Dietary Factors and Neuroimaging Markers

饮食因素和神经影像标记物

• 批准号: 8666701
• 负责人: Yian Gu
• 金额: $ 10.1万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-01 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8666701
• 关键词: Adherence; Age; Aging; Atrophic; Baby Booms; Biological; Brain; Brain imaging; Cerebrovascular Circulation; Cerebrovascular Disorders; Clinical; Cognitive; Communities; Cross-Sectional Studies; Data; Dementia; Diet; Dietary Factors; Dietary Practices; Elderly; Elements; Epidemiology; Food; Functional disorder; Generations; Height; Human; Image; Image Analysis; Impaired cognition; Individual; Infarction; Intake; Literature; Longitudinal Studies; Low Prevalence; Magnetic Resonance Imaging; Measurement; Measures; Mentors; Methods; New York; Nutrient; Nutritional; Observational Study; Outcome; Participant; Performance; Phase; Population; Population Study; Principal Component Analysis; Reporting; Reproducibility; Research; Research Ethics; Research Methodology; Risk; Risk Assessment; Role; Sample Size; Sampling; Series; Stroke; Techniques; Testing; Thick; Time; Training; Washington; White Matter Hyperintensity; Work; age related; aging brain; aging population; base; brain pathway; brain volume; cerebral atrophy; cerebrovascular; cohort; interest; nervous system disorder; neuroimaging; public health relevance; validation studies

DESCRIPTION (provided by applicant): Promoting healthy brain aging is of increasing concern to an aging population as the baby boom generation approaches age 65. Dietary management has received a great deal of interest as mounting evidence from observational studies suggests dietary factors may be associated with the risk of developing neurological diseases, including cerebrovascular diseases and cognitive decline, in the elderly. Many of the neurological diseases of aging are known to develop as a result of subclinical brain changes. These brain changes can now be visualized and quantified using MRI; therefore MRI markers of brain changes are worth being considered to better understand the association between diet and brain aging. Neuroimaging markers are extremely sensitive measurements of changes occurring in the aging brain, and can also help us understand better the associations of different aspects of diet with specific changes of brain dysfunction. Current literature on the associations between diet and neuroimaging markers in the elderly has been extremely sparse. In particular, dietary patterns and longitudinal change of neuroimaging marker have been rarely investigated. Our previous work shows that higher adherence to a Mediterranean-type diet was associated with lower prevalence of subclinical brain infarcts but not white matter hyperintensity, emphasizing the value of exploring dietary patterns and multiple imaging markers. The overall aim of this study is to examine how dietary factors are related with brain changes seen on MRI imaging. Specifically, the proposed study will examine the association between dietary factors (both individual nutrients and dietary patterns) and neuroimaging changes of the brain (including global and regional brain atrophy measured by volume and cortical thickness, white matter hyperintensity, subclinical brain infarcts) through a series of studies including: during the mentored phase, (1) a cross-sectional study of the relationship between baseline dietary factors and above-mentioned neuroimaging markers using data from the Washington Heights Inwood Columbia Aging Project (WHICAP) -II Imaging Study; and during the independent phase, (2) a longitudinal study of the association between baseline diet and change of these imaging markers in a subset of WHICAP-II Imaging Study participants who have repeated imaging evaluations, (3) a cross-sectional replication study based on data from an on-going WHICAP-2010 Imaging Study to examine the reproducibility of the study (1) findings, and (4) a cross-sectional exploratory study based on data from an on-going WHICAP-2010 Imaging Study to explore the relationship between diet and two additional MRI markers collected in WHICAP-2010, cerebral blood flow and brain connectivity. Findings from this study will contribute to our understanding of the role of dietary factors in imaging markers of brain aging.

描述（由申请人提供）：随着婴儿繁荣的产生方法65岁，促进健康的大脑衰老对衰老人群的关注越来越大。饮食管理引起了极大的兴趣，因为观察性研究的越来越多的证据表明，饮食因素可能与患有神经系统疾病的风险有关，包括脑部疾病和认知性疾病的风险。众所周知，许多衰老的神经系统疾病会因亚临床大脑变化而发展。现在可以使用MRI对这些大脑变化进行可视化和量化。因此，值得考虑的大脑变化的MRI标记以更好地了解饮食与大脑衰老之间的关联。神经影像学标记是对衰老大脑发生变化的极其敏感的测量，也可以帮助我们更好地理解饮食不同方面的关联与脑功能障碍的特定变化。当前关于老年人饮食与神经影像标记之间关联的文献非常稀疏。特别是，很少研究饮食模式和神经影像标记的纵向变化。我们以前的工作表明，对地中海型饮食的依从性较高与亚临床脑梗塞的患病率较低，而不是白质超强度，这强调了探索饮食模式和多个成像标记的价值。这项研究的总体目的是检查饮食因素与MRI成像上看到的大脑变化的关系。 Specifically, the proposed study will examine the association between dietary factors (both individual nutrients and dietary patterns) and neuroimaging changes of the brain (including global and regional brain atrophy measured by volume and cortical thickness, white matter hyperintensity, subclinical brain infarcts) through a series of studies including: during the mentored phase, (1) a cross-sectional study of the relationship between baseline dietary factors and above-mentioned neuroimaging markers使用华盛顿高地Inwood哥伦比亚老化项目（WHICAP）-II成像研究的数据；在独立阶段，（2）对基线饮食与这些成像标记之间的关联的纵向研究，在WHICAP-II成像研究参与者的子集中，他们重复进行了成像评估，（3）基于正在进行的WHICAP-2010成像研究的数据基于研究的研究，该研究的研究（3）基于研究的研究（1）研究（1）研究（1），（1）研究（4）一项正在进行的WHICAP-2010成像研究，旨在探索饮食与2010年WHICAP-2010，脑血流和大脑连通性收集的另外两个MRI标记之间的关系。这项研究的发现将有助于我们理解饮食因素在脑衰老的成像标记中的作用。

项目成果

Self-Reported Sleep Disordered Breathing as Risk Factor for Mortality in the Elderly.

自我报告睡眠呼吸障碍是老年人死亡的危险因素。

• DOI: 10.1016/j.jstrokecerebrovasdis.2016.03.008
• 发表时间: 2016
• 期刊: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
• 作者: Tsapanou,Angeliki;Gu,Yian;O'Shea,Deirdre;Manly,Jennifer;Schupf,Nicole;Scarmeas,Nikolaos;Stern,Yaakov
• 通讯作者: Stern,Yaakov