Physiology of Mind-Body Therapies: Meditative Breathing and Autonomic Adaptations

身心疗法的生理学：冥想呼吸和自主适应

基本信息

批准号：
8526387
负责人：
Suzanne Bertisch
金额：
$ 13.03万
依托单位：
BETH ISRAEL DEACONESS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-07-03 至 2015-07-02
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8526387
关键词：
Acute Autonomic nervous system Biometry Blood Pressure Breathing Cardiopulmonary Physiology Cardiovascular Diseases Cardiovascular Physiology Cardiovascular system Chronic low back pain Clinical Clinical Research Clinical Trials Cross-Sectional Studies Data Development Development Plans Disease Fellowship Foundations Future Goals Health Heart Human Hypertension Hypotension Individual Internist Intervention Knowledge Laboratories Lead Long-Term Effects Measurement Measures Mentors Methodology Mind-Body Intervention Mind-Body Method Nerve Obesity Pathway interactions Patients Pattern Physiological Physiological Processes Physiology Population Prevention strategy Public Health Randomized Controlled Trials Regulation Research Research Design Research Personnel Research Proposals Research Training Role Sinus Arrhythmia Sleeplessness Techniques Testing Therapeutic Time Training Variant base body-mind burden of illness cardiovascular risk factor career career development clinical application clinical effect cost evidence base experience improved interest novel patient oriented prevent research study respiratory response skills treatment strategy

项目摘要

Suzanne M. Bertisch, MD, MPH,is a general internist fellowship-trained in clinical research, who possesses a long-standing interest in mind-body therapies. Her long-term goal is to develop an independent research career studying the physiological effects of meditative techniques and developing targeted evidence-based mind-body therapies in populations with increased cardiovascular risk. Her immediate goal is to acquire knowledge and skills in autonomic cardiovascular physiology and mind-body clinical trial methodology. Dr. Bertisch's proposed career development plan includes: 1) acquiring laboratory measurement and data analytic skills in cardiopulmonary physiology; 2) gaining experience in the conduct of mind-body medicine clinical trials; 3) improving her knowledge of physiology, biostatistics, and study design through formal didactics; and 4) regular interaction with her mentors and expert collaborative team. This proposal includes two projects that focus on characterizing the acute and long-term effects of mind-body slow breathing (MBSB) upon autonomic activity. Despite efforts by several groups, much remains unknown about the acute effects of MBSB on sympathetic activity and the sustained adaptations in autonomic tone evoked by repetitive practice of MBSB. The candidate plans to: 1) compare the differential cardiovascular and autonomic effects of MBSB among long-term mind-body practitioners and non-practitioners in an acute cross-sectional study; 2) evaluate the feasibility of conducting a 12-week randomized controlled trial measuring the effects of MBSB upon autonomic activity and blood pressure in non-practitioners with obesity and high blood pressure; and obtain preliminary data for future more definitive studies. Both projects will be among the first to use modern measurement and analytic techniques, including a direct measure of sympathetic nerve activity. Completion of the proposed research and training plan will enhance Dr. Bertisch's ability to conduct patient-oriented mind-body research, further her understanding of autonomic cardiovascular physiology, and allow her to achieve her career goal of becoming an independent clinical researcher investigating the physiological mechanisms and clinical applications of mind-body therapies. RELEVANCE (Seeinstructions): Findings from this proposal will provide important information for future clinical and mechanistic studies of mind-body therapies, particularly in cardiovascular disease populations, such as hypertension. A better understanding of the clinical benefits and mechanisms of mind-body-breathing practices will assist the development of targeted mind-body based treatments for lowering blood pressure.

MPH的Suzanne M. Bertisch，MD，是一项由临床研究中的一般国际奖学金培训，拥有对思维疗法的长期兴趣。她的长期目标是开发独立研究职业研究冥想技术的生理影响并发展有针对性的循证心血管风险增加的人群中的思维体疗法。她的直接目标是获得自主性心血管生理学和思维临床试验方法的知识和技能。博士贝尔蒂奇（Bertisch）提议的职业发展计划包括：1）获取实验室测量和数据心肺生理学的分析技能； 2）获得思维医学的经验临床试验； 3）通过正式提高她对生理学，生物统计学和研究设计的了解教学法; 4）与她的导师和专家协作团队定期互动。该建议包括两个项目的重点是表征思维体体缓慢呼吸的急性和长期影响（MBSB）自主活动。尽管有几个小组的努力，但对急性仍然不清楚 MBSB对交感神经活动的影响和自主语调的持续适应 MBSB的重复实践。候选人计划：1）比较差分心血管和 MBSB在急性中长期思维体从业者和非阶级的自主影响横断面研究； 2）评估进行为期12周的随机对照试验的可行性测量MBSB对肥胖症非授予者的自主活动和血压的影响和高血压；并获得初步数据以进行未来的更确定的研究。两个项目都将是最早使用现代测量和分析技术的人，包括直接衡量交感神经活动。拟议的研究和培训计划的完成将增强Bertisch博士的能够进行以患者为导向的心身研究，进一步了解自主教心血管生理学，并允许她实现成为独立临床的职业目标研究人员研究了思维疗法的生理机制和临床应用。相关性（参见Instructions）：该提案的发现将为未来的临床和机械研究提供重要信息思维体疗法，特别是在心血管疾病人群中，例如高血压。更好了解心身呼吸实践的临床益处和机制将有助于开发有针对性的基于思维的治疗方法，以降低血压。