Versatile Eye Tracking for Improved High-resolution Retinal Imaging

多功能眼动追踪可改善高分辨率视网膜成像

• 批准号: 10154113
• 负责人: Mircea Mujat
• 金额: $ 25.84万
• 依托单位: PHYSICAL SCIENCES, INC
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10154113
• 关键词: Address; Affect; Algorithms; Area; Attenuated; Characteristics; Clinic; Clinical; Computer software; Computers; Cone; Confocal Microscopy; Custom; Data Set; Development; Device or Instrument Development; Devices; Diagnostic; Disease; Disease Progression; Early Diagnosis; Endoscopy; Evaluation; Eye; Eye Movements; Frequencies; Government; Health Personnel; Human; Human Volunteers; Image; Imaging Techniques; Imaging technology; Individual; Industry; Institutional Review Boards; Lasers; Letters; Measurement; Measures; Methods; Modeling; Modern Medicine; Modification; Monitor; Morphologic artifacts; Motion; New England; Operative Surgical Procedures; Ophthalmoscopy; Optical Coherence Tomography; Optics; Patients; Persons; Phase; Photoreceptors; Play; Procedures; Protocols documentation; Psychophysics; Publishing; Research; Research Personnel; Resolution; Retina; Robotics; Scanning; Signal Transduction; Speed; Stimulus; Structure; System; Techniques; Technology; Testing; Time; Vision; adaptive optics; adaptive optics scanning laser ophthalmoscopy; base; clinical application; computer game; computer science; cost effective; data exchange; experimental study; falls; ganglion cell; high resolution imaging; image registration; imager; imaging modality; imaging platform; improved; lens; movie; multimodality; novel strategies; physical science; programs; real-time images; research clinical testing; response; retinal imaging; sample fixation; success; tool; treatment response; vision science; visual stimulus; visual tracking; volunteer

Project Summary/Abstract Physical Sciences Inc (PSI) proposes to develop a robust eye tracking technology to enhance the quality of high-resolution retinal imaging videos by significantly reducing the image artifacts induced by involuntary eye motion. The living human eye is constantly moving. A constant visual stimulus can make the photoreceptors or the ganglion cells (GC) become unresponsive. The eye movement constantly changes the stimuli that fall on the cones/GC’s, making the image clearer. However, eye motion has deleterious effects in retinal imaging and image stabilization is needed to attenuate these effects. Adaptive optics (AO) systems are being extended to precision stimulus delivery, microperimetry, measurement of intrinsic retinal signals, psychophysics, and structural and functional vision studies in the research lab and the clinic. The multi-channel AO retinal imager (MAORI) developed by PSI is a new tool for researchers and clinicians to investigate and monitor changes of retinal microstructures due to disease progression or response to treatment. However, one of the main challenges for routine clinical application of high- resolution retinal imaging remains eye motion. We propose to use retinal tracking to improve the efficiency of an imaging session by significantly reducing the number of uncorrectable images in each data set, and therefore by minimizing the time that both the patient and the medical personnel spend imaging. PSI will build on our expertise in eye tracking and high-resolution retinal imaging and leverage recent advances in real-time video image stabilization developed in vision and computer science. PSI will develop a plug-and- play solution that can be adapted to any imaging platform that requires image stabilization. A stand-alone device that can be incorporated with minimal modifications into existing platforms will help transfer high- resolution retinal imaging from research labs into routine clinical applications.

项目总结/摘要 物理科学公司（PSI）提出开发一种强大的眼动跟踪技术，以提高 高分辨率视网膜成像视频的质量，通过显着减少图像伪影引起的 无意识眼球运动人的眼睛是不断移动的。持续的视觉刺激可以使 光感受器或神经节细胞（GC）变得无反应。眼球运动不断 改变落在视锥细胞/GC上的刺激，使图像更清晰。然而，眼球运动 需要视网膜成像和图像稳定中的有害影响来减弱这些影响。自适应 光学（AO）系统正被扩展到精确的刺激递送、微视野计、 内在的视网膜信号，心理物理学，结构和功能的视觉研究在研究实验室和 诊所PSI研制的多通道AO视网膜成像仪（MAORI）是研究人员的一种新工具 和临床医生研究和监测由于疾病进展引起的视网膜微观结构的变化， 对治疗反应。然而，常规临床应用的主要挑战之一是高- 分辨率视网膜成像保持眼睛运动。我们建议使用视网膜跟踪来提高效率 通过显著减少每个数据集中不可校正图像的数量， 因此，通过最大限度地减少患者和医务人员花费成像的时间。PSI将 基于我们在眼动追踪和高分辨率视网膜成像方面的专业知识， 在视觉和计算机科学中发展起来的实时视频图像稳定。PSI将开发一个插件- Play解决方案，可适用于任何需要图像稳定的成像平台。独立 一种可以在对现有平台进行最小修改的情况下集成的装置将有助于将高能量 高分辨率视网膜成像从研究实验室到常规临床应用。