Tissue Procurement Core

组织采购核心

• 批准号: 8550023
• 负责人: DOMENICO COPPOLA
• 金额: $ 8.67万
• 依托单位: H. LEE MOFFITT CANCER CTR & RES INST
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8550023
• 关键词: Affect; Basic Science; Biocompatible Materials; Biological; Biological Markers; Blood; Cancer Center; Collection; DNA; Development; Diagnostic; Environment; Epigenetic Process; Florida; Fresh Tissue; Future; Genes; Genetic; Genomics; Hispanics; Histological Techniques; Human; Immunohistochemistry; Individual; Institution; Institutional Review Boards; Island; Life; Malignant Neoplasms; Medicine; Methods; Mexican Americans; MicroRNAs; Minority; Molecular; Paraffin; Patients; Pharmacogenomics; Population; Predisposing Factor; Preparation; Prevalence; Procedures; Process; Proteomics; Public Health; Puerto Rican; Puerto Rico; RNA; Research; Research Infrastructure; Research Personnel; Research Support; Resources; Sampling; Serum; Single Nucleotide Polymorphism; Solid; Technology; Tissue Banking; Tissue Banks; Tissue Microarray; Tissue Procurements; Tissues; Tumor Tissue; anticancer research; base; cancer health disparity; cancer type; medical schools; prognostic; protein expression; repository; response; trend

The purpose of the TPC at Ponce School of Medicine (PSM) is to facilitate the collection, processing, and storage of well-annotated human biospeclmens for use in investigator-initiated translational cancer research. Throughout the past five years a solid infrastructure was put in place to develop the first tumor tissue bank In Puerto Rico, capable of the optimal collection, processing, and distribution of biological materials derived from the island's Hispanic population. Through this unique resource, which follows the same standard operational procedures (SOPs) established at the Tissue Core at MCC (and which are I approved by our institutions' IRB committees), fresh tissues and high quality RNA are already available to | support research at both institutions focusing on the molecular aspects and biological determinants of cancer health disparities involving Puerto Rican Hispanics living in Puerto Rico and Hispanics living in Florida. This facility is a valuable resource of high public health significance given that 1) Hispanics represent 15% of the US population (the fastest growing minority population), 2) most cancer health-disparity studies in the US have been conducted with Mexican-American populations, 3) there are differences in cancer trends and unique aspects associated to cancer health disparities among the different Hispanic populations, and 4) there is a scarcity of basic science-oriented cancer studies involving Puerto Ricans. Availability of biospeclmens (normal/tumor tissue, serum/DNA) from this population will support much needed research on cancer health disparities and facilitate answering questions on gene-environment-culture interactions involving Hispanics.

TPC在医学（PSM）的庞塞学校的目的是为了方便收集，处理， 储存注释良好的人类生物样品，用于化学家发起的转化癌症研究。 在过去的五年里，建立了一个坚实的基础设施，以开发第一个肿瘤组织。 银行在波多黎各，能够最佳的收集，处理和分配生物 来自岛上西班牙裔人口的材料。通过这个独特的资源，它遵循 在MCC的组织中心建立的相同标准操作规程（SOP）（其中I 经我们机构的IRB委员会批准），新鲜组织和高质量RNA已经可用于| 支持这两个机构的研究，重点是癌症的分子方面和生物决定因素 生活在波多黎各的波多黎各西班牙裔人和生活在佛罗里达的西班牙裔人的健康差距。这 设施是一种具有高度公共卫生意义的宝贵资源，因为1）西班牙裔占美国人口的15% 人口（增长最快的少数民族人口），2）美国大多数癌症健康差异研究 在墨西哥裔美国人中进行，3）癌症趋势存在差异， 与不同西班牙裔人群之间癌症健康差异相关的方面，以及4）有一个 缺乏涉及波多黎各人的基础科学导向的癌症研究。生物样品的可得性 （正常/肿瘤组织，血清/DNA）将支持急需的癌症健康研究 差异和促进回答问题的基因，环境，文化的相互作用，涉及西班牙裔。