Dietary Factors and Neuroimaging Markers

饮食因素和神经影像标记物

• 批准号: 8510290
• 负责人: Yian Gu
• 金额: $ 10.1万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-01 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8510290
• 关键词: Adherence; Age; Aging; Atrophic; Baby Booms; Biological; Brain; Brain imaging; Cerebrovascular Circulation; Cerebrovascular Disorders; Clinical; Cognitive; Communities; Cross-Sectional Studies; Data; Dementia; Diet; Dietary Factors; Dietary Practices; Elderly; Elements; Epidemiology; Food; Functional disorder; Generations; Height; Human; Image; Image Analysis; Impaired cognition; Individual; Infarction; Intake; Literature; Longitudinal Studies; Low Prevalence; Magnetic Resonance Imaging; Measurement; Measures; Mentors; Methods; New York; Nutrient; Nutritional; Observational Study; Outcome; Participant; Performance; Phase; Population; Population Study; Principal Component Analysis; Reporting; Reproducibility; Research; Research Ethics; Research Methodology; Risk; Risk Assessment; Role; Sample Size; Sampling; Series; Stroke; Techniques; Testing; Thick; Time; Training; Washington; Work; age related; aging brain; aging population; base; brain pathway; brain volume; cerebral atrophy; cerebrovascular; cohort; interest; nervous system disorder; neuroimaging; public health relevance; validation studies; white matter

DESCRIPTION (provided by applicant): Promoting healthy brain aging is of increasing concern to an aging population as the baby boom generation approaches age 65. Dietary management has received a great deal of interest as mounting evidence from observational studies suggests dietary factors may be associated with the risk of developing neurological diseases, including cerebrovascular diseases and cognitive decline, in the elderly. Many of the neurological diseases of aging are known to develop as a result of subclinical brain changes. These brain changes can now be visualized and quantified using MRI; therefore MRI markers of brain changes are worth being considered to better understand the association between diet and brain aging. Neuroimaging markers are extremely sensitive measurements of changes occurring in the aging brain, and can also help us understand better the associations of different aspects of diet with specific changes of brain dysfunction. Current literature on the associations between diet and neuroimaging markers in the elderly has been extremely sparse. In particular, dietary patterns and longitudinal change of neuroimaging marker have been rarely investigated. Our previous work shows that higher adherence to a Mediterranean-type diet was associated with lower prevalence of subclinical brain infarcts but not white matter hyperintensity, emphasizing the value of exploring dietary patterns and multiple imaging markers. The overall aim of this study is to examine how dietary factors are related with brain changes seen on MRI imaging. Specifically, the proposed study will examine the association between dietary factors (both individual nutrients and dietary patterns) and neuroimaging changes of the brain (including global and regional brain atrophy measured by volume and cortical thickness, white matter hyperintensity, subclinical brain infarcts) through a series of studies including: during the mentored phase, (1) a cross-sectional study of the relationship between baseline dietary factors and above-mentioned neuroimaging markers using data from the Washington Heights Inwood Columbia Aging Project (WHICAP) -II Imaging Study; and during the independent phase, (2) a longitudinal study of the association between baseline diet and change of these imaging markers in a subset of WHICAP-II Imaging Study participants who have repeated imaging evaluations, (3) a cross-sectional replication study based on data from an on-going WHICAP-2010 Imaging Study to examine the reproducibility of the study (1) findings, and (4) a cross-sectional exploratory study based on data from an on-going WHICAP-2010 Imaging Study to explore the relationship between diet and two additional MRI markers collected in WHICAP-2010, cerebral blood flow and brain connectivity. Findings from this study will contribute to our understanding of the role of dietary factors in imaging markers of brain aging.

描述（由申请人提供）：随着婴儿潮一代接近 65 岁，促进健康的大脑老化越来越受到老龄化人口的关注。饮食管理受到了极大的关注，因为越来越多的观察性研究证据表明饮食因素可能与老年人患神经系统疾病（包括脑血管疾病和认知能力下降）的风险相关。已知许多衰老神经系统疾病是由于亚临床大脑变化而产生的。现在可以使用 MRI 来可视化和量化这些大脑变化；因此，值得考虑大脑变化的 MRI 标记，以更好地了解饮食与大脑衰老之间的关联。神经影像标记物是对衰老大脑中发生的变化极其敏感的测量，也可以帮助我们更好地了解饮食的不同方面与大脑功能障碍的特定变化之间的关联。目前关于老年人饮食与神经影像标记物之间关系的文献极其稀少。特别是，饮食模式和神经影像标记物的纵向变化很少被研究。我们之前的研究表明，较高程度地坚持地中海式饮食与亚临床脑梗塞患病率较低有关，但与白质高信号无关，这强调了探索饮食模式和多种成像标记物的价值。这项研究的总体目的是研究饮食因素与 MRI 成像中看到的大脑变化之间的关系。具体来说，拟议的研究将通过一系列研究来检查饮食因素（个人营养素和饮食模式）与大脑神经影像变化（包括通过体积和皮质厚度测量的全局和区域脑萎缩、白质高信号、亚临床脑梗死）之间的关联，包括：在指导阶段，（1）基线饮食因素与上述神经影像标记之间关系的横断面研究 使用华盛顿高地因伍德哥伦比亚老龄化项目 (WHICAP)-II 成像研究的数据；在独立阶段，(2) 对重复影像学评估的 WHICAP-II 影像学研究参与者子集中的基线饮食与这些影像学标志物变化之间的关联进行纵向研究，(3) 基于正在进行的 WHICAP-2010 影像学研究的数据进行横断面复制研究，以检验研究的可重复性 (1) 结果，以及 (4) 基于以下数据的横断面探索性研究 一项正在进行的 WHICAP-2010 成像研究，旨在探索饮食与 WHICAP-2010 中收集的另外两个 MRI 标记（脑血流量和大脑连接性）之间的关系。这项研究的结果将有助于我们了解饮食因素在大脑衰老成像标志物中的作用。