Core 2 - Institutional Center Cores for Advanced Neuroimaging

核心 2 - 高级神经影像机构中心核心

• 批准号: 8551750
• 负责人: KAMIL UGURBIL
• 金额: $ 15.24万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8551750
• 关键词: 2,4-Dinitrophenol; Animal Model; Animals; Biochemical; Brain; Brain Diseases; Brain scan; Data; Data Quality; Detection; Disease Progression; Doctor of Philosophy; Effectiveness; Future; Human; Label; Link; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Modality; Monitor; Noise; Perfusion; Physiologic pulse; Positron-Emission Tomography; Reproducibility; Research; Resolution; Rodent; Signal Transduction; Surrogate Markers; System; Technical Expertise; Tracer; brain metabolism; brain research; improved; in vivo; molecular imaging; neurochemistry; neuroimaging; novel; programs; single photon emission computed tomography

2. MOLECULAR IMAGING CORE PI: Michael Garwood, PhD; co-PI: Jerry Froelich MD; Co-I Gulin Oz CORE AIM Magnetic resonance spectroscopy (MRS) and positron emission tomography (PET) are two major modalities of molecular imaging, which allow direct assessment of metabolite and tracer concentrations in brain in vivo. They are critically important in studies of neurochemistry, brain function and perfusion, and can provide surrogate markers to detect brain diseases, to monitor disease progression, and to evaluate the effectiveness of novel therapies. With MRS, the richness of the biochemical information and the accuracy of metabolite quantification are strongly linked to spectral quality. In this regard, the ultrahigh field MRI/MRS systems in the CMRR, particulariy the new 16.4 T rodent capable system, the 9.4 T animal system with [13]C DNP hyperpolarizer, the 7T human systems, and the future 10.5 T human system, offer major advantages. In particular, they provide superior signal-to-noise ratio (SNR) and spectral resolution, for improved reproducibility in the detection and quantification of brain metabolites. In addition, brain scans with human PET/CT, microPET/CT, and Neuro SPECT are now available in the recently expanded CMRR.

2.分子成像核心 派：迈克尔·加伍德，博士；联合派：曾傑瑞，弗罗里奇医学博士；联合-I古林·奥兹 核心目标 磁共振波谱(MRS)和正电子发射断层扫描(PET)是分子成像的两种主要方式，可以直接评估活体脑内代谢物和示踪剂的浓度。它们在神经化学、脑功能和血流灌注的研究中至关重要，可以为检测大脑疾病、监测疾病进展和评估新疗法的有效性提供替代标记物。利用MRS，丰富的生化信息和准确的 代谢物的定量与光谱质量密切相关。在这方面，CMRR中的超高场MRI/MRS系统，特别是新的16.4T啮齿动物系统，9.4T动物系统和7T人体系统，以及未来的10.5T人体系统，提供了主要的优势。特别是，它们提供了卓越的信噪比(SNR)和光谱分辨率，从而提高了检测和量化大脑代谢物的重复性。此外，人类的脑部扫描 PET/CT、microPET/CT和神经SPECT现在可以在最近扩大的CMRR中使用。