Neurogenic bladder dysfunctions in neurological disorders

描述（由申请人提供）：神经系统疾病患者，如多发性硬化症，帕金森病，阿尔茨海默病，肌萎缩侧索硬化症，发展广泛的下尿路症状（LUTS），包括尿急，尿频，尿失禁，夜尿症。在神经系统疾病患者中观察到的神经源性膀胱功能障碍通常是由周围和/或中枢神经系统损伤引起的。缺乏对神经系统疾病中LUT功能障碍的病理生理学和机制的理解，阻碍了这些患者的治疗策略和治疗选择的发展。根据RFA-DK-12-003，我们建议成立费城神经源性膀胱功能障碍跨学科研究中心。该中心的主要重点将是了解由中枢神经系统变性引起的神经源性膀胱功能障碍的系统和细胞机制，以阐明泌尿系统和神经系统之间的功能相互作用。费城中心将：a)提供智力基础设施，以解决将成为确定神经系统疾病中LUTS的潜在病因的综合项目；b)在大费城地区建立一个由临床和基础科学研究人员组成的跨学科研究团队，将重点研究利用神经源性膀胱功能障碍动物模型的LUTS；c)将LUTS的表型从动物模型扩展到诊断为神经系统疾病并有LUTS主诉的患者，d)生成必要的初步数据，以便在本研究完成后提交项目（POI）。研究团队将包括在神经学、神经生理学、药理学、微生物学、神经变性和临床神经学方面具有不同专业知识的知名研究人员。费城IR-BU中心包括：1)重点研究人员及其合作者的实验室，他们结合了神经病学、神经病学、神经生理学、细胞生物学、微生物学、神经科学、药理学和病理学方面的专业知识；2)设立行政核心，提供行政和财政监督、研究质量控制、协调中心主要研究人员之间的互动以及组织月度会议；3)动物组织核，为基础研究项目提供不同程度的神经变性和脱髓鞘小鼠组织；4)教育充实计划，吸引年轻的研究人员进入泌尿外科领域，并支持他们在重点研究人员的实验室进行研究。

DESCRIPTION (provided by applicant): Patients with neurological disorders such as multiple sclerosis, Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis develop a wide range of lower urinary tract symptoms (LUTS) including urinary urgency, frequency, incontinence, nocturia. Neurogenic bladder dysfunctions observed in patients with neurological disorders usually result from damage to the peripheral and/or central nervous systems. The lack of understanding of pathophysiology and mechanisms underlying LUT dysfunctions in neurological disorders hampers the development of therapeutic strategies and treatment options for these patients. In response to the RFA-DK-12-003, we propose to form the Philadelphia Interdisciplinary Research Center on Neurogenic Bladder Dysfunctions. The primary focus of the Center will be on understanding the systemic and cellular mechanisms of neurogenic bladder dysfunctions resulting from degeneration in the CNS in order to clarify functional interplay between the urologic and nervous systems. The Philadelphia Center will: a) provide the intellectual infrastructure to tackle on projects that will become comprehensive programs determining the underlying etiology of LUTS in neurological disorders; b) establish a well-integrated interdisciplinary research team of clinical and basic science researchers in the Greater Philadelphia area which will focus the research efforts on LUTS using animal models of neurogenic bladder dysfunctions; c) extend the phenotyping of LUTS from animal models to patients diagnosed with neurological disorders and complaining of LUTS, and d) generate preliminary data necessary to submit a program project (POI) after completion of this study. The research team will include established investigators with diverse expertise in neurourology, neurophysiology, pharmacology, microbiology, neurodegeneration, and clinical neurology. The Philadelphia IR-BU Center W\\\ consist of: 1) the laboratories of key investigators and their collaborators that combine expertise in neurology, neurourology, neurophysiology, cellular biology, microbiology, neuroscience, pharmacology, and pathology; 2) an Administrative Core to provide administrative and fiscal oversight, quality control for the research, coordination of interactions among key investigators in the Center and organization of monthly meetings; 3) an Animal tissue core to provide tissues from mice with different levels of neurodegeneration and demyelination for basic research projects; 4) an Educational Enrichment Program to attract young investigators to the field of urology and support their research in the laboratories of key investigators.