Delaware INBRE

特拉华州INBRE更新提案的目标是朝着改善健康迈出又一大步 通过扩大目前INBRE在建立全州范围的生物医学研究方面的工作， 能力。该项目将继续加强牵头机构的研究专长和基础设施， 伙伴机构。将开展三项研究。一个癌症项目，开始于目前的 INBRE将重点关注癌细胞的移动性，特定蛋白在转移中的作用，DNA修复和 用于癌症治疗的生物材料。一项新的心血管计划将重点关注细胞外基质 心力衰竭的重塑和心脏组织工程的生物材料。一项新的神经科学计划将 解决学习和记忆、脊髓性肌萎缩和心血管疾病的分子机制 糖尿病的自主神经功能资助初级教师、博士后和研究生 参与每个研究主题内的研究项目，提供。研究主题是 由目前INBRE下开发的全州生物医学基础设施支持，但 大大增强了生物信息学和集中式仪器核心。本科生研究 和专业发展核心将为来自国家的学生提供研究机会 本科院校和社区学院，从而发展学生追求的管道 在医疗保健行业的职业生涯，提高国家的劳动力的技术知识。

The goal of the Delaware INBRE renewal proposal is to take another major step towards improving health care in the State by extending the work of the current INBRE in building a statewide biomedical research capability. The project will continue to strengthen the research expertise and infrastructure of the lead and partner institutions. Three research themes will be pursued. A cancer program, begun under the current INBRE, will focus on cancer cell mobility, the role of specific proteins in metastasis, DNA repair and biomaterials for use in cancer treatments. A new cardiovascular program will focus on extra-cellular matrix remodeling in heart failure and biomaterials for cardiac tissue engineering. A new neuroscience program will address molecular mechanisms of learning and memory, spinal muscular atrophy and cardiovascular autonomic nerve function in diabetes. Funds to support junior faculty, postdoctoral and graduate students engaged in the research projects within each research theme, are provided. The Research Themes are supported by a statewide biomedical infrastructure developed under the current INBRE, but with considerably enhanced Bioinformatics and Centralized Instrumentation Cores. An Undergraduate Research and Professional Development Core will provide research opportunities for students from the State's undergraduate institutions and community colleges, thereby developing a pipeline of students pursuing careers in the health care industry and enhancing the technical knowledge of the State's workforce.