Neurogenic bladder dysfunctions in neurological disorders
神经系统疾病中的神经源性膀胱功能障碍
基本信息
- 批准号:8720934
- 负责人:
- 金额:$ 7.39万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-09-29 至 2014-07-31
- 项目状态:已结题
- 来源:
- 关键词:Adrenergic AgentsAdrenergic AgonistsAffectAfferent NeuronsAgonistAlzheimer&aposs DiseaseAmyotrophic Lateral SclerosisAnimal ModelAnimalsAreaBasic ScienceBehavioralBladderBladder DysfunctionBrainBrain StemCellsCellular biologyCentral Nervous System DiseasesClinicClinicalClinical SciencesConfocal MicroscopyDataDemyelinationsDevelopmentDiagnosisDiseaseDisease remissionEncephalomyelitisEtiologyEvaluationFilamentFlareFrequenciesFunctional disorderImage AnalysisImmunohistochemistryImpairmentIn VitroIncontinenceIncreased frequency of micturitionInterdisciplinary StudyLaboratoriesLesionLocationLower urinary tractMicrobiologyModelingMotorMultiple SclerosisMurine hepatitis virusMusMuscarinicsNatureNerve DegenerationNervous system structureNeural PathwaysNeuraxisNeurodegenerative DisordersNeurogenic BladderNeurologyNeuronsNeurosciencesNeurotransmitter ReceptorNocturiaOveractive BladderParkinson DiseasePathologyPathway interactionsPatientsPeripheralPharmacologyPhenotypePhiladelphiaPontine structureQuality ControlResearchResearch InfrastructureResearch PersonnelResearch Project GrantsSensorySeveritiesSmooth MuscleSpinal CordSpinal GangliaStreamSymptomsTechniquesTestingTissuesUnited StatesUrinationUrineUrologyVisceraladrenergicanimal tissueawakebasedisabilityfunctional disabilityfunctional statusin vivolower urinary tract symptomsmeetingsmicturition urgencymidbrain central gray substancemouse modelnervous system disorderneurophysiologyneuroregulationnovel therapeuticsprogramsreceptor internalizationresearch studyresponsetherapeutic developmenttranslational approachtreatment strategyurologicyoung adult
项目摘要
DESCRIPTION (provided by applicant): Patients with neurological disorders such as multiple sclerosis, Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis develop a wide range of lower urinary tract symptoms (LUTS) including urinary urgency, frequency, incontinence, nocturia. Neurogenic bladder dysfunctions observed in patients with neurological disorders usually result from damage to the peripheral and/or central nervous systems. The lack of understanding of pathophysiology and mechanisms underlying LUT dysfunctions in neurological disorders hampers the development of therapeutic strategies and treatment options for these patients. In response to the RFA-DK-12-003, we propose to form the Philadelphia Interdisciplinary Research Center on Neurogenic Bladder Dysfunctions. The primary focus of the Center will be on understanding the systemic and cellular mechanisms of neurogenic bladder dysfunctions resulting from degeneration in the CNS in order to clarify functional interplay between the urologic and nervous systems. The Philadelphia Center will: a) provide the intellectual infrastructure to tackle on projects that will become comprehensive programs determining the underlying etiology of LUTS in neurological disorders; b) establish a well-integrated interdisciplinary research team of clinical and basic science researchers in the Greater Philadelphia area which will focus the research efforts on LUTS using animal models of neurogenic bladder dysfunctions; c) extend the phenotyping of LUTS from animal models to patients diagnosed with neurological disorders and complaining of LUTS, and d) generate preliminary data necessary to submit a program project (POI) after completion of this study. The research team will include established investigators with diverse expertise in neurourology, neurophysiology, pharmacology, microbiology, neurodegeneration, and clinical neurology. The Philadelphia IR-BU Center W\\\ consist of: 1) the laboratories of key investigators and their collaborators that combine expertise in neurology, neurourology, neurophysiology, cellular biology, microbiology, neuroscience, pharmacology, and pathology; 2) an Administrative Core to provide administrative and fiscal oversight, quality control for the research, coordination of interactions among key investigators in the Center and organization of monthly meetings; 3) an Animal tissue core to provide tissues from mice with different levels of neurodegeneration and demyelination for basic research projects; 4) an Educational Enrichment Program to attract young investigators to the field of urology and support their research in the laboratories of key investigators.
