Physiology of Mind-Body Therapies: Meditative Breathing and Autonomic Adaptations

身心疗法的生理学：冥想呼吸和自主适应

• 批准号: 7995242
• 负责人: Suzanne Bertisch
• 金额: $ 13.01万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-03 至 2014-07-02
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7995242
• 关键词: Acute; Autonomic nervous system; Biometry; Blood Pressure; Breathing; Cardiopulmonary Physiology; Cardiovascular Diseases; Cardiovascular Physiology; Cardiovascular system; Chronic low back pain; Clinical; Clinical Research; Clinical Trials; Cross-Sectional Studies; Data; Development; Development Plans; Disease; Fellowship; Foundations; Future; Goals; Health; Heart; Human; Hypertension; Hypotension; Individual; Internist; Intervention; Intervention Studies; Knowledge; Laboratories; Lead; Long-Term Effects; Measurement; Measures; Mentors; Methodology; Mind-Body Intervention; Mind-Body Method; Nerve; Obesity; Pathway interactions; Patients; Pattern; Physiological; Physiological Processes; Physiology; Population; Prevention; Public Health; Randomized Controlled Trials; Regulation; Research; Research Design; Research Personnel; Research Proposals; Research Training; Role; Sinus Arrhythmia; Sleeplessness; Techniques; Testing; Therapeutic; Time; Training; Variant; base; body-mind; burden of illness; cardiovascular risk factor; career; career development; clinical application; clinical effect; cost; evidence base; experience; improved; interest; novel; patient oriented; prevent; public health relevance; research study; respiratory; skills; treatment strategy

DESCRIPTION (provided by applicant): Suzanne M. Bertisch, MD, MPH, is a general internist fellowship-trained in clinical research, who possesses a long-standing interest in mind-body therapies. Her long-term goal is to develop an independent research career studying the physiological effects of meditative techniques and developing targeted evidence-based mind-body therapies in populations with increased cardiovascular risk. Her immediate goal is to acquire knowledge and skills in autonomic cardiovascular physiology and mind-body clinical trial methodology. Dr. Bertisch's proposed career development plan includes: 1) acquiring laboratory measurement and data analytic skills in cardiopulmonary physiology; 2) gaining experience in the conduct of mind-body medicine clinical trials; 3) improving her knowledge of physiology, biostatistics, and study design through formal didactics; and 4) regular interaction with her mentors and expert collaborative team. This proposal includes two projects that focus on characterizing the acute and long-term effects of mind-body slow breathing (MBSB) upon autonomic activity. Despite efforts by several groups, much remains unknown about the acute effects of MBSB on sympathetic activity and the sustained adaptations in autonomic tone evoked by repetitive practice of MBSB. The candidate plans to: 1) compare the differential cardiovascular and autonomic effects of MBSB among long-term mind-body practitioners and non-practitioners in an acute cross-sectional study; 2) evaluate the feasibility of conducting a 12-week randomized controlled trial measuring the effects of MBSB upon autonomic activity and blood pressure in non-practitioners with obesity and high blood pressure; and obtain preliminary data for future more definitive studies. Both projects will be among the first to use modern measurement and analytic techniques, including a direct measure of sympathetic nerve activity. Completion of the proposed research and training plan will enhance Dr. Bertisch's ability to conduct patient-oriented mind-body research, further her understanding of autonomic cardiovascular physiology, and allow her to achieve her career goal of becoming an independent clinical researcher investigating the physiological mechanisms and clinical applications of mind-body therapies. PUBLIC HEALTH RELEVANCE: Findings from this proposal will provide important information for future clinical and mechanistic studies of mind-body therapies, particularly in cardiovascular disease populations, such as hypertension. A better understanding of the clinical benefits and mechanisms of mind-body-breathing practices will assist the development of targeted mind-body based treatments for lowering blood pressure.

描述（由申请人提供）：苏珊娜·贝蒂奇（Suzanne M.她的长期目标是开发独立的研究职业，研究冥想技术的生理影响并在心血管风险增加的人群中开发有针对性的循证思维疗法。她的直接目标是获得自主性心血管生理学和思维临床试验方法的知识和技能。 Bertisch博士提出的职业发展计划包括：1）在心肺生理学中获得实验室测量和数据分析技能； 2）获得思维医学临床试验的经验； 3）通过正式的教学方法提高她对生理学，生物统计学和研究设计的知识； 4）与她的导师和专家协作团队定期互动。该提案包括两个项目，旨在表征思维慢呼吸缓慢（MBSB）对自主活动的急性和长期影响。尽管有几个小组的努力，但对于MBSB对同情活动的急性影响以及由MBSB重复实践引起的自主语调的持续适应性仍然不明。候选人计划：1）在一项急性横断面研究中，比较长期思维从业者和非阶级的MBSB的差异心血管和自主神经效应； 2）评估进行为期12周的随机对照试验的可行性，该试验测量了MBSB对肥胖症和高血压非授予者的自主性活动和血压的影响；并获得初步数据以进行未来的更确定的研究。这两个项目将是最早使用现代测量和分析技术的项目之一，包括直接衡量交感神经活动的衡量。拟议的研究和培训计划的完成将增强Bertisch博士进行以患者为导向的心身研究，进一步了解她对自主性心血管生理学的理解，并允许她实现自己的职业目标，即成为一名独立的临床研究人员，研究了研究生理学机制和心理治疗的临床应用。 公共卫生相关性：该提案的发现将为心身疗法的未来临床和机理研究提供重要信息，尤其是在心血管疾病人群中，例如高血压。更好地理解思想呼吸训练的临床益处和机制将有助于开发有针对性的基于思维的治疗方法，以降低血压。