Ontogeny and neural basis of social visual engagement in monkeys

猴子社会视觉参与的个体发育和神经基础

• 批准号: 8426654
• 负责人: JOCELYNE H BACHEVALIER
• 金额: $ 46.24万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8426654
• 关键词: Address; Age; Amygdaloid structure; Animal Model; Animals; Area; Attenuated; Autistic Disorder; Behavior; Behavioral; Biological Models; Biological Neural Networks; Birth; Brain; Brain Mapping; Brain scan; Clip; Cognitive; Complex; Cues; Data; Data Analyses; Detection; Development; Diagnosis; Disease; Environment; Eye; Eye Movements; Functional Magnetic Resonance Imaging; Future; Gene Targeting; Genes; Goals; Growth; Human; Human Development; Infant; Instruction; Knowledge; Life; Longitudinal Studies; Macaca mulatta; Measures; Mediating; Methodology; Modeling; Monkeys; Mothers; Neurobiology; Parietal Lobe; Pathway interactions; Pattern; Phenotype; Phylogeny; Population; Prefrontal Cortex; Principal Investigator; Procedures; Process; Research; Resolution; Risk; Sampling; Scanning; Series; Signal Transduction; Social Development; Social Interaction; Source; Staging; Structure; System; Techniques; Testing; Therapeutic; Toddler; Transgenic Organisms; Translating; Translational Research; Visual; Work; base; brain behavior; cognitive function; computer monitor; critical period; developmental disease; infancy; instrument; male; neuroimaging; neuropsychological; nonhuman primate; preference; relating to nervous system; resilience; sample fixation; scaffold; skills; social; social group; social integration; social skills; sound; tool; visual search

Autism is a disorder deflned by altered engagement with the social worid that emerges at eariy stages ofthe disorder. Thus, increase knowledge on the crifical periods of typical development during which these eariy social skills emerge and mature and on the underiying neurobiological systems that underiie these skills will give unprecedented opportunity to further understand the neurobiological source of the eariy diagnosis markers of autism. Although research examining the precursors of human social abilities during eariy infancy has significantly increased in the last few years, critical information on the neural substrates that support these eariy developing social skills is still lacking. One ofthe main reasons being the limitafions in neuroimaging the human brain in infancy, and to study brain-behavior relafionship across development using longitudinal studies. Thus, knowledge in this domain must emerge from translational research examining both human populafions and animal models. Rhesus monkeys provide a remarkable opportunity in this domain given (1) the rich and complex social structure in which they develop and navigate, (2) the progressive development of the basic social skills required to develop normal social relationships, and (3) the similarity with humans in brain and cognitive functions development. Thus, Aim 1 will follow longitudinally the development of social visual engagement processes, including attenfion to, detection and integrafion of social signals in normally developing rhesus monkeys from birth to 6 months, using neuropsychological "marker" tasks similar to those employed in the typical and atypical human population (Project I) to facilitate cross-species comparisons. This will allow defining significant crifical periods during which these processes emerge and refine. Aim 2 will investigate in the same animals the maturafional changes in brain networks mediafing these basic social processes using noninvasive neuroimaging procedures. These studies on the normally developing rhesus monkeys will provide unparalleled information and a critical non-human primate model that could be used for further invesfigafions targeting gene-behavior relafionships and therapeutic intervenfions. RELEVANCE (See instructions): This multifaceted project will provide much needed normative data on the development of social engagement and ecologically valid procedures to be used to assess the phenotype of transgenic monkeys and validate their relevance as an animal model of autism (Project IV) and in future studies to assess potential treatment. This innovafive project will significantly impact studies of the causes, neural bases, and potential treatment not only for autism but also for other human developmental disorders associated with atypical social skills.

自闭症是一种通过改变对社会世界的参与而产生的一种障碍，这种改变出现在自闭症的早期阶段 无序。因此，增加对典型发育的关键时期的认识，在此期间，这些早期 社交技能的出现和成熟，以及这些技能背后的神经生物系统将 为进一步了解早期诊断的神经生物学来源提供了前所未有的机会 自闭症的标志。尽管在早期研究人类社会能力的先驱 在过去的几年里，婴儿期显著增加，神经底物上的关键信息 对这些早期发展的社交技能的支持仍然缺乏。其中一个主要原因是 对婴儿期的人类大脑进行神经成像，并研究大脑行为与发育的关系 采用纵向研究。因此，这个领域的知识必须从翻译研究中产生 研究人类人口和动物模型。恒河猴提供了一个难得的机会 在这个领域，(1)他们在丰富和复杂的社会结构中发展和导航，(2) 逐步发展发展正常社会关系所需的基本社交技能；及(3) 在大脑和认知功能发育方面与人类相似。因此，目标1将会遵循 纵向发展社交视觉参与过程，包括关注、发现和 正常发育恒河猴从出生到6个月的社会信号整合 类似于典型人群和非典型人群的神经心理“标记”任务 (项目一)促进跨物种比较。这将允许在以下期间定义重要的危急时期 这些过程产生并提炼了它们。目标2将在相同的动物身上研究成熟的 使用非侵入性神经成像技术调节这些基本社会过程的大脑网络的变化 程序。这些对正常发育的恒河猴的研究将提供无与伦比的信息 以及一个关键的非人类灵长类动物模型，可以用于进一步研究针对基因行为的研究 重建关系和治疗干预。 相关性(请参阅说明)： 这一多方面的项目将提供社会发展方面亟需的规范数据。 用于评估转基因猴子表型的参与和生态上有效的程序 并验证它们作为自闭症动物模型的相关性(项目IV)以及在未来的研究中评估 潜在的治疗方法。这一创新五计划将显著影响对病因、神经基础和 不仅可以治疗自闭症，还可以治疗其他与自闭症相关的人类发育障碍 非典型的社交技能。