水生生物医学模型设施核心-猫眼课题宝

水生生物医学模型设施核心

批准号：

8448281

负责人：

Robyn L Tanguay

金额：

$23.66万

依托单位：

OREGON STATE UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/8448281

关键词：

Adult Age Analytical Chemistry Animals Autopsy Behavior assessment Binding Sites Biological Biological Assay Biological Markers Biology Carcinogens Cells Chemical Exposure Chemicals Chemoprevention Collaborations Communication Core Facility Data Databases Deposition Development Devices Disease Dose Electron Microscope Embryo Embryo Transfer Engineering Environment Equipment Experimental Designs Family Female Gene Expression Gene Silencing Gene-Modified Genes Genetic Genetic Screening Genome Germ Lines Goals Health Sciences Hour Human Resources Image In Situ Hybridization Institutes Investments Laboratories Laboratory Research Legal patent Lesion Licensing Longevity Mammals Mass Spectrum Analysis Messenger RNA Methods Microfluidics Microinjections Mission Modeling Molecular Molecular Analysis Mutation Oncorhynchus mykiss Oregon Pathway interactions Physiologic pulse Play Population Predisposition Process Productivity Proteins Proteomics Protocols documentation Quarantine Records Research Research Personnel Resistance Resources Role Scientist Services Signal Transduction Site Sorting - Cell Movement Stable Isotope Labeling Staging Stress System Techniques Technology Testing Toxicity Tests Transgenes Transgenic Organisms Translational Research United States National Academy of Sciences United States National Institutes of Health Universities Visit Water Work Zebrafish Zinc Fingers base biocomputing carcinogenesis chemical genetics cost data sharing design dietary supplements digital egg embryonic stem cell environmental stressor experience fetal follow-up gene repression genome-wide human disease improved interest meetings micromanipulator mutant nanolitre novel novel therapeutic intervention nuclease pathogen pressure professor programs prototype research study response screening sperm cell success transmission process zebrafish genome

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中文摘要

翻译

水生生物医学模型设备核心(ABMFC)的使命是利用水生模型的独特优势来发现影响人类疾病发展的环境-生物相互作用。ABMFC致力于实现以下长期目标：？了解与“正常”发展计划相互作用和干扰的一整套环境应激源，定义在增加对环境应激源的敏感性方面起作用的基因，？确定人类疾病的早期和预测性生物标志物，并发现新的治疗干预措施，？确定降低终生易患疾病的最佳胎儿环境，以及扩大使用化学遗传学来理解环境应激源的作用模式。

英文摘要

The mission of Aquatic Biomedical Models Facility Core (ABMFC) is to exploit the unique advantages of aquatic models to discover the environmental-biological interactions that influence the development of human disease. The ABMFC is dedicated to achieving these long-term goals: ¿ understand the full suite of environmental stressors that interact with and perturb the "normal" developmental program, define the genes that play a role in increased susceptibility to environmental stressors, ¿ identify early and predictive biomarkers of human disease and discover novel therapeutic interventions, ¿ define the optimal fetal environment that reduces lifelong susceptibility to disease, and ¿ expand the use of chemical genetics to understand the mode of action of environmental stressors.

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