描述(由申请人提供):患有神经系统疾病(例如多发性硬化症、帕金森病、阿尔茨海默病、肌萎缩侧索硬化症)的患者会出现多种下尿路症状(LUTS),包括尿急、尿频、尿失禁、夜尿。在患有神经系统疾病的患者中观察到的神经源性膀胱功能障碍通常是由于周围和/或中枢神经系统受损所致。对神经系统疾病中 LUT 功能障碍的病理生理学和机制缺乏了解,阻碍了针对这些患者的治疗策略和治疗方案的制定。为了响应 RFA-DK-12-003,我们提议成立费城神经源性膀胱功能障碍跨学科研究中心。该中心的主要重点是了解中枢神经系统退化引起的神经源性膀胱功能障碍的系统和细胞机制,以阐明泌尿系统和神经系统之间的功能相互作用。费城中心将: a) 提供知识基础设施来开展项目,这些项目将成为确定神经系统疾病中 LUTS 潜在病因的综合项目; b) 在大费城地区建立一个由临床和基础科学研究人员组成的综合性跨学科研究团队,重点研究使用神经源性膀胱功能障碍动物模型的 LUTS; c) 将 LUTS 表型分析从动物模型扩展到诊断为神经系统疾病并主诉 LUTS 的患者,以及 d) 生成完成本研究后提交计划项目 (POI) 所需的初步数据。该研究团队将包括在神经泌尿学、神经生理学、药理学、微生物学、神经退行性疾病和临床神经病学方面拥有不同专业知识的资深研究人员。费城 IR-BU 中心由以下组成: 1) 关键研究人员及其合作者的实验室,结合了神经学、神经泌尿学、神经生理学、细胞生物学、微生物学、神经科学、药理学和病理学方面的专业知识; 2) 行政核心,负责提供行政和财政监督、研究质量控制、中心主要研究人员之间的互动协调以及每月会议的组织; 3)动物组织核心,为基础研究项目提供不同程度神经变性和脱髓鞘小鼠的组织; 4) 教育丰富计划,吸引年轻研究人员进入泌尿外科领域并支持他们在关键研究人员实验室的研究。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Anna P Malykhina其他文献
PD70-03 FRESHLY DISSOCIATED SMOOTH MUSCLE CELLS FROM DETRUSOR OVERACTIVE HUMAN BLADDERS SHOW ABNORMAL EXPRESSION OF TREK-1 CHANNELS AND CAVEOLAE MEMBRANE MICRODOMAINS.
- DOI:
10.1016/j.juro.2017.02.3157 - 发表时间:
2017-04-01 - 期刊:
- 影响因子:
- 作者:
Ricardo Pineda;Balachandar Nedumaran;Joseph Hypolite;Shandra Wilson;Randall B Meachan;Anna P Malykhina - 通讯作者:
Anna P Malykhina
MP38-09 THE LACK OF MECHANOSENSITIVE K2P CHANNEL IS ASSOCIATED WITH MIXED VOIDING PHENOTYPE IN MICE
- DOI:
10.1016/j.juro.2018.02.1236 - 发表时间:
2018-04-01 - 期刊:
- 影响因子:
- 作者:
Ricardo Pineda;Joseph Hypolite;Sanghee Lee;Alonso Carrasco;Nao Iguchi;Randall B Meacham;Anna P Malykhina - 通讯作者:
Anna P Malykhina
THE ROLE OF SENSORY PATHWAYS IN THE DEVELOPMENT OF CROSS-SENSITIZATION BETWEEN THE URINARY AND GASTROINTESTINAL SYSTEMS
- DOI:
10.1016/s0022-5347(09)60956-3 - 发表时间:
2009-04-01 - 期刊:
- 影响因子:
- 作者:
Anna P Malykhina;Jessica A Gonzalez - 通讯作者:
Jessica A Gonzalez
Anna P Malykhina的其他文献
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{{ truncateString('Anna P Malykhina', 18)}}的其他基金
Mechanisms of neurogenic bladder dysfunction in a viral murine model of multiple sclerosis
多发性硬化症病毒小鼠模型中神经源性膀胱功能障碍的机制
- 批准号:
10256804 - 财政年份:2020
- 资助金额:
$ 7.39万 - 项目类别:
Mechanisms of neurogenic bladder dysfunction in a viral murine model of multiple sclerosis
多发性硬化症病毒小鼠模型中神经源性膀胱功能障碍的机制
- 批准号:
10450102 - 财政年份:2020
- 资助金额:
$ 7.39万 - 项目类别:
Mechanisms of neurogenic bladder dysfunction in a viral murine model of multiple sclerosis
多发性硬化症病毒小鼠模型中神经源性膀胱功能障碍的机制
- 批准号:
10047119 - 财政年份:2020
- 资助金额:
$ 7.39万 - 项目类别:
Regulation of pelvic pain and micturition reflex by VEGF in urological chronic pelvic pain syndrome
VEGF对泌尿科慢性盆腔疼痛综合征盆腔疼痛和排尿反射的调节作用
- 批准号:
9763111 - 财政年份:2019
- 资助金额:
$ 7.39万 - 项目类别:
Regulation of pelvic pain and micturition reflex by VEGF in urological chronic pelvic pain syndrome
VEGF对泌尿科慢性盆腔疼痛综合征盆腔疼痛和排尿反射的调节作用
- 批准号:
10166603 - 财政年份:2019
- 资助金额:
$ 7.39万 - 项目类别:
Role of Mechanotransduction in detrusor over activity
机械转导在逼尿肌过度活动中的作用
- 批准号:
8923257 - 财政年份:2014
- 资助金额:
$ 7.39万 - 项目类别:
Role of Mechanotransduction in detrusor over activity
机械转导在逼尿肌过度活动中的作用
- 批准号:
8695744 - 财政年份:2014
- 资助金额:
$ 7.39万 - 项目类别:
Role of Mechanotransduction in detrusor over activity
机械转导在逼尿肌过度活动中的作用
- 批准号:
9104155 - 财政年份:2014
- 资助金额:
$ 7.39万 - 项目类别:
Neurogenic bladder dysfunctions in neurological disorders
神经系统疾病中的神经源性膀胱功能障碍
- 批准号:
8566213 - 财政年份:2012
- 资助金额:
$ 7.39万 - 项目类别:
Neurogenic bladder dysfunctions in neurological disorders
神经系统疾病中的神经源性膀胱功能障碍
- 批准号:
8549236 - 财政年份:2012
- 资助金额:
$ 7.39万 - 项目类别:
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