权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Degradable orthopedic hardware

可降解矫形硬件

基本信息

批准号：
9438859
负责人：
DAVID L. KAPLAN
金额：
$ 44.48万
依托单位：
TUFTS UNIVERSITY MEDFORD
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-03-01 至 2020-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9438859
关键词：
Address Alloys Animal Model Animals Biocompatible Materials Biological Assay Biomechanics Biomedical Engineering Bone Regeneration Bone remodeling Child Clinical Data Deposition Device Removal Devices Diagnostic radiologic examination Evaluation Excision Formulation Fracture Fixation Goals Gold Histologic Histology Image Analysis In Vitro Infection Inflammatory Kinetics Mechanics Metals Modeling Modification Molecular Weight Morphology Operative Surgical Procedures Orthopedics Osteolysis Outcome Patient-Focused Outcomes Polyglycolic Acid Porosity Property Proteins Rattus Reaction Recording of previous events Research Research Personnel Role Running Silk Stress Structure Surgeon System Testing Time TimeLine Tissues Titanium Variant X-Ray Computed Tomography base biodegradable polymer bone design healing implantation improved in vivo insight interest lead candidate mechanical properties meetings nano osteogenic poly(lactic acid)poly-L-lactic acid public health relevance repaired response retinal rods screening single photon emission computed tomography

项目摘要

DESCRIPTION: Degradable orthopedic repair devices would provide significant clinical benefits to overcome current limitations in bone remodeling, degradation kinetics and bone integration. Current options are limited primarily to nondegradable metals which have become the gold standard for orthopedic repairs due to robust mechanical properties and ease of implantation, while limitations of stress shielding, infections, bone remodeling and second surgical removals have shifted significant interest toward degradable devices. Orthopedic screws and plates composed of polylactic and polyglycolic acids have become lead candidates for degradable hardware with a reduced need for removal and improved bone remodeling. However, polylactic and polyglycolic acid screws and plates are associated with inflammatory reactions due to degradation products, osteolysis and incomplete bone remodeling. Thus, orthopedic hardware that has appropriate mechanical properties, tunable and full degradation and is pro-osteogenic would have a major impact on orthopedic repairs in promoting accelerated healing, reducing second surgeries and improving long-term patient outcomes. Our long term goal is to develop fully degradable screws, plates and rods using silk protein functionalized by bioactive molecules to promote healthy bone remodeling and integration. The objective of the proposed research is to determine the ability of the proposed silk format to meet the structural needs of degradable orthopedic systems and successfully direct pro-osteogenic remodeling. We hypothesize that functionalized silk orthopedic hardware can be tuned to fully degrade over a 6-12 month time while promoting osteointegration to optimize utility in orthopedic repairs and meeting mechanical requirements. Our extensive preliminary in vitro and in vivo data support this hypothesis. The rationale for this research is to gain fundamental insight into the role of functionalized and degradable orthopedic screws and plates in accelerating healing and directing successful bone remodeling. The anticipated outcomes are expected to have a substantial positive impact on orthopedic repairs by presenting hardware designs capable of meeting mechanical needs of fracture fixation and addressing current limitations and complications. An interdisciplinary team of investigators who have a history of collaborative efforts will conduct the studies [David Kaplan - silk biomaterials, bioengineering, Ara Nazarian - biomechanics/biomiaging and animal studies, Sam Lin and Brian Snyder - orthopedic surgeons].