DATA MANAGEMENT AND RESOURCE REPOSITORY FOR THE exRNA ATLAS

exRNA 图谱的数据管理和资源库

• 批准号: 8583539
• 负责人: DAVID J. GALAS
• 金额: $ 242.4万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8583539
• 关键词: Architecture; Atlases; Biological; Biology; Blood Circulation; Body Fluids; Cells; Collection; Communication; Communication Programs; Communities; Data; Data Analyses; Databases; Edible Plants; Educational workshop; Encapsulated; Endocrine system; Ensure; Genes; Genomics; Human; Human body; Imagery; Individual; Information Resources Management; Internet; Knowledge; Lead; Link; Malignant Neoplasms; Metadata; Metagenomics; Methods; Microbe; Modeling; Nervous system structure; Participant; Pathway interactions; Process; Protocols documentation; RNA; Research; Resource Development; Resources; Role; Site; System; Technology; base; cell type; data integration; data management; data mining; distributed data; extracellular; human disease; intercellular communication; knowledge base; outreach; public health relevance; repository; symposium; tool; uptake; wiki

DESCRIPTION (provided by applicant): Extra-cellular RNAs (exRNAs) are emitted into the human bloodstream and other body fluids by different types of cells in the human body and may be uptaken by other cells. The exRNAs may also originate from edible plants and from microbes that inhabit the human body. The Extracellular RNA Communication Program (ERCP) will explore this newly discovered mechanism of communication in healthy individuals and in pathological conditions such as cancer. The Data Management Resource and Repository for the exRNA Atlas (DMRR) will integrate the efforts of the FRCP and serve as a community-wide resource for the development of the exRNA Atlas database. DMRR will consist of three components and an Administrative Core. The Data Coordination Component (DCC) will develop data and metadata standards, establish data flow into the exRNA Atlas database; develop tools for download, visualization and analysis of exRNA data; and integrate exRNA Atlas database with other relevant resources. The Scientific Outreach Component (SOC) will develop the exRNA Atlas Web Portal to disseminate and provide for visualization of the exRNA Atlas data; ensure accessibility of ERCP-generated resources; and initiate community engagement in exRNA biology using leading biological Wiki sites. In close coordination with the DCC, the SOC will engage the community through knowledge curation jamborees, scientific workshops and symposia. The Data Integration and Analysis Component (DIAC) will provide large-scale integrative and analytic support; evaluate tools and build pipelines to be hosted by DCC and used to populate the exRNA Atlas; build tools to be deployed and distributed by the DCC for use by other consortium participants and the wider scientific community for exRNA data; and lead consortium-wide advanced integrative analyses. Through these coordinated efforts of its DCC, SOC, and DIAC components, the DMRR will help organize the ERCP consortium and open opportunities for rapid progress in the nascent field of exRNA biology.

描述（由申请人提供）：细胞外RNA（exRNA）由人体中不同类型的细胞释放到人体血流和其他体液中，并可被其他细胞摄取。exRNA也可以来源于可食用植物和栖息在人体内的微生物。细胞外RNA通讯计划（ERCP）将探索这种新发现的健康个体和癌症等病理条件下的通讯机制。exRNA图谱的数据管理资源和储存库（DMRR）将整合FRCP的工作，并作为开发exRNA图谱数据库的社区资源。DMRR将由三个部分和一个行政核心组成。数据协调部分将制定数据和元数据标准，建立进入exRNA Atlas数据库的数据流;开发下载、可视化和分析exRNA数据的工具;并将exRNA Atlas数据库与其他相关资源整合。科学外联部分将开发exRNA图谱门户网站，以传播exRNA图谱数据并提供其可视化;确保可获得ERCP生成的资源;并利用主要的生物维基网站启动社区参与exRNA生物学。SOC将与DCC密切协调，通过知识策展大会、科学研讨会和专题讨论会吸引社区参与。数据集成和分析组件（DIAC）将提供大规模的综合和分析支持;评估工具并建立管道，由DCC托管并用于填充exRNA图谱;建立由DCC部署和分发的工具，供其他联盟参与者和更广泛的科学界使用exRNA数据;并领导联盟范围内的高级综合分析。通过其DCC、SOC和DIAC组成部分的协调努力，DMRR将有助于组织ERCP联盟，并为exRNA生物学的新生领域的快速进展创造机会。