权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Tissue Engineering Resource Center

组织工程资源中心

基本信息

批准号：
10213714
负责人：
DAVID L. KAPLAN
金额：
$ 32.78万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-16 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10213714
关键词：
3D Print Biocompatible Materials Biological Biological Process Biology Biomedical Engineering Biopolymers Biotin Carbodiimides Cells Chemistry Cicatrix Collaborations Collagen Complex Coupling Crystallization Deposition Devices Disease model Elastin Environment Enzymes Extracellular Matrix Fiber Fibrosis Free Radicals Freeze Drying Gel Genetic Engineering Goals Higher Order Chromatin Structure Hyaluronic Acid Immune response In Vitro Inflammation Light Mechanics Mediating Microfluidics Modification Natural regeneration Outcome Oxygen Polymers Polysaccharides Property Reaction Reactive Oxygen Species Regenerative Medicine Resources Series Signal Transduction Silk Site Source Stimulus Streptavidin Structural Protein Structure Study models System Temperature Therapeutic Time Tissue Engineering Tissue Model Tissues Variant Vascularization aqueous base biomaterial compatibility copolymer crosslink cytokine design dynamic system electric field experience functional restoration improved in vivo mechanical properties monomer nerve supply preservation public health relevance regeneration model response restoration scaffold self assembly tissue regeneration tissue support frame

项目摘要

SUMMARY TRD1 will focus on the design and implementation of adaptive-responsive biomaterials to meet the goals of the P41. These are biomaterials that can sense and actuate cells or respond to the local environment to drive the functional restoration of complex tissue structures, in vitro and in vivo. The hypothesis is that biomaterial systems with integrated features for activation/response can provide specific benefits for designing scaffolds for restoration of tissue structure and function. These new material systems will be integrated with the needs and goals of the other TRDs to optimize tissue outcomes at both the fundamental and translational levels. The ultimate goal is to develop biomaterial systems for functional restoration of complex tissue structures based on the response to changes in the local environment (intrinsic signaling) or via applied changes (extrinsic signaling). The plans are to develop materials that provide adaptive responses to changes in local biology and conditions (e.g., pH, temperature reactive oxygen, enzymes) or to external signals (e.g., light, electric fields) to effect a change to improve tissue function or regeneration goals. Control of mechanical properties, degradation and release of bioactive factors to respond to local changes are examples of dynamic response-control goals. The core biomaterials will be based on biopolymers (e.g., elastins, collagens, silks, hyaluronic acid, others) as bioengineered variants and composites. Three specific aims will be pursued. Aim 1: Biomaterials that dynamically change properties in response to local signals. These biopolymer systems will provide core functions for sensing-response using silk-elastin chemistry and composite designs with hyaluronic acid and collagen, for a broad range of utility for different cell and tissue needs. Aim 2: Biomaterials that change properties on demand, in response to external stimuli. The focus will be on light activation systems (via specific chemistries) or electric field-mediated changes (via incorporated conductive components). The goal is to control the material volume, mechanics, and delivery of bioactive factors in an on-demand mode, using external sources (light, electric field), to control cell and tissue outcomes. Aim 3: “Smart” scaffolds for tissue regeneration and modeling of disease. Scaffold designs based on the materials from Aims 1 and 2 will be utilized to generate functional devices and tissue models for studies in TRD1, 2 and 3, in vitro and in vivo.

总结