Combined RCM and PSOCT for skin cancer imaging

结合 RCM 和 PSOCT 进行皮肤癌成像

• 批准号: 8534059
• 负责人: Mircea Mujat
• 金额: $ 12.38万
• 依托单位: PHYSICAL SCIENCES, INC
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8534059
• 关键词: Algorithms; Am 80; Basal cell carcinoma; Benign; Biological; Biopsy; Birefringence; Cancer Patient; Clinical; Collaborations; Confocal Microscopy; Dermal; Dermatologist; Dermatology; Dermis; Dermoscopy; Detection; Devices; Diagnosis; Diagnostic; Diagnostic Neoplasm Staging; Emotional; Engineering; Epidermis; Face; Feedback; Head; Health Care Costs; Healthcare Systems; Human; Image; Imaging technology; Invaded; Investigation; Lateral; Lesion; Malignant Neoplasms; Marketing; Measures; Memorial Sloan-Kettering Cancer Center; Methods; Microscope; Modality; Mohs Surgery; Morphology; Nuclear; Operative Surgical Procedures; Optical Coherence Tomography; Optics; Papillary; Pathologist; Pathology; Patients; Performance; Phase; Pigments; Pilot Projects; Property; Relative (related person); Reporting; Research; Resolution; Sensitivity and Specificity; Skin; Skin Cancer; Specificity; Specimen; Squamous cell carcinoma; Staging; Staining method; Stains; System; Technology; Testing; Time; Tissues; Training; Validation; Visual; base; cancer diagnosis; cancer imaging; cancer site; cost; design; experience; imaging Segmentation; improved; in vivo; instrument; melanoma; novel; optical imaging; phase 2 study; physical science; programs; prototype; screening; skin lesion; success; treatment planning; tv watching; volunteer

DESCRIPTION (provided by applicant): Physical Sciences, Inc. (PSI), in collaboration with Memorial Sloan Kettering Cancer Center (MSKCC) and Lucid, Inc., proposes to investigate the use of combined reflectance confocal microscopy- polarization sensitive optical coherence tomography (RCM-PSOCT) for in vivo diagnosis of skin cancers. Both RCM and OCT are powerful technologies with proven success in human skin imaging. While RCM provides en face images with nuclear-level resolution in superficial skin, to depths of about 200 mm, OCT provides cross-sectional images with structural-level resolution in the deeper skin layers, to depths of at least 1 mm. Furthermore, PSOCT measures skin birefringence, and thus accurately differentiates between the dermal and epidermal skin layers. Therefore, the complementary capabilities of these two optical technologies may be exploited to offer a clinically comprehensive set of parameters for diagnostics which neither modality can provide by itself: presence and lateral spread of cancer, location of the dermo- epidermal junction and depth (stage) of invasion. Thus, this technology could help clinicians to provide more reliable diagnosis of suspicious skin lesions and significantly reduce the number of unnecessary biopsies. For a preliminary investigation of this powerful dual-mode imaging approach, a novel method for automated localization of the dermo-epidermal (DE) junction is proposed. In Phase I we propose to develop a benchtop instrument that will combine RCM and PSOCT within the same optical layout. Preliminary testing of this instrument will be performed on excised tissue specimens and on the normal skin of several volunteers. Based on Phase I conclusions, this instrument will be improved and a clinical prototype will be built and tested in a clinical setting on a larger number of normal and skin cancer patients during the Phase II study.

描述（由申请人提供）：Physical Sciences，Inc. (PSI)与纪念斯隆凯特琳癌症中心（MSKCC）和Lucid公司合作，提出研究使用组合反射共焦显微镜-偏振敏感光学相干断层扫描（RCM-PSOCT）在体内诊断皮肤癌。RCM和OCT都是功能强大的技术，在人体皮肤成像方面取得了成功。虽然RCM在表层皮肤中提供具有核级分辨率的面部图像，深度约为200 mm，但OCT在深层皮肤中提供具有结构级分辨率的横截面图像，深度至少为1 mm。此外，PSOCT测量皮肤双折射，从而准确区分真皮和表皮皮肤层。因此，可以利用这两种光学技术的互补能力来提供用于诊断的一组临床综合参数，这两种模式本身都不能提供：癌症的存在和侧向扩散、真皮-表皮接合部的位置和侵入的深度（阶段）。因此，这项技术可以帮助临床医生对可疑皮肤病变提供更可靠的诊断，并显着减少不必要的活检次数。对于这种强大的双模式成像方法的初步调查，提出了一种新的自动定位的真皮表皮（DE）交界处的方法。在第一阶段，我们建议开发一个台式仪器，将联合收割机RCM和PSOCT在相同的光学布局。将在切除的组织标本和几名志愿者的正常皮肤上对该仪器进行初步测试。根据I期结论，将对该仪器进行改进，并在II期研究期间在临床环境中对大量正常和皮肤癌患者建立和测试临床原型。