Versatile Eye Tracking for Improved High-resolution Retinal Imaging

多功能眼动追踪可改善高分辨率视网膜成像

• 批准号: 10154113
• 负责人: Mircea Mujat
• 金额: $ 25.84万
• 依托单位: PHYSICAL SCIENCES, INC
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10154113
• 关键词: Address; Affect; Algorithms; Area; Attenuated; Characteristics; Clinic; Clinical; Computer software; Computers; Cone; Confocal Microscopy; Custom; Data Set; Development; Device or Instrument Development; Devices; Diagnostic; Disease; Disease Progression; Early Diagnosis; Endoscopy; Evaluation; Eye; Eye Movements; Frequencies; Government; Health Personnel; Human; Human Volunteers; Image; Imaging Techniques; Imaging technology; Individual; Industry; Institutional Review Boards; Lasers; Letters; Measurement; Measures; Methods; Modeling; Modern Medicine; Modification; Monitor; Morphologic artifacts; Motion; New England; Operative Surgical Procedures; Ophthalmoscopy; Optical Coherence Tomography; Optics; Patients; Persons; Phase; Photoreceptors; Play; Procedures; Protocols documentation; Psychophysics; Publishing; Research; Research Personnel; Resolution; Retina; Robotics; Scanning; Signal Transduction; Speed; Stimulus; Structure; System; Techniques; Technology; Testing; Time; Vision; adaptive optics; adaptive optics scanning laser ophthalmoscopy; base; clinical application; computer game; computer science; cost effective; data exchange; experimental study; falls; ganglion cell; high resolution imaging; image registration; imager; imaging modality; imaging platform; improved; lens; movie; multimodality; novel strategies; physical science; programs; real-time images; research clinical testing; response; retinal imaging; sample fixation; success; tool; treatment response; vision science; visual stimulus; visual tracking; volunteer

Project Summary/Abstract Physical Sciences Inc (PSI) proposes to develop a robust eye tracking technology to enhance the quality of high-resolution retinal imaging videos by significantly reducing the image artifacts induced by involuntary eye motion. The living human eye is constantly moving. A constant visual stimulus can make the photoreceptors or the ganglion cells (GC) become unresponsive. The eye movement constantly changes the stimuli that fall on the cones/GC’s, making the image clearer. However, eye motion has deleterious effects in retinal imaging and image stabilization is needed to attenuate these effects. Adaptive optics (AO) systems are being extended to precision stimulus delivery, microperimetry, measurement of intrinsic retinal signals, psychophysics, and structural and functional vision studies in the research lab and the clinic. The multi-channel AO retinal imager (MAORI) developed by PSI is a new tool for researchers and clinicians to investigate and monitor changes of retinal microstructures due to disease progression or response to treatment. However, one of the main challenges for routine clinical application of high- resolution retinal imaging remains eye motion. We propose to use retinal tracking to improve the efficiency of an imaging session by significantly reducing the number of uncorrectable images in each data set, and therefore by minimizing the time that both the patient and the medical personnel spend imaging. PSI will build on our expertise in eye tracking and high-resolution retinal imaging and leverage recent advances in real-time video image stabilization developed in vision and computer science. PSI will develop a plug-and- play solution that can be adapted to any imaging platform that requires image stabilization. A stand-alone device that can be incorporated with minimal modifications into existing platforms will help transfer high- resolution retinal imaging from research labs into routine clinical applications.

项目概要/摘要 物理科学公司（PSI）提议开发一种强大的眼动追踪技术来增强 通过显着减少由以下因素引起的图像伪影，提高高分辨率视网膜成像视频的质量 不自觉的眼球运动。活生生的人眼在不断地移动。持续的视觉刺激可以使 光感受器或神经节细胞 (GC) 变得无反应。眼球不断转动 改变落在视锥细胞/GC 上的刺激，使图像更清晰。然而，眼球运动有 需要对视网膜成像和图像稳定产生有害影响来减弱这些影响。自适应 光学 (AO) 系统正在扩展到精确刺激传递、显微视野测量、 研究实验室中的内在视网膜信号、心理物理学以及结构和功能视觉研究 诊所。 PSI开发的多通道AO视网膜成像仪（MAORI）是研究人员的新工具 和临床医生调查和监测由于疾病进展或疾病引起的视网膜微结构的变化 对治疗的反应。然而，常规临床应用的主要挑战之一 视网膜成像的分辨率仍然是眼球运动。我们建议使用视网膜跟踪来提高效率 通过显着减少每个数据集中不可校正图像的数量来减少成像会话的影响，以及 因此，通过最大限度地减少患者和医务人员花费在成像上的时间。 PSI 将 以我们在眼动追踪和高分辨率视网膜成像方面的专业知识为基础，并利用最新的进展 视觉和计算机科学领域开发的实时视频图像稳定。 PSI 将开发一种即插即用的 播放解决方案，可适应任何需要图像稳定的成像平台。一个独立的 可以通过最少的修改整合到现有平台中的设备将有助于传输高 分辨率视网膜成像从研究实验室到常规临床应用。