Delaware INBRE

特拉华州INBRE

• 批准号: 8456157
• 负责人: Steven J. Stanhope
• 金额: $ 331.16万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8456157
• 关键词: Address; American; Area; Biocompatible Materials; Bioinformatics; Biomedical Research; Breast; Cardiac; Cardiovascular system; Cell Mobility; Cytoskeleton; DNA Repair; Data; Delaware; Development; Diabetes Mellitus; Disease; Faculty; Foundations; Funding; Generations; Goals; Grant; Health; Healthcare; Healthcare Industry; Heart Diseases; Heart failure; Institution; Knowledge; Lead; Learning; Malignant Neoplasms; Memory; Methods; Molecular; Neoplasm Metastasis; Neurosciences; Proteins; Research; Research Infrastructure; Research Personnel; Research Project Grants; Role; Scientist; Seeds; Spinal Muscular Atrophy; Students; Surface; Tissue Engineering; Work; autonomic nerve; cancer cell; cancer therapy; career; community college; graduate student; improved; instrumentation; programs; reconstruction; undergraduate research

The goal of the Delaware INBRE renewal proposal is to take another major step towards improving health care in the State by extending the work of the current INBRE in building a statewide biomedical research capability. The project will continue to strengthen the research expertise and infrastructure of the lead and partner institutions. Three research themes will be pursued. A cancer program, begun under the current INBRE, will focus on cancer cell mobility, the role of specific proteins in metastasis, DNA repair and biomaterials for use in cancer treatments. A new cardiovascular program will focus on extra-cellular matrix remodeling in heart failure and biomaterials for cardiac tissue engineering. A new neuroscience program will address molecular mechanisms of learning and memory, spinal muscular atrophy and cardiovascular autonomic nerve function in diabetes. Funds to support junior faculty, postdoctoral and graduate students engaged in the research projects within each research theme, are provided. The Research Themes are supported by a statewide biomedical infrastructure developed under the current INBRE, but with considerably enhanced Bioinformatics and Centralized Instrumentation Cores. An Undergraduate Research and Professional Development Core will provide research opportunities for students from the State's undergraduate institutions and community colleges, thereby developing a pipeline of students pursuing careers in the health care industry and enhancing the technical knowledge of the State's workforce.

特拉华州INBRE更新提案的目标是朝着改善健康迈出又一大步

项目成果

In vitro hybridization and separation of hybrids of human adenylosuccinate lyase from wild-type and disease-associated mutant enzymes.

• DOI: 10.1021/bi101734q
• 发表时间: 2011-03-01
• 期刊: Biochemistry
• 影响因子: 2.9
• 作者: De Zoysa Ariyananda L;Antonopoulos C;Currier J;Colman RF
• 通讯作者: Colman RF

Tunable degradation of maleimide-thiol adducts in reducing environments.

• DOI: 10.1021/bc200148v
• 发表时间: 2011-10-19
• 期刊: BIOCONJUGATE CHEMISTRY
• 影响因子: 4.7
• 作者: Baldwin, Aaron D.;Kiick, Kristi L.
• 通讯作者: Kiick, Kristi L.

Detailed Analysis for the Solvolysis of Isopropenyl Chloroformate.

• DOI: 10.5155/eurjchem.2.2.130-135.405
• 发表时间: 2011-06
• 期刊: European journal of chemistry (Print)
• 作者: D'Souza MJ;Shuman KE;Omondi AO;Kevill DN
• 通讯作者: Kevill DN

A Database Developed with Information Extracted from Chemotherapy Drug Package Inserts to Enhance Future Prescriptions.

利用从化疗药物包装插入中提取的信息开发的数据库，以增强未来的处方。

• 发表时间: 2011
• 期刊: Conference on Computer Vision and Pattern Recognition Workshops. IEEE Computer Society Conference on Computer Vision and Pattern Recognition. Workshops
• 作者: D'Souza,MalcolmJ;Alabed,GhadaJ;Wheatley,JordanM;Roberts,Natalia;Veturi,Yogasudha;Bi,Xia;Continisio,ChristopherHart
• 通讯作者: Continisio,ChristopherHart

Chlorobaculum tepidum TLS displays a complex transcriptional response to sulfide addition.

温热绿杆菌 TLS 对硫化物添加表现出复杂的转录反应。

• DOI: 10.1128/jb.01342-12
• 发表时间: 2013
• 期刊: Journal of bacteriology
• 影响因子: 3.2
• 作者: Eddie,BrianJ;Hanson,ThomasE
• 通讯作者: Hanson,ThomasE