Comprehensive imaging and quantification of blood flow for investigating ocular diseases without additional contrast agent

无需额外造影剂即可对血流进行全面成像和量化以研究眼部疾病

基本信息

批准号：
10295545
负责人：
Mircea Mujat
金额：
$ 67.83万
依托单位：
PHYSICAL SCIENCES, INC
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-01 至 2023-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10295545
关键词：
3-Dimensional Address Age related macular degeneration Animal Model Animals Area Biological Markers Blindness Blood Vessels Blood Volume Blood flow Caliber Choroid Clinic Clinical Clinical Engineering Clinical Research Collaborations Contrast Media Coupled Data Detection Development Diabetic Retinopathy Diagnostic Imaging Disease Ensure Evaluation Eye Eye diseases Feasibility Studies Flowmetry Fostering Foundations Funding Future Glaucoma Human Volunteers Image Imaging Device Imaging technology Individual Institutional Review Boards Knowledge Laboratory Research Location Maps Measurable Measurement Microgravity Monitor Morphology Multimodal Imaging New York Ophthalmologist Ophthalmology Optical Coherence Tomography Outcome Patients Pattern Phase Positioning Attribute Protocols documentation Recording of previous events Research Resolution Retina Retinal Degeneration Retinal Diseases Risk Rodent Rodent Diseases Rodent Model Scanning Scientist Severity of illness Structure System Techniques Technology Testing Thick Translations United States National Aeronautics and Space Administration Universities Vision Visualization base blood flow measurement clinical practice commercialization density design experience hemodynamics human subject imager imaging approach imaging modality imaging platform imaging program imaging study imaging system improved in vivo instrument instrumentation medical schools multimodality neurovascular new technology novel novel diagnostics patient population physical science programs prototype recruit research and development retinal imaging three dimensional structure

项目摘要

Project Summary/Abstract Physical Sciences Inc. (PSI) in collaboration with New York University (NYU) School of Medicine proposes to develop a novel ophthalmic imaging platform for characterizing retinal morphology and monitoring ocular blood flow abnormalities. This platform will combine non-invasive measurements of retina/choroid structure and ocular blood flow based on optical coherence tomography (OCT) and wide- field semi-quantitative global flow visualization using line-scanning Doppler flowmetry (LSDF). The combination of these two imaging modalities within the same imaging platform enables comprehensive assessment of blood flow in the retina and choroid. This novel imaging platform will enable imaging studies in animals and human subjects with normal vision or with various retinal diseases. Prior PSI experience in developing advanced ophthalmic imaging systems coupled with our collaborators' expertise in Ophthalmology will be leveraged to ensure the successful outcome of this important R&D program. A feasibility study will be performed during the Phase I program by imaging normal and diseased rodent models using a benchtop instrument. A clinical prototype instrument will be manufactured and tested clinically in Phase II in the NYU population of patients to highlight hemodynamic retinal biomarkers. We choose to focus on diseases that are the leading causes of blindness including, age-related macular degeneration (AMD), diabetic retinopathy (DR), and glaucoma to demonstrate the clinical utility of our novel system. We will recruit healthy individuals to set a reference, and subjects with AMD, DR, and glaucoma at a wide range of disease severity. In all of these conditions, the ability to record in vivo blood flow will provide novel information that will open new diagnostic and treatment avenues.

项目摘要/摘要物理科学公司（PSI）与纽约大学（NYU）医学院合作建议开发一个新型的眼科成像平台，以表征视网膜形态和监测眼血流异常。该平台将结合非侵入性测量基于光学相干断层扫描（OCT）和广泛的视网膜/脉络膜结构和眼流量使用线扫描多普勒流量计（LSDF）的场半定量全球流动可视化。这同一成像平台内这两种成像方式的组合可以综合评估视网膜和脉络膜中的血流。这个新颖的成像平台将启用成像对具有正常视力或各种视网膜疾病的动物和人类受试者进行研究。先前的psi 开发高级眼科成像系统的经验以及我们的合作者的专业知识将利用眼科研究，以确保这项重要的研发计划的成功结果。通过对正常和患病的啮齿动物进行成像，将在I阶段计划中进行可行性研究使用台式仪器的型号。将制造和测试临床原型仪器临床在II期的纽约大学患者人群中，以突出血液动力学视网膜生物标志物。我们选择专注于失明的主要原因，包括与年龄有关的黄斑退化（AMD），糖尿病性视网膜病（DR）和青光眼，以证明我们的小说的临床实用性系统。我们将招募健康的个体来设置参考，并接受AMD，DR和青光眼的受试者广泛的疾病严重程度。在所有这些情况下，记录体内血流的能力将提供新的信息，以开放新的诊断和治疗途径。