Combined RCM and PSOCT for skin cancer imaging

结合 RCM 和 PSOCT 进行皮肤癌成像

• 批准号: 8251261
• 负责人: Mircea Mujat
• 金额: $ 16.21万
• 依托单位: PHYSICAL SCIENCES, INC
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8251261
• 关键词: Algorithms; Am 80; Basal cell carcinoma; Benign; Biological; Biopsy; Birefringence; Cancer Patient; Clinical; Collaborations; Confocal Microscopy; Dermal; Dermatologist; Dermatology; Dermis; Dermoscopy; Detection; Devices; Diagnosis; Diagnostic; Diagnostic Neoplasm Staging; Emotional; Engineering; Epidermis; Face; Feedback; Head; Health Care Costs; Healthcare Systems; Human; Image; Imaging technology; Invaded; Investigation; Lateral; Lesion; Malignant Neoplasms; Marketing; Measures; Memorial Sloan-Kettering Cancer Center; Methods; Microscope; Modality; Mohs Surgery; Morphology; Nuclear; Operative Surgical Procedures; Optical Coherence Tomography; Optics; Papillary; Pathologist; Pathology; Patients; Performance; Phase; Pigments; Pilot Projects; Property; Relative (related person); Reporting; Research; Resolution; Screening procedure; Sensitivity and Specificity; Skin; Skin Cancer; Specificity; Specimen; Squamous cell carcinoma; Staging; Staining method; Stains; System; Technology; Testing; Time; Tissues; Training; Validation; Visual; base; cancer diagnosis; cancer imaging; cancer site; cost; design; experience; imaging Segmentation; improved; in vivo; instrument; melanoma; novel; optical imaging; phase 2 study; physical science; programs; prototype; skin lesion; success; treatment planning; tv watching; volunteer

DESCRIPTION (provided by applicant): Physical Sciences, Inc. (PSI), in collaboration with Memorial Sloan Kettering Cancer Center (MSKCC) and Lucid, Inc., proposes to investigate the use of combined reflectance confocal microscopy- polarization sensitive optical coherence tomography (RCM-PSOCT) for in vivo diagnosis of skin cancers. Both RCM and OCT are powerful technologies with proven success in human skin imaging. While RCM provides en face images with nuclear-level resolution in superficial skin, to depths of about 200 mm, OCT provides cross-sectional images with structural-level resolution in the deeper skin layers, to depths of at least 1 mm. Furthermore, PSOCT measures skin birefringence, and thus accurately differentiates between the dermal and epidermal skin layers. Therefore, the complementary capabilities of these two optical technologies may be exploited to offer a clinically comprehensive set of parameters for diagnostics which neither modality can provide by itself: presence and lateral spread of cancer, location of the dermo- epidermal junction and depth (stage) of invasion. Thus, this technology could help clinicians to provide more reliable diagnosis of suspicious skin lesions and significantly reduce the number of unnecessary biopsies. For a preliminary investigation of this powerful dual-mode imaging approach, a novel method for automated localization of the dermo-epidermal (DE) junction is proposed. In Phase I we propose to develop a benchtop instrument that will combine RCM and PSOCT within the same optical layout. Preliminary testing of this instrument will be performed on excised tissue specimens and on the normal skin of several volunteers. Based on Phase I conclusions, this instrument will be improved and a clinical prototype will be built and tested in a clinical setting on a larger number of normal and skin cancer patients during the Phase II study. PUBLIC HEALTH RELEVANCE: Reflectance confocal microscopy and optical coherence tomography are powerful optical imaging technologies for imaging biological tissue at the micron scale level. The combination of these technologies into an integrated microscope will enable noninvasive and real-time screening and diagnosis of skin cancers with high sensitivity and specificity, and thus could significantly reduce the number of unnecessary biopsies. Besides the elimination of emotional costs and patient discomfort, this technology may significantly reduce US healthcare costs by eliminating unnecessary biopsies.

描述(由申请人提供)：物理科学公司(PSI)与纪念斯隆-凯特琳癌症中心(MSKCC)和Lucid，Inc.合作，建议研究使用组合反射共聚焦显微镜-偏振敏感光学相干断层扫描(RCM-PSOCT)在体内诊断皮肤癌。RCM和OCT都是强大的技术，在人体皮肤成像方面都取得了成功。RCM在表层皮肤提供核级分辨率的EN面部图像，深度约200毫米，而OCT提供更深皮肤层的结构级分辨率横断面图像，深度至少1毫米。此外，PSOCT测量皮肤双折射，从而准确区分真皮和表皮皮肤层。因此，这两种光学技术的互补能力可以被用来提供一套临床上全面的诊断参数，这两种方法都不能单独提供：癌症的存在和侧向扩散，真皮-表皮交界处的位置和侵袭的深度(阶段)。因此，这项技术可以帮助临床医生对可疑的皮肤病变提供更可靠的诊断，并显著减少不必要的活检数量。为了对这一强大的双模成像方法进行初步研究，提出了一种新的自动定位真皮-表皮(DE)交界处的方法。在第一阶段，我们建议开发一种台式仪器，它将在相同的光学布局中结合RCM和PSOCT。该仪器的初步测试将在切除的组织样本和几名志愿者的正常皮肤上进行。在第一阶段结论的基础上，该仪器将得到改进，并将在第二阶段研究期间建立临床原型，并在临床环境中对更多的正常和皮肤癌患者进行测试。 与公共健康相关：反射共聚焦显微镜和光学相干层析成像是在微米级别对生物组织成像的强大光学成像技术。将这些技术结合到一个集成显微镜中，将能够以高灵敏度和特异性对皮肤癌进行非侵入性和实时筛查和诊断，从而可以显著减少不必要的活检数量。除了消除情感成本和患者不适之外，这项技术还可以通过消除不必要的活组织检查来显著降低美国的医疗成本。