DATA MANAGEMENT AND RESOURCE REPOSITORY FOR THE exRNA ATLAS

描述(申请人提供)：细胞外RNA(ExRNAs)由人体内不同类型的细胞释放到人体血液和其他体液中，并可能被其他细胞摄取。ExRNAs也可能来自可食用植物和居住在人体内的微生物。细胞外RNA通讯计划(ERCP)将探索这种新发现的在健康个体和癌症等病理条件下的通讯机制。外源核糖核酸图谱数据管理资源和储存库(DMRR)将整合外源核糖核酸图谱数据管理中心的工作，作为开发外源核糖核酸图谱数据库的全社区资源。DMRR将由三个组成部分和一个管理核心组成。数据协调部分将制定数据和元数据标准，建立流入外源核糖核酸图谱数据库的数据流；开发外源核糖核酸数据下载、可视化和分析工具；将外源核糖核酸图谱数据库与其他相关资源结合起来。科学外联部分(SOC)将开发外源核糖核酸图谱网络门户，以传播外源核糖核酸图谱数据并提供可视化；确保可获得由外源核糖核酸计划生成的资源；并利用领先的生物维基网站发起社区参与外源核糖核酸生物学研究。在与DCC的密切协调下，SOC将通过知识策划活动、科学研讨会和研讨会让社区参与进来。数据集成和分析部分(DIAC)将提供大规模的综合和分析支持；评价将由DCC托管并用于填充exRNA地图集的工具和管道；建立将由DCC部署和分发的工具，供其他联合体参与者和更广泛的科学界用于exRNA数据；领导整个联合体的高级综合分析。通过其DCC、SOC和DIAC组件的这些协调努力，DMRR将帮助组织ERCP联盟，并为新生的exRNA生物学领域的快速发展打开机会。

DESCRIPTION (provided by applicant): Extra-cellular RNAs (exRNAs) are emitted into the human bloodstream and other body fluids by different types of cells in the human body and may be uptaken by other cells. The exRNAs may also originate from edible plants and from microbes that inhabit the human body. The Extracellular RNA Communication Program (ERCP) will explore this newly discovered mechanism of communication in healthy individuals and in pathological conditions such as cancer. The Data Management Resource and Repository for the exRNA Atlas (DMRR) will integrate the efforts of the FRCP and serve as a community-wide resource for the development of the exRNA Atlas database. DMRR will consist of three components and an Administrative Core. The Data Coordination Component (DCC) will develop data and metadata standards, establish data flow into the exRNA Atlas database; develop tools for download, visualization and analysis of exRNA data; and integrate exRNA Atlas database with other relevant resources. The Scientific Outreach Component (SOC) will develop the exRNA Atlas Web Portal to disseminate and provide for visualization of the exRNA Atlas data; ensure accessibility of ERCP-generated resources; and initiate community engagement in exRNA biology using leading biological Wiki sites. In close coordination with the DCC, the SOC will engage the community through knowledge curation jamborees, scientific workshops and symposia. The Data Integration and Analysis Component (DIAC) will provide large-scale integrative and analytic support; evaluate tools and build pipelines to be hosted by DCC and used to populate the exRNA Atlas; build tools to be deployed and distributed by the DCC for use by other consortium participants and the wider scientific community for exRNA data; and lead consortium-wide advanced integrative analyses. Through these coordinated efforts of its DCC, SOC, and DIAC components, the DMRR will help organize the ERCP consortium and open opportunities for rapid progress in the nascent field of exRNA biology.