for the next few months, and potential obstacles or problems that have been identified. Support of clinical studies including coordination and assurance of qualitative standardization of measurement procedures, especially the protocols for the studies in human subjects, and assurance of standard preparation/handling of oximetric materials. The core will provide specific expertise and assistance in the complex task of coordinating and facilitating cooperative investigations at the clinical level. The aim is to allow the results from the different studies within each project and between projects to have sufficient commonality that they contribute toward meeting the overall goals of the PPG and of the project. We will establish common SOPs for the measurements while working with each site to assure that the variations needed to meet local conditions are in place and remain compatible with the overall goals of the PPG. We will provide the necessary education and training to the personnel involved in the measurements and procedures across the projects/sites. The core will also establish procedures for carrying out the operations to assure quality and integrity of the data measured. The core also will establish and maintain a central data archive. Logistical support. This include overall financial management, administrative support for all projects and cores, and providing periodic progress reports to the NCI. It also will support the preparation of materials for presentations and publications. The core will coordinate travel using a central travel budget to cover travel for all projects and cores including for the annual meeting.