Biostatistics and Research Information Systems Core

生物统计和研究信息系统核心

• 批准号: 8673567
• 负责人: STEPHEN B. KRITCHEVSKY
• 金额: $ 11.66万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8673567
• 关键词: Address; Aging; Aging-Related Process; American; Area; Award; Baptist Church; Biometry; Brain; Clinic; Clinical; Clinical Data; Clinical Trials; Collaborations; Collection; Commit; Communities; Computerized Medical Record; Consent Forms; Data; Data Analyses; Data Collection; Development; Devices; Educational process of instructing; Evaluation; Faculty; Fostering; Funding; Goals; Health Sciences; Image; Individual; Informatics; Information Systems; Informed Consent; Instruction; Intervention; Intervention Studies; Investigation; Knowledge; Lead; Learning; Machine Learning; Medical center; Mentors; Methods; Modeling; Monitor; Movement; Online Systems; Participant; Pathway interactions; Patients; Pilot Projects; Play; Psychometrics; Public Health; Publications; Qualifying; Questionnaires; Randomized; Research; Research Design; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resource Sharing; Role; Safety; Sample Size; Science; Source; Statistical Data Interpretation; Statistical Methods; Stream; System; Technology; Thinking; Training; Translating; Translations; age related; analytical method; base; community setting; computerized data processing; data management; design; disability; forest; functional decline; genome wide association study; improved; innovation; markov model; member; method development; next generation; novel; prevent; statistics; success; tool; touchscreen

PROJECT SUMMARY (See instructions): The goal of the WFU OAIC Biostatistics and Research Information Systems Core (BIC) is to build upon our strong successes in biostatistical collaboration and to develop a broader class of statistics/informatics tools that are tailored to research in aging. The proposed Core is comprised of a team of highly qualified investigators/staff with expertise in the design and management of observational, pilot and interventional studies, centralized and decentralized data management, forms design and data processing, image archival, psychometrics, statistical analysis of data from multiple study designs, GWAS analyses, and development of novel statistical methods. These individuals are committed to the WFU OAlC's global aims to: (1) discover; (2) evaluate; and (3) translate interventions to treat and prevent disability based on integrating novel pathways of functional decline; and (4) train the next generation of leaders in aging research. The Specific Aims of the BIC are: 1. To participate as co-investigators for WFU OAIC projects (4 pilot studies (PES), 1 developmental projects (DP) and 8 externally funded projects (EPs)) related to OAlC's global aims. As co investigators, BIC members will be actively involved in study design and conduct (including recruitment monitoring, randomization, and safety monitoring); sample size determination; data management; and statistical analysis, interpretation and presentation/publication of results. 2. To play an integral role in training of OAlC-supported fellows and junior members of the BIC on the design, planning, conduct, and analysis of aging-related research projects. The BIC will also extend its strong record of discovery and evaluation with Specific Aims 3-4, which are to: 3. Develop additional innovative biostatistical applications/methods for analytical issues specifically associated with aging research. 4. Develop innovative research information collection systems to assist in carrying out studies in older participants and translate these tools into community- and clinic-based settings, in support of Aim 3 of the WFU OAIC overall goals.

项目摘要（见说明）：WFU OAIC生物统计和研究信息系统核心（BIC）的目标是建立在我们在生物统计合作方面的巨大成功，并开发更广泛的统计/信息学工具，为老龄化研究量身定制。拟定的核心研究由一组高素质的研究者/工作人员组成，他们在观察性、初步和干预性研究的设计和管理、集中和分散数据管理、表格设计和数据处理、图像存档、心理测量学、多项研究设计数据的统计分析、GWAS分析和新型统计方法开发方面具有专业知识。这些人致力于WFU OAlC的全球目标：（1）发现;（2）评估;和（3）翻译干预措施，以治疗和预防基于整合功能衰退的新途径的残疾;和（4）培养下一代领导人在老龄化研究。 BIC的具体目标是： 1.作为共同研究员参与世界大学联合会与阿拉伯国际合作组织全球目标有关的阿拉伯国际合作组织项目（4个试点研究（PES）、1个发展项目（DP）和8个外部资助项目（EP））。作为共同研究者，BIC成员将积极参与研究设计和实施（包括招募监查、随机化和安全性监查）;样本量确定;数据管理;以及统计分析、解释和结果展示/发表。 2.在培训OAlC支持的研究员和BIC的初级成员方面发挥不可或缺的作用，设计，规划，执行和分析与老龄化相关的研究项目。BIC还将通过具体目标3-4扩展其发现和评估的良好记录，这些目标是： 3.开发额外的创新生物统计应用程序/方法，用于分析与衰老研究相关的问题。 4.开发创新的研究信息收集系统，以协助在老年参与者中开展研究，并将这些工具转化为社区和诊所环境，以支持WFU OAIC总体目标的目标3。