MULTIPLEXED ECHO PLANAR IMAGING FOR NEUROSCIENCES

用于神经科学的多重回波平面成像

• 批准号: 8444427
• 负责人: David Alan Feinberg
• 金额: $ 83.2万
• 依托单位: ADVANCED MRI TECHNOLOGY, LLC
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-15 至 2015-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8444427
• 关键词: Abdomen; Acceleration; Algorithms; Alzheimer' s Disease; Anatomy; Brain; Brain imaging; Brain region; California; Cerebrovascular Disorders; Chemicals; Clinical; Code; Computer software; Data; Diagnostic; Diagnostic Imaging; Diffusion; Diffusion Magnetic Resonance Imaging; Echo-Planar Imaging; Family; Fatty acid glycerol esters; Fiber; Functional Magnetic Resonance Imaging; Human; Image; Imagery; Imaging Techniques; Magnetic Resonance Imaging; Maps; Measurement; Methods; Minnesota; Morphologic artifacts; Neurodegenerative Disorders; Neurons; Neurosciences; Neurosciences Research; Noise; Patients; Phase; Physiologic pulse; Predisposition; Program Development; Protocols documentation; Research Personnel; Research Subjects; Resolution; Sampling; San Francisco; Scanning; Scheme; Signal Transduction; Slice; Sorting - Cell Movement; Speed; Spinal; Stroke; Techniques; Technology; Testing; Thinking; Three-Dimensional Image; Time; Training; Universities; Work; Writing; base; blood oxygen level dependent; design; image reconstruction; improved; novel; prototype; reconstruction; research study; statistics; tool

DESCRIPTION (provided by applicant): MRI is a proven non-invasive technique that makes high resolution image of the brain. Echo planar imaging (EPI) is the most widely used MRI technique used for neurosciences due to its extremely fast imaging speed and unique contrast mechanisms. EPI combined with diffusion sensitive gradient pulses provides 3D visualization of axonal fibers, which reveals the connectional anatomy of the human brain. EPI is also nearly exclusively used for functional MRI (fMRI) given its extremely high sensitivity to changes in "blood oxygen level dependent" (BOLD) contrast in different regions of the brain, revealing maps of neuronal activity. We are proposing to develop a family of highly efficient new EPI sequences for diffusion and fMRI providing several times faster imaging of the brain. This new faster imaging technique works by multiplexing several images within the single-shot echo train, to produce several images instead of a single EPI image from a each train of signals, whereas only a single image is produced in the normal EPI pulse sequence. The new Multiplexed EPI imaging sequence will largely replace the use of the original EPI sequence invented by Peter Mansfield in 1978 that to date has been used for all neuroscience and clinical brain imaging. The availability of these Multiplexed EPI techniques will give researchers and clinicians the capability of performing high angular resolution diffusion imaging (HARDI) in scan times reduced from 25 minutes to 8 or 12 minutes scans and these scan times will be more tolerable by both patients and research subjects. The multiplexed EPI can scan many times faster or instead be used to provide more images that are thinner for higher resolution and reduced artifacts. The greatly accelerated scan times of the whole brain will enable new experiments in functional MRI at 7 Tesla and 3 Tesla. The sequence will be designed, implemented and evaluated on MRI scanners operating at 3T at University of California Berkeley and San Francisco and at 7T and 10.5T at University of Minnesota. Once the Multiplexed EPI sequence is fully evaluated and optimized, it will be made into a useful tool for basic and clinical neuroscience research, and for clinical diagnostic imaging.

描述（由申请人提供）：MRI是一种经过验证的非侵入性技术，可对大脑进行高分辨率成像。回波平面成像（EPI）由于其极快的成像速度和独特的对比机制，是用于神经科学的最广泛使用的MRI技术。EPI结合扩散敏感梯度脉冲提供轴突纤维的3D可视化，其揭示了人脑的连接解剖。EPI也几乎专门用于功能性MRI（fMRI），因为它对大脑不同区域的“血氧水平依赖”（BOLD）对比度变化具有极高的敏感性，可以显示神经元活动的地图。我们建议开发一系列高效的新EPI序列，用于扩散和功能磁共振成像，提供几倍的大脑成像速度。这种新的更快的成像技术通过在单次激发回波序列内多路复用多个图像来工作，以从每个信号序列产生多个图像而不是单个EPI图像，而在正常EPI脉冲序列中仅产生单个图像。新的多路复用EPI成像序列将在很大程度上取代彼得曼斯菲尔德在1978年发明的原始EPI序列的使用，该序列迄今已用于所有神经科学和临床脑成像。这些多路复用EPI技术的可用性将使研究人员和临床医生能够在从25分钟减少到8或12分钟扫描的扫描时间内执行高角分辨率扩散成像（HARDI），并且这些扫描时间将更容易被患者和研究受试者所耐受。多路复用的EPI可以更快地扫描许多倍，或者替代地用于提供更薄的更多图像，以获得更高的分辨率和减少的伪影。整个大脑的扫描时间大大加快，这将使功能性磁共振成像在7特斯拉和3特斯拉的新实验成为可能。该序列将在加州伯克利大学和旧金山弗朗西斯科的3T和明尼苏达大学的7T和10.5T下运行的MRI扫描仪上设计、实施和评价。一旦多重EPI序列得到充分评估和优化，它将成为基础和临床神经科学研究以及临床诊断成像的有用工具。