Tissue Engineering Resource Center

组织工程资源中心

基本信息

  • 批准号:
    10213714
  • 负责人:
  • 金额:
    $ 32.78万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-09-16 至 2024-05-31
  • 项目状态:
    已结题

项目摘要

SUMMARY TRD1 will focus on the design and implementation of adaptive-responsive biomaterials to meet the goals of the P41. These are biomaterials that can sense and actuate cells or respond to the local environment to drive the functional restoration of complex tissue structures, in vitro and in vivo. The hypothesis is that biomaterial systems with integrated features for activation/response can provide specific benefits for designing scaffolds for restoration of tissue structure and function. These new material systems will be integrated with the needs and goals of the other TRDs to optimize tissue outcomes at both the fundamental and translational levels. The ultimate goal is to develop biomaterial systems for functional restoration of complex tissue structures based on the response to changes in the local environment (intrinsic signaling) or via applied changes (extrinsic signaling). The plans are to develop materials that provide adaptive responses to changes in local biology and conditions (e.g., pH, temperature reactive oxygen, enzymes) or to external signals (e.g., light, electric fields) to effect a change to improve tissue function or regeneration goals. Control of mechanical properties, degradation and release of bioactive factors to respond to local changes are examples of dynamic response-control goals. The core biomaterials will be based on biopolymers (e.g., elastins, collagens, silks, hyaluronic acid, others) as bioengineered variants and composites. Three specific aims will be pursued. Aim 1: Biomaterials that dynamically change properties in response to local signals. These biopolymer systems will provide core functions for sensing-response using silk-elastin chemistry and composite designs with hyaluronic acid and collagen, for a broad range of utility for different cell and tissue needs. Aim 2: Biomaterials that change properties on demand, in response to external stimuli. The focus will be on light activation systems (via specific chemistries) or electric field-mediated changes (via incorporated conductive components). The goal is to control the material volume, mechanics, and delivery of bioactive factors in an on-demand mode, using external sources (light, electric field), to control cell and tissue outcomes. Aim 3: “Smart” scaffolds for tissue regeneration and modeling of disease. Scaffold designs based on the materials from Aims 1 and 2 will be utilized to generate functional devices and tissue models for studies in TRD1, 2 and 3, in vitro and in vivo.
总结

项目成果

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DAVID L. KAPLAN的其他文献

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{{ truncateString('DAVID L. KAPLAN', 18)}}的其他基金

2023 Silk Proteins and the Transition to Biotechnologies Gordon Research Conference
2023 年丝蛋白和向生物技术的过渡戈登研究会议
  • 批准号:
    10681751
  • 财政年份:
    2023
  • 资助金额:
    $ 32.78万
  • 项目类别:
Tissue Engineering Resource Center
组织工程资源中心
  • 批准号:
    10434730
  • 财政年份:
    2019
  • 资助金额:
    $ 32.78万
  • 项目类别:
Tissue Engineering Resource Center
组织工程资源中心
  • 批准号:
    10683745
  • 财政年份:
    2019
  • 资助金额:
    $ 32.78万
  • 项目类别:
3D Intestinal Tissues
3D 肠道组织
  • 批准号:
    9312411
  • 财政年份:
    2017
  • 资助金额:
    $ 32.78万
  • 项目类别:
Functional three dimensional brain-like tissues to study mechanisms of traumatic brain injury
功能性三维类脑组织用于研究创伤性脑损伤的机制
  • 批准号:
    8942566
  • 财政年份:
    2015
  • 资助金额:
    $ 32.78万
  • 项目类别:
Degradable orthopedic hardware
可降解矫形硬件
  • 批准号:
    9438859
  • 财政年份:
    2015
  • 资助金额:
    $ 32.78万
  • 项目类别:
Degradable orthopedic hardware
可降解矫形硬件
  • 批准号:
    8881483
  • 财政年份:
    2015
  • 资助金额:
    $ 32.78万
  • 项目类别:
Functional three dimensional brain-like tissues to study mechanisms of traumatic brain injury
功能性三维类脑组织用于研究创伤性脑损伤的机制
  • 批准号:
    9266832
  • 财政年份:
    2015
  • 资助金额:
    $ 32.78万
  • 项目类别:
Multifunctional Tropoelastin-Silk Biomaterial Systems
多功能原弹性蛋白-丝生物材料系统
  • 批准号:
    8518096
  • 财政年份:
    2012
  • 资助金额:
    $ 32.78万
  • 项目类别:
In vitro bioreactor sys for platelet formation
用于血小板形成的体外生物反应器系统
  • 批准号:
    8723656
  • 财政年份:
    2012
  • 资助金额:
    $ 32.78万
  • 项目类别:

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