Tissue Procurement Core

庞塞医学院(PSM)的TPC的目的是促进收集、处理和 用于研究人员发起的转化型癌症研究的注释良好的人类生物谱系的存储。 在过去的五年里，建立了坚实的基础设施来开发第一个肿瘤组织 波多黎各银行，能够最佳地收集、处理和分发生物 材料来自岛上的西班牙裔人口。通过这个唯一的资源，它遵循 在MCC的组织核心建立的相同标准操作程序(SOP)(哪些是I 经我们院校的IRB委员会批准)，新鲜的组织和高质量的RNA已经可以提供给... 支持这两个机构侧重于癌症的分子方面和生物决定因素的研究 居住在波多黎各的波多黎各西语裔和生活在佛罗里达的西语裔之间的健康差距。这 鉴于拉美裔占美国人口的15%，设施是一项具有高度公共卫生意义的宝贵资源 人口(增长最快的少数族裔人口)，2)美国大多数癌症健康差异研究 在墨西哥裔美国人中进行了调查，3)癌症的趋势和独特性存在差异 与不同拉美裔人群之间的癌症健康差异有关的方面，以及4)存在 缺乏涉及波多黎各人的以基础科学为导向的癌症研究。生物谱系的可利用性 (正常/肿瘤组织、血清/DNA)这一人群将支持急需的癌症健康研究 这将有助于回答涉及拉美裔美国人的基因-环境-文化互动方面的问题。

The purpose of the TPC at Ponce School of Medicine (PSM) is to facilitate the collection, processing, and storage of well-annotated human biospeclmens for use in investigator-initiated translational cancer research. Throughout the past five years a solid infrastructure was put in place to develop the first tumor tissue bank In Puerto Rico, capable of the optimal collection, processing, and distribution of biological materials derived from the island's Hispanic population. Through this unique resource, which follows the same standard operational procedures (SOPs) established at the Tissue Core at MCC (and which are I approved by our institutions' IRB committees), fresh tissues and high quality RNA are already available to | support research at both institutions focusing on the molecular aspects and biological determinants of cancer health disparities involving Puerto Rican Hispanics living in Puerto Rico and Hispanics living in Florida. This facility is a valuable resource of high public health significance given that 1) Hispanics represent 15% of the US population (the fastest growing minority population), 2) most cancer health-disparity studies in the US have been conducted with Mexican-American populations, 3) there are differences in cancer trends and unique aspects associated to cancer health disparities among the different Hispanic populations, and 4) there is a scarcity of basic science-oriented cancer studies involving Puerto Ricans. Availability of biospeclmens (normal/tumor tissue, serum/DNA) from this population will support much needed research on cancer health disparities and facilitate answering questions on gene-environment-culture interactions involving Hispanics.