Southeast Asia Malaria Research Center

东南亚疟疾研究中心

• 批准号: 8500136
• 负责人: LIWANG CUI
• 金额: $ 219.63万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8500136
• 关键词: Accounting; Address; Anti-malarial drug resistance; Antibodies; Area; Artemisinins; Biological Assay; Biology; Blood Circulation; Breeding; Cambodia; China; Chloroquine resistance; Collaborations; Communities; Country; Detection; Development; Diagnosis; Diagnostic; Disease; Drug Formulations; Drug resistance; Drug usage; Ecology; Ensure; Environmental Impact; Epidemiology; Face; Fostering; Genetic; Genomics; Goals; Health; Heterogeneity; Incidence; Institution; International; Knowledge; Laos; Life; Malaria; Measurement; Measures; Medical; Methods; Modeling; Molecular; Molecular Biology; Molecular Epidemiology; Monitor; Monoclonal Antibodies; Morbidity - disease rate; Multi-Drug Resistance; Myanmar; Parasite resistance; Parasites; Pattern; Pharmaceutical Preparations; Phase; Plasmodium falciparum; Plasmodium vivax; Population; Population Biology; Prevalence; Province; Public Health; Pyrimethamine-Sulfadoxine; Recording of previous events; Research; Research Personnel; Research Training; Resistance; Resources; Role; Scientist; Services; Site; Southeastern Asia; System; Thailand; Training Programs; Triad Acrylic Resin; Tribes; Vietnam; artemisinine; authority; base; burden of illness; chemotherapy; cost effective; data management; design; drug quality; epidemiology study; ethnic minority population; forest; genome-wide; improved; in vivo; innovation; meetings; mortality; neglect; programs; resistance mechanism; socioeconomics; tool; transmission process; vector; vector control

Malaria control in Southeast Asia faces a number of serious challenges that require coordinated and focused efforts. The uneven distribution of malaria incidences and limited resources call for the development of adaptable and cost-effective control strategies. Knowledge gaps in malaria epidemiology, vector biology and parasite genetics hinder the development of effective control measures. Emerging resistance of parasites to artemisinins and circulation of counterfeit/substandard artemisinin drugs that threaten regional and global malaria control campaigns demand close monitoring, and development of adequate countermeasures. To address these challenges, this ICEMR program brings together outstanding institutions in the U.S., Thailand, Myanmar and China, where internationally recognized investigators have a history of collaborations in malaria research and training. In strategically selected study sites of Myanmar, China, and Thailand that target the most impoverished areas in this region, this consortium will study urgent scientific questions important to this neglected region that are also pertinent to global malaria control. This program has three cores (administrative, data management, and molecular biology) and four scientific projects. Project 1 "Malaria epidemiology in Southeast Asia: Intra- and inter-country dynamics" will develop an accurate measurement of heterogeneity of the disease burden, and provide essential epidemiological information for developing and evaluating integrated malaria control strategies in multiple sites with varying epidemiological conditions. Project 2 "The malaria vectorial system and new vector control tools in Southeast Asia" aims to understand the ecology of malaria vectors in this region and develop innovative malaria transmission surveillance and control tools. Project 3 "Antimalarial drug resistance in P. falciparum" aims to elucidate the mechanism of artemisinin resistance using a high-throughput, genome-wide analytic tool and parasite populations from areas where artemisinin resistance is emerging. Project 4 "Development of monoclonal antibody-based assays for detection and quantification of artemisinin derivatives" will develop antibody based methods for quantification of artemisinins under field conditions for monitoring drug quality.

东南亚的疟疾控制面临着一些严重挑战，需要协调和集中努力。疟疾发病率分布不均，资源有限，因此需要制定适应性强、成本效益高的控制战略。疟疾流行病学、病媒生物学和寄生虫遗传学方面的知识差距阻碍了有效控制措施的制定。新出现的寄生虫对青蒿素的抗药性以及假冒/不合标准的青蒿素药物的流通威胁到区域和全球疟疾控制运动，需要密切监测，并制定适当的对策。为了应对这些挑战，ICEMR计划汇集了美国的优秀机构，在泰国、缅甸和中国，国际公认的研究人员在疟疾研究和培训方面有着合作的历史。在缅甸、中国和泰国战略性选定的研究地点，针对该地区最贫困的地区，该联盟将研究对这一被忽视地区至关重要的紧迫科学问题，这些问题也与全球疟疾控制有关。该计划有三个核心（行政，数据管理和分子生物学）和四个科学项目。项目1“东南亚的疟疾流行病学：国家内和国家间动态”将准确衡量疾病负担的异质性，并提供必要的流行病学信息，用于在流行病学条件不同的多个地点制定和评价疟疾综合控制战略。项目2“东南亚的疟疾病媒系统和新的病媒控制工具”旨在了解该区域的疟疾病媒生态，并开发创新的疟疾传播监测和控制工具。项目3“恶性疟原虫的抗疟抗药性”旨在利用高通量全基因组分析工具和正在出现青蒿素抗药性的地区的寄生虫种群，阐明青蒿素抗药性的机制。项目4“开发用于青蒿素衍生物检测和定量的单克隆抗体测定法”将开发用于在实地条件下定量青蒿素的抗体方法，以监测药物质量。