Measurement of Retinal Nerves and Blood Vessels as Markers for Type 1 Diabetes
测量视网膜神经和血管作为 1 型糖尿病的标志物
基本信息
- 批准号:9754819
- 负责人:
- 金额:$ 50.47万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-08-01 至 2022-07-31
- 项目状态:已结题
- 来源:
- 关键词:AffectAxonBiological MarkersBlood VesselsBlood capillariesBostonCharacteristicsClinicClinicalClinical EngineeringClinical ManagementCollaborationsComplexComplications of Diabetes MellitusDataDetectionDiabetes MellitusDiabetic RetinopathyDiagnosisDiagnosticDiseaseDisease MarkerDisease ProgressionEarly DiagnosisEvolutionFiber OpticsFundingHistopathologyHuman VolunteersImageImageryImaging TechniquesImaging technologyIncidenceInsulin-Dependent Diabetes MellitusKnowledgeLaboratory ResearchLasersLightMarket ResearchMeasurementMedicalMetabolicModalityMonitorMorphologic artifactsMorphologyNerveNerve FibersNeuronsOphthalmologistOphthalmoscopyOptical Coherence TomographyPatientsPediatric HospitalsPericytesPhasePhotoreceptorsPopulationPositioning AttributePublicationsRecording of previous eventsReperfusion TherapyResearchResearch PersonnelResolutionRetinaRetinalScanningSchemeStructureSystemTechniquesTechnologyTestingTissuesTractionTreatment EfficacyUnited States National Institutes of HealthVisionVision researchadaptive opticsadaptive optics scanning laser ophthalmoscopybaseclinical Diagnosisclinical investigationcommercializationdesigndisease diagnosisearly detection biomarkersfundamental researchhealthy volunteerhigh resolution imagingimagerimaging approachimaging capabilitiesimaging modalityimaging platformimprovedin vivoinstrumentmultimodalityneurovascularnew technologynext generationnon-invasive imagingnoveloptical imagingphysical scienceprogramsprototyperetina blood vessel structureretinal imagingspecific biomarkerstooltreatment responsevolunteer
项目摘要
Project Summary/Abstract
There is currently a significant need for new non-invasive imaging techniques able to accurately
quantify biomarkers for early detection, diagnosis, and quantification of complications in type 1 diabetes
(T1D) such as diabetic retinopathy (DR). Physical Sciences Inc. (PSI) proposes to develop an imaging
platform based on a new detection arrangement retrofitted to an existing high-resolution retinal imaging
platform that includes adaptive optics-assisted scanning laser ophthalmoscopy (AO-SLO) and Optical
Coherence Tomography (OCT). The new technique will allow for visualization and quantification of blood
vessels structure and nerve bundle arrangement with exquisite details afforded by AO. The proposed
detection scheme will be first tested and demonstrated using an existing multimodal AO retinal imager
(MAORI) in Phase I and then in Phase II a new MAORI prototype will be developed specifically for imaging
particular characteristics of retinal alterations induces by diabetes. Specific biomarkers for T1D
complications will be defined based on patient data acquired by our collaborators from Boston Children's
Hospital. About 40 patients with different stages of DR will be imaged during the Phase II Program.
PSI has a long, successful history of developing and commercializing high-resolution retinal imagers for
the ophthalmic research market. PSI and our collaborators have recognized that one of the main
impediments in developing a clinical market for AO-SLO's is that there have been few in-depth studies on
the medical application of AO imagers for disease diagnosis and tracking the efficacy of treatments.
Despite a relatively large number of research publications on the benefits of AO on understanding
fundamental aspects of vision, so far AO has not gained traction in the clinical market. However, given the
large incidence of neurovascular diseases, it is possible that the proposed application to use high-
resolution retinal imaging to investigate the retinal changes due to diabetes will generate significant drive to
bring AO closer to the clinical market. Therefore, PSI is requesting funding for developing this technology
with a potentially significant impact on vision research and subsequently on the clinical diagnosis and
management of DR.
项目总结/文摘
项目成果
期刊论文数量(0)
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会议论文数量(0)
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Mircea Mujat其他文献
Mircea Mujat的其他文献
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{{ truncateString('Mircea Mujat', 18)}}的其他基金
Evaluation of photoreceptors health and function in diabetic retinopathy patients using a high-resolution retinal imaging device with controlled light stimulus
使用受控光刺激的高分辨率视网膜成像设备评估糖尿病视网膜病变患者的光感受器健康和功能
- 批准号:
10696696 - 财政年份:2023
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Ultra-high speed AO-OCT clinical system to image ganglion cells and microglia
超高速 AO-OCT 临床系统对神经节细胞和小胶质细胞进行成像
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10547181 - 财政年份:2022
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Ultra-high speed AO-OCT clinical system to image ganglion cells and microglia
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10705315 - 财政年份:2022
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Versatile Eye Tracking for Improved High-resolution Retinal Imaging
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Comprehensive imaging and quantification of blood flow for investigating ocular diseases without additional contrast agent
无需额外造影剂即可对血流进行全面成像和量化以研究眼部疾病
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10349594 - 财政年份:2019
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Multi-modal AO-LSO Phase Gradient Imaging of the Inner Retina
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- 批准号:
9788095 - 财政年份:2014
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Combined RCM and PSOCT for skin cancer imaging
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Combined RCM and PSOCT for skin cancer imaging
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8251261 - 财政年份:2012
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$ 50.47万 - 项目类别:
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