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Physiology of Mind-Body Therapies: Meditative Breathing and Autonomic Adaptations

身心疗法的生理学：冥想呼吸和自主适应

基本信息

批准号：
8526387
负责人：
Suzanne Bertisch
金额：
$ 13.03万
依托单位：
BETH ISRAEL DEACONESS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-07-03 至 2015-07-02
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8526387
关键词：
Acute Autonomic nervous system Biometry Blood Pressure Breathing Cardiopulmonary Physiology Cardiovascular Diseases Cardiovascular Physiology Cardiovascular system Chronic low back pain Clinical Clinical Research Clinical Trials Cross-Sectional Studies Data Development Development Plans Disease Fellowship Foundations Future Goals Health Heart Human Hypertension Hypotension Individual Internist Intervention Knowledge Laboratories Lead Long-Term Effects Measurement Measures Mentors Methodology Mind-Body Intervention Mind-Body Method Nerve Obesity Pathway interactions Patients Pattern Physiological Physiological Processes Physiology Population Prevention strategy Public Health Randomized Controlled Trials Regulation Research Research Design Research Personnel Research Proposals Research Training Role Sinus Arrhythmia Sleeplessness Techniques Testing Therapeutic Time Training Variant base body-mind burden of illness cardiovascular risk factor career career development clinical application clinical effect cost evidence base experience improved interest novel patient oriented prevent research study respiratory response skills treatment strategy

项目摘要

Suzanne M. Bertisch, MD, MPH,is a general internist fellowship-trained in clinical research, who possesses a long-standing interest in mind-body therapies. Her long-term goal is to develop an independent research career studying the physiological effects of meditative techniques and developing targeted evidence-based mind-body therapies in populations with increased cardiovascular risk. Her immediate goal is to acquire knowledge and skills in autonomic cardiovascular physiology and mind-body clinical trial methodology. Dr. Bertisch's proposed career development plan includes: 1) acquiring laboratory measurement and data analytic skills in cardiopulmonary physiology; 2) gaining experience in the conduct of mind-body medicine clinical trials; 3) improving her knowledge of physiology, biostatistics, and study design through formal didactics; and 4) regular interaction with her mentors and expert collaborative team. This proposal includes two projects that focus on characterizing the acute and long-term effects of mind-body slow breathing (MBSB) upon autonomic activity. Despite efforts by several groups, much remains unknown about the acute effects of MBSB on sympathetic activity and the sustained adaptations in autonomic tone evoked by repetitive practice of MBSB. The candidate plans to: 1) compare the differential cardiovascular and autonomic effects of MBSB among long-term mind-body practitioners and non-practitioners in an acute cross-sectional study; 2) evaluate the feasibility of conducting a 12-week randomized controlled trial measuring the effects of MBSB upon autonomic activity and blood pressure in non-practitioners with obesity and high blood pressure; and obtain preliminary data for future more definitive studies. Both projects will be among the first to use modern measurement and analytic techniques, including a direct measure of sympathetic nerve activity. Completion of the proposed research and training plan will enhance Dr. Bertisch's ability to conduct patient-oriented mind-body research, further her understanding of autonomic cardiovascular physiology, and allow her to achieve her career goal of becoming an independent clinical researcher investigating the physiological mechanisms and clinical applications of mind-body therapies. RELEVANCE (Seeinstructions): Findings from this proposal will provide important information for future clinical and mechanistic studies of mind-body therapies, particularly in cardiovascular disease populations, such as hypertension. A better understanding of the clinical benefits and mechanisms of mind-body-breathing practices will assist the development of targeted mind-body based treatments for lowering blood pressure.

Suzanne M. Bertisch，医学博士，公共卫生硕士，是一名接受过临床研究培训的普通内科医生