Scientific and Administrative Core: Dartmouth Medical School

这一核心提供了影响整个中心的科学和行政支持。它提供了 科学的管理和财务管理对于中心的有效和负责任的运作至关重要。这一核心将支持组织方面，使研究能够以综合和协同的方式进行，并进行良好的沟通，包括获得和利用与个别项目和整个中心有关的建议的渠道。它还提供了一些关键的总体投入和支持，直接推动科学发展，并导致建设能力，这是该中心的总体目标。后者包括：1)复杂的生物统计支持和2)对工具开发的指导，使其结合充分运作的技术能力和在可能利用它们的环境中有效运作的能力。制定预算是为了促进该核心履行其对整个项目的责任的能力：开发优化的关键组件，以在 所有三个项目，然后开发一个原型，将这些发展纳入所有三个项目的实地可部署工具。这一核心中的人员承担着跨越所有三个项目的特定职责，并且还包含来自其他核心的概念、软件和硬件。他们对每个项目也有具体的责任。如实验研究计划所述，这一核心的人员将参与三个项目的日常运作，特别是开发专门的仪器，以促进每个项目。因为三个项目之间的时间承诺会随着时间的推移而变化，在这个核心中的个人之间，最有效的做法是不试图说明他们在三个项目上所做的努力的固定比例。相反，我们将有能力和灵活性来提供在所有三个项目中实现最大进展所需的努力，并将能够 更快地推进能够最快实现现场可部署性的项目。作为一个粗暴的人 据估计，项目1和项目3(在达特茅斯)的直接项目支助活动将各占40%，以佛罗里达州为中心的项目2将占20%，尽管项目2的大量工作计划也将在项目2的PI的直接指导下在达特茅斯进行。在赠款期间，该核心的人员将花费越来越多的时间和精力来设计、建造和测试将要生产的原型仪器。项目人员将密切参与设计和测试阶段。

This core provides scientific and administrative support that impacts the entire Center. It provides the scientific management and financial management essential for the effective and responsible operation of the Center. This core will support the organizational aspects that enable the research to be carried out in an integrated and synergistic manner, with excellent communication including channels for obtaining and utilizing advice that pertains both to individual projects and the center as a whole. It also provides some key over-arching input and support that directly advance the scientific developments and lead to the construction ofthe capabilities that are the overall goal ofthe Center. The latter include: 1) sophisticated biostatistical support and 2) guidance of the development of the instruments so that they combine both fully operational technical capabilities and the ability to operate effectively in the environment in which they are likely to be utilized. The budget has been developed to facilitate the capabilities of this core carrying out its responsibilities forthe overall project: to develop optimized critical components to advance the technology in all three projects and then to develop a prototype that incorporates the developments into field deployable instruments for all three projects. The personnel in this core have specific responsibilities that extend across all three projects and also incorporate concepts, software, and hardware from the other cores. They also have specific responsibilities with I each project. As noted within the experimental research plans the personnel in this core will be involved in the day to day operations of the three projects, especially in the development ofthe specialized instrumentation to facilitate each project. Because the time commitments among the three projects will vary over time and among individuals in this core, it is most efficient to not to try to indicate a set proportion of their efforts for the three projects. Instead we will have the capability and the flexibility to provide the effort that is need to attain maximal progress in all three projects and will be able to advance more quickly projects where the field deployability can be achieved most rapidly. As a rough estimate, the direct project-supporting activities will be roughly 40% each for Projects 1 and 3 (these are at Dartmouth) and 20% for Project 2 which is centered at Florida although there also will be a significant amount of the work plan for Project 2 carried out at Dartmouth under the direct guidance of the PI of project 2. During the course of the grant period the personnel in this core will be spending an increasing amount of their time and effort in the design, construction, and testing ofthe prototype instruments to be produced. The personnel of the projects will be closely involved in both the design and the testing phases.