Versatile Eye Tracking for Improved High-resolution Retinal Imaging

项目摘要/摘要 物理科学公司(PSI)建议开发一种强大的眼睛跟踪技术，以增强 通过显著减少以下引起的图像伪影来提高高分辨率视网膜成像视频的质量 不由自主的眼球运动。活着的人的眼睛在不停地移动。持续的视觉刺激可以使 感光细胞或神经节细胞(GC)变得无反应。眼球不停地运动 更改落在锥体/GC上的刺激，使图像更清晰。然而，眼球运动有 视网膜成像中的有害影响和图像稳定是需要减弱这些影响的。适应性 光学(AO)系统正在扩展到精确的刺激传递、微视野、测量 研究实验室中的固有视网膜信号、心理物理学以及结构和功能视觉研究 诊所。PSI公司开发的多通道光学视网膜成像仪(MAORI)是研究人员的一种新工具 和临床医生调查和监测因疾病进展或疾病进展而引起的视网膜微结构变化 对治疗的反应。然而，高密度脂蛋白常规临床应用的主要挑战之一是 分辨率视网膜成像保持眼球运动。我们建议使用视网膜跟踪来提高效率 通过显著减少每个数据集中的不可校正图像的数量，以及 因此，通过最小化患者和医务人员花费在成像上的时间。PSI将 以我们在眼睛跟踪和高分辨率视网膜成像方面的专业知识为基础，利用 实时视频稳像技术是在视觉和计算机科学的基础上发展起来的。PSI将开发一种即插即用- Play解决方案，可适用于任何需要图像稳定的成像平台。单机版 只需对现有平台进行最小修改即可集成的设备将有助于将 从研究实验室到常规临床应用的视网膜成像分辨率。

Project Summary/Abstract Physical Sciences Inc (PSI) proposes to develop a robust eye tracking technology to enhance the quality of high-resolution retinal imaging videos by significantly reducing the image artifacts induced by involuntary eye motion. The living human eye is constantly moving. A constant visual stimulus can make the photoreceptors or the ganglion cells (GC) become unresponsive. The eye movement constantly changes the stimuli that fall on the cones/GC’s, making the image clearer. However, eye motion has deleterious effects in retinal imaging and image stabilization is needed to attenuate these effects. Adaptive optics (AO) systems are being extended to precision stimulus delivery, microperimetry, measurement of intrinsic retinal signals, psychophysics, and structural and functional vision studies in the research lab and the clinic. The multi-channel AO retinal imager (MAORI) developed by PSI is a new tool for researchers and clinicians to investigate and monitor changes of retinal microstructures due to disease progression or response to treatment. However, one of the main challenges for routine clinical application of high- resolution retinal imaging remains eye motion. We propose to use retinal tracking to improve the efficiency of an imaging session by significantly reducing the number of uncorrectable images in each data set, and therefore by minimizing the time that both the patient and the medical personnel spend imaging. PSI will build on our expertise in eye tracking and high-resolution retinal imaging and leverage recent advances in real-time video image stabilization developed in vision and computer science. PSI will develop a plug-and- play solution that can be adapted to any imaging platform that requires image stabilization. A stand-alone device that can be incorporated with minimal modifications into existing platforms will help transfer high- resolution retinal imaging from research labs into routine clinical applications